Zu "K16797" wurden 45 Artikel gefunden!
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GANT 58
Artikelnummer: TGM-T15370-100mg
Description: GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 µM). Target: Hedgehog/Smoothened. Smiles: c1cc(ccn1)-c1sc(c(c1-c1ccncc1)-c1ccncc1)-c1ccncc1. References: Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule...
| Schlagworte: | NSC 75503 |
| Anwendung: | GLI antagonist |
| CAS | 64048-12-0 |
| MW: | 392.48 D |
ab 42,00 €
Hedgehog Antagonist VIII
Artikelnummer: TGM-T35537-1mg
Description: Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain...
| Anwendung: | Cell-permeable Gli inhibitor |
| CAS | 330796-24-2 |
| MW: | 490.84 D |
ab 181,00 €
GLI1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02321-100ug
Description: Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal...
| Schlagworte: | Glioma-associated oncogene, Zinc finger protein GLI1, GLI1, Oncogene GLI |
| MW: | 23.3 kD |
ab 198,00 €
GLI1 Protein (Trx Tag) (recombinant human)
Artikelnummer: E-PDEH100517.100
Sequence: Asn470-Ser659. Fusion tag: N-Trx Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 38 kDa. Protein function: Protein function: Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340,...
| Schlagworte: | GLI, GLI1, Oncogene GLI, Zinc finger protein GLI1, Glioma-associated oncogene, Recombinant Human GLI1 Protein(Trx Tag) |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 304,00 €
Zinc finger protein GLI1 (GLI1), partial, human, recombinant
Artikelnummer: CSB-EP009499HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 921-1106aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP GFGPNLPNHK SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG PLKVGGTNPS CGHPEVGRLG GGPALYPPPE GQVCNPLDSL DLDNTQLDFV AILDEPQGLS...
| Schlagworte: | GLI, GLI1, Oncogene GLI, Zinc finger protein GLI1, Glioma-associated oncogene, Recombinant Human Zinc finger protein GLI1... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 23.3 kD |
ab 219,00 €
Zinc finger protein GLI1 (GLI1), partial, human, recombinant
Artikelnummer: CSB-EP009499HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 201-400aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal 6xHis-tagged. Target Protein Sequence: SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD GCSQEFDSQE QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP HKCTFEGCRK...
| Schlagworte: | GLI, GLI1, Oncogene GLI, Zinc finger protein GLI1, Glioma-associated oncogene, Recombinant Human Zinc finger protein GLI1... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 28.3 kD |
ab 219,00 €
Anti-GLI1
Artikelnummer: CSB-PA12989A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: GLI1. Antigen Species: Human
| Schlagworte: | Anti-GLI, Anti-GLI1, Anti-Oncogene GLI, Anti-Zinc finger protein GLI1, Anti-Glioma-associated oncogene, Gli 1 antibody,... |
| Anwendung: | ELISA, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-Gli1 (803-818)
Artikelnummer: 100-401-223
Protein function: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell...
| Schlagworte: | Anti-Gli, Anti-Gli1, Anti-Zinc finger protein GLI1, Anti-Glioma-associated oncogene homolog |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
719,00 €
Anti-Gli1
Artikelnummer: 100-401-223S
This whole rabbit antiserum was prepared by delipidation and defibrination followed by the addition of buffer salts and preservative. Reactivity is observed against Mouse and Human Gli-1. Cross-reactivity with other species is likely but has not been determined. No reaction occurs with human or mouse Gli-2 or Gli-3....
| Schlagworte: | Anti-Gli, Anti-Gli1, Anti-Zinc finger protein GLI1, Anti-Glioma-associated oncogene homolog |
| Anwendung: | ELISA, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse, human |
180,00 €
HPI-1 (hydrate)
Artikelnummer: Cay15221-10
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 > 30 µM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational...
| Schlagworte: | 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid-2-methoxyethyl... |
| Anwendung: | Hedgehog pathway inhibitor |
| MW: | 463.5 D |
ab 145,00 €
GANT 58
Artikelnummer: Cay14193-5
Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain...
| Schlagworte: | NSC 75503, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine |
| Anwendung: | GLI antagonist |
| CAS | 64048-12-0 |
| MW: | 392.5 D |
ab 99,00 €
Hedgehog Antagonist VIII
Artikelnummer: Cay16097-1
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers,...
| Schlagworte: | Hh Antagonist VIII,... |
| Anwendung: | Cell-permeable Gli inhibitor |
| CAS | 330796-24-2 |
| MW: | 490.8 D |
ab 100,00 €