Zu "K15729" wurden 44 Artikel gefunden!
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PF-4693627
Artikelnummer: TGM-T16504-10mg
Description: PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA). Target: Prostaglandin Receptor. Smiles:...
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1312815-93-2 |
| MW: | 502.43 D |
ab 91,00 €
PF-9184
Artikelnummer: TGM-T21738-1mg
Description: PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 16.5 nM, and it inhibits IL-1beta-induced PGE2 synthesis in vitro. Target: Prostaglandin Receptor. Smiles: OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1. References: Gabriel...
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1221971-47-6 |
| MW: | 461.32 D |
ab 31,00 €
mPGES-1 Inhibitor-1
Artikelnummer: TGM-T28089-10mg
Description: mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury. Target: Prostaglandin Receptor. Smiles: O=C(NC1=NC=CN1)C2=CC(=CC=C2Cl)CNC(=O)C(C)(C)C. References: Norman BH,et al....
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1381846-21-4 |
| MW: | 334.8 D |
ab 191,00 €
2,5-dimethyl Celecoxib
Artikelnummer: TGM-T35610-100mg
Description: 2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators. Target: Prostaglandin Receptor, Apoptosis, Wnt/beta-catenin. Smiles:...
| Anwendung: | mPGES-1 inhibitor |
| CAS | 457639-26-8 |
| MW: | 395.4 D |
ab 53,00 €
CAY10678
Artikelnummer: TGM-T38369-100mg
Description: CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS. Target: PD-1/PD-L1, Prostaglandin Receptor. Smiles: O=C(NC1CCCC1)C2CCN(C3=NC=4C=C(C(=CC4N3C(C)C)C)C)CC2. References: Fukuda Y,et al. Inhibition of...
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1268709-57-4 |
| MW: | 382.54 D |
ab 48,00 €
Vipoglanstat
Artikelnummer: TGM-T70874-100mg
Description: Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury. Target: Others. Smiles:...
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1360622-01-0 |
| MW: | 678.52 D |
ab 1.933,00 €
Prostaglandin E synthase (Ptges), mouse, recombinant
Artikelnummer: CSB-CF018976MO.100
Organism: Mus musculus (Mouse). Source: in vitro E.coli expression system. Expression Region: 1-153aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-SUMO-tagged. Target Protein Sequence: MPSPGLVMES GQVLPAFLLC STLLVIKMYA VAVITGQMRL RKKAFANPED ALKRGGLQYY RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA...
| Schlagworte: | Pges, Ptges, mPGES-1, Prostaglandin E synthase, Glutathione peroxidase PTGES, Glutathione transferase PTGES, Microsomal... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | mouse |
| MW: | 35.8 kD |
ab 1.413,00 €
Anti-PTGES
Artikelnummer: CSB-PA003751.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-PTGES, Anti-MPGES-1, Anti-MGST1-L1, Anti-Prostaglandin E synthase, Anti-p53-induced gene 12 protein, Anti-Glutathione... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-Prostaglandin E Synthase-1 (microsomal)
Artikelnummer: Cay160140-1
Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 (Cay-17020) to PGE2 (Cay-14010). PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal...
| Schlagworte: | Anti-PTGES, Anti-Prostaglandin E synthase, Anti-Prostaglandin E synthase, Anti-Glutathione peroxidase PTGES,... |
| Anwendung: | IF, WB |
| Wirt: | Rabbit |
422,00 €
Vipoglanstat
Artikelnummer: Cay37925-1
Vipoglanstat is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1, IC50 = =0.5 nM in isolated human whole blood). It reduces LPS-induced increases in the influx of neutrophils and levels of cytokines in bronchoalveolar lavage fluid (BALF), as well as the expression of PTGES, the gene encoding mPGES-1,...
| Schlagworte: | BI 1029539, GS-248, OX-MPI,... |
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1360622-01-0 |
| MW: | 678.5 D |
ab 267,00 €
CAY10678
Artikelnummer: Cay15129-1
Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2. Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. CAY10678 is a benzoimidazole that potently inhibits human and rat...
| Schlagworte: | mPGES-1 Inhibitor III, N-cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide |
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1268709-57-4 |
| MW: | 382.5 D |
ab 84,00 €
MF63
Artikelnummer: Cay13217-1
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig...
| Schlagworte: | 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile |
| Anwendung: | mPGES-1 inhibitor |
| CAS | 892549-43-8 |
| MW: | 378.8 D |
ab 46,00 €