Zu "K15528" wurden 73 Artikel gefunden!
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CAY10401
Artikelnummer: Cay71652-1
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. CAY10401 is approximately 580 fold more potent than oleyl trifluoromethyl ketone...
| Schlagworte: | 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one |
| Anwendung: | FAAH inhibitor |
| CAS | 288862-89-5 |
| MW: | 382.5 D |
ab 66,00 €
PHOP
Artikelnummer: Cay71655-100
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PHOP is a potent FAAH inhibitor, exhibiting Ki values of 0.094 nM and 0.2 nM for the human and rat enzymes, respectively. Using a proteomics approach, PHOP was screened...
| Schlagworte: | CAY10402, Phenyl hexanoyl oxazolopyridine, 1-oxazolo[4,5-b]pyridin-2-yl-6-phenyl-1-hexanone |
| Anwendung: | FAAH inhibitor |
| CAS | 288862-83-9 |
| MW: | 294.4 D |
ab 66,00 €
FAAH inhibitor 1
Artikelnummer: TGM-T11256-100mg
Description: FAAH inhibitor 1 (Benzothiazole analog 3) is a potent FAAH inhibitor with an IC50 of 18 nM. Target: FAAH. Smiles: Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)C2CCN(CC2)S(=O)(=O)c2cccs2)cc1. References: Wang Xueqing, et al. Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty...
| Schlagworte: | Benzothiazole analog 3 |
| Anwendung: | FAAH inhibitor |
| CAS | 326866-17-5 |
| MW: | 497.65 D |
ab 78,00 €
SA57
Artikelnummer: TGM-T12826-10mg
Description: SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH). Target: FAAH. Smiles: C(OCC(NC)=O)(=O)N1CCC(CCC2=CC=C(Cl)C=C2)CC1. References: Niphakis MJ, et al. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase...
| Anwendung: | FAAH inhibitor |
| CAS | 1346169-63-8 |
| MW: | 338.83 D |
ab 77,00 €
LY2183240
Artikelnummer: TGM-T15802-100mg
Description: LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM). Target: Autophagy, FAAH. Smiles: CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1. References: Dickason-Chesterfield AK, et al. Pharmacological...
| Anwendung: | Potent, competitive anandamide uptake inhibitor |
| CAS | 874902-19-9 |
| MW: | 307.35 D |
ab 39,00 €
PF 750
Artikelnummer: TGM-T16515-100mg
Description: PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times. Target: FAAH. Smiles: O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1. References: Ahn K, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors...
| Schlagworte: | PF-750, UNII-7756CPP14K, ZINC27647189 |
| Anwendung: | FAAH inhibitor |
| CAS | 959151-50-9 |
| MW: | 345.44 D |
ab 33,00 €
JNJ-42165279
Artikelnummer: TGM-T3215-100mg
Description: JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 µM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not...
| Schlagworte: | JNJ42165279 |
| Anwendung: | Irreversable FAAH inhibitor |
| CAS | 1346528-50-4 |
| MW: | 410.8 D |
ab 45,00 €
PDP-EA
Artikelnummer: TGM-T28353-100mg
Description: PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH. Target: FAAH. Smiles: CCCCCCCCCC CCCCCc1cccc(OCC(=O)NCCO)c1. References: Cojutti P, Giangreco M, Isola M, Pea F. Limited sampling strategies for determining the area under the plasma...
| Anwendung: | FAAH enhancer |
| CAS | 861891-72-7 |
| MW: | 405.61 D |
ab 35,00 €
BIA 10-2474
Artikelnummer: TGM-T3354-100mg
Description: BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474(BIA10-2474) interacts...
| Schlagworte: | BIA10-2474 |
| Anwendung: | FAAH inhibitor |
| CAS | 1233855-46-3 |
| MW: | 300.36 D |
ab 31,00 €
N-Benzylpalmitamide
Artikelnummer: TGM-T3S2105-100mg
Description: N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders. Target: Others, Autophagy, FAAH. Smiles: CCCCCCCCCC CCCCCC(=O)NCc1ccccc1....
| Schlagworte: | N-Benzylhexadecanamide, Macamide 1 |
| Anwendung: | Long-chain fatty acid amide, moderate FAAH inhibitor |
| CAS | 74058-71-2 |
| MW: | 345.56 D |
ab 31,00 €
PF-04457845
Artikelnummer: TGM-T4323-100mg
Description: PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM). Target: FAAH, Autophagy. Smiles: FC(F)(F)c1ccc(Oc2cccc(C=C3CCN(CC3)C(=O)Nc3cccnn3)c2)nc1. References: Johnson DS, et al. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and...
| Schlagworte: | PF 04457845, PF04457845 |
| Anwendung: | Irreversible FAAH inhibitor |
| CAS | 1020315-31-4 |
| MW: | 455.43 D |
ab 31,00 €
PF-3845
Artikelnummer: TGM-T6043-100mg
Description: PF-3845 is a potent, selective, and irreversible FAAH inhibitor with a Ki of 230 nM, exhibiting negligible activity against FAAH2. Target: FAAH, Autophagy. Smiles: FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc3cccnc3)c2)nc1. References: Ahn K et al, Chem Biol, 2009,16(4), 411-20.
| Anwendung: | FAAH inhibitor |
| CAS | 1196109-52-0 |
| MW: | 456.46 D |
ab 35,00 €