Zu "K14970" wurden 50 Artikel gefunden!
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Anti-Menin
Artikelnummer: A300-105A
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 178,00 €
Menin-MLL inhibitor MI-2
Artikelnummer: TGM-T2649-100mg
Description: Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. Target: Epigenetic Reader Domain, Histone Methyltransferase, Apoptosis. Smiles: CCCc1cc2c(ncnc2s1)N1CCN(CC1)C1=NCC(C)(C)S1. References: Grembecka J, et al. Nat Chem Biol. 2012, 8(3), 277-284.
| Schlagworte: | MI 2, MI-2, Menin-MLL inhibitor 2, Menin-MLL Inhibitor, MI2 |
| Anwendung: | Menin-MLL inhibitor |
| CAS | 1271738-62-5 |
| MW: | 375.55 D |
ab 37,00 €
Menin-MLL inhibitor 4
Artikelnummer: TGM-T12002-100mg
Description: Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction . Target: Others. Smiles: C(N1CC2(CN(CC2)C=3C(OC4=C(C(N(C(C)C)C(C)C)=O)C=C(F)C=C4)=CN=CN3)CC1)C=5C=C6C(=CC5)NC(=O)N6. References: Salvacion Cacatian, et al....
| Anwendung: | Menin-MLL inhibitor |
| CAS | 2169916-13-4 |
| MW: | 587.69 D |
ab 2.573,00 €
SNDX-5613
Artikelnummer: TGM-T12943-100mg
Description: SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles:...
| Anwendung: | Targets menin (MEN1, MNN1) |
| CAS | 2169919-21-3 |
| MW: | 630.82 D |
ab 67,00 €
VTP50469
Artikelnummer: TGM-T13336-100mg
Description: VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity. Target: Epigenetic Reader Domain, Histone Methyltransferase, Apoptosis. Smiles:...
| Anwendung: | Menin-MLL1 fusion protein interaction inhibitor |
| CAS | 2169916-18-9 |
| MW: | 630.82 D |
ab 175,00 €
MI-2-2
Artikelnummer: TGM-T28036-1mg
Description: MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. Target: Histone Methyltransferase. Smiles: C(C(F)(F)F)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C=4SC(C)(C)CN4. References: Shi A, et al. Structural insights into...
| Schlagworte: | MI22, MI 2 2 |
| Anwendung: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 1454920-20-7 |
| MW: | 415.5 D |
ab 58,00 €
MI-3
Artikelnummer: TGM-T2643-1mg
Description: MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM). Target: Apoptosis, Histone Methyltransferase, Epigenetic Reader Domain. Smiles: CC(C)c1cc2c(ncnc2s1)N1CCN(CC1)C1=NCC(C)(C)S1. References: Grembecka J, et al. Nat Chem Biol. 2012, 8(3),...
| Schlagworte: | Menin-MLL Inhibitor, Menin-MLL inhibitor 3, MI 3 |
| Anwendung: | MLL / menin interaction inhibitor |
| CAS | 1271738-59-0 |
| MW: | 375.55 D |
ab 46,00 €
Ziftomenib
Artikelnummer: TGM-T39585-100mg
Description: Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research. Target: Histone Methyltransferase. Smiles: CNc1nc(NC2CCN(Cc3ccc4n(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1. References: Rausch J, et al. Menin inhibitor...
| Schlagworte: | KO-539 |
| Anwendung: | Targets menin (MEN1, MNN1) |
| CAS | 2134675-36-6 |
| MW: | 717.871 D |
ab 114,00 €
Menin-MLL inhibitor 26
Artikelnummer: TGM-T72360-100mg
Description: Menin-MLL inhibitor 26 is a Menin-MLL inhibitor. Menin-MLL inhibitor 26 also is an active reference. Menin-MLL inhibitor 26 can inhibits cell growth. Menin-MLL inhibitor 26 can be used for the research of leukemia . Target: Others. Smiles:...
| Anwendung: | Menin-MLL inhibitor |
| CAS | 2440018-29-9 |
| MW: | 574.62 D |
ab 3.323,00 €
M-89 MLL inhibitor
Artikelnummer: TGM-T69629-100mg
Description: M-89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction (Kd = 1.4 nM, IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4,11...
| Anwendung: | Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction inhibitor |
| CAS | 2446155-01-5 |
| MW: | 657.87 D |
ab 3.924,00 €
Menin-MLL inhibitor 20
Artikelnummer: TGM-T9399-100mg
Description: Menin-MLL inhibitor 20 is an irreversible inhibitor of the menin-MLL interaction, exhibiting antitumor activities. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CC(C)(C)OC(=O)N[C@@H]1CCCN(Cc2ccnc(c2)C(=O)Nc2ccc(cc2)-c2cc3c(ncnc3[nH]2)N2CCOCC2)C1. References: Thomas Butler, et al....
| Anwendung: | Irreversible menin-MLL interaction inhibitor |
| CAS | 2448173-47-3 |
| MW: | 612.72 D |
ab 34,00 €
MI-463
Artikelnummer: TGM-TQ0058-100mg
Description: MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). Target: Histone Methyltransferase, Epigenetic Reader Domain. Smiles: Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2[nH]c(cc12)C#N. References: Borkin D, et al. Pharmacologic inhibition of the Menin-MLL...
| Anwendung: | Menin-MLL fusion protein interaction inhibitor |
| CAS | 1628317-18-9 |
| MW: | 484.54 D |
ab 31,00 €