Zu "K14461" wurden 16 Artikel gefunden!
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Ezetimibe
Artikelnummer: TGM-T1593-100mg
Description: Ezetimibe (SCH 58235) is a dietary cholesterol absorption inhibitor that exerts its physiologic effect by decreasing cholesterol absorption. Target: NPC1L1, Autophagy, Nrf2, Others. Smiles: C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4. References: Clader JW, et al. J...
| Schlagworte: | SCH 58235 |
| Anwendung: | Targets Niemann-Pick C1-like protein 1 (NPC1L1) |
| CAS | 163222-33-1 |
| MW: | 409.43 D |
ab 42,00 €
Human NPC1L1 Protein, His Tag
Artikelnummer: DIM-PME100720.10
Recombinant human NPC1L1 protein with C-terminal 6×His tag. NPC1L1(Glu22-Ser284) 6×His tag, Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that...
| Schlagworte: | NPC1-like intracellular cholesterol transporter 1, Niemann-Pick C1-like protein 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 28.8 kD |
ab 112,00 €
NPC1L1 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100089.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1, LDLCQ7, NPC11L1, SLC65A2, Human... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 148.7 kD |
ab 1.291,00 €
Ezetimibe
Artikelnummer: Cay16331-25
Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the...
| Schlagworte: | Ezetrol, SCH 58235, (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Anwendung: | NPC1L1 inhibitor, intestinal cholesterol absorption inhibitor |
| CAS | 163222-33-1 |
| MW: | 409.4 D |
ab 100,00 €
NPC1-like intracellular cholesterol transporter 1...
Artikelnummer: CSB-EP890689HUl1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 22-284aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal HA-tagged. Target Protein Sequence: EPYTTIHQPG YCAFYDECGK NPELSGSLMT LSNVSCLSNT PARKITGDHL ILLQKICPRL YTGPNTQACC SAKQLVSLEA SLSITKALLT RCPACSDNFV NLHCHNTCSP...
| Schlagworte: | Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1, Recombinant Human NPC1-like... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 33.1 kD |
ab 364,00 €
Ezetimibe-d4
Artikelnummer: Cay25044-1
Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Cay-16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of...
| Schlagworte: | Ezetrol-d4,... |
| Anwendung: | Internal standard, GC-MS, LC-MS |
| CAS | 1093659-89-2 |
| MW: | 413.5 D |
657,00 €
Ezetimibe
Artikelnummer: BPS-27749-2
Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.
| Schlagworte: | ezetimibe, Zetia, (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one, |
| Anwendung: | Cholesterol absorption inhibitor, NPC1L1 inhibitor |
| MW: | 409.4 D |
ab 367,00 €
3'-(2-Fluorophenyl) Ezetimibe
Artikelnummer: Cay34855-1
3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor ezetimibe (Cay-16331).Formal Name: (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. CAS Number: 1798008-25-9. Molecular Formula: C24H21F2NO3. Formula Weight: 409.4. Purity:...
| Schlagworte: | (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Anwendung: | Ezetimibe isomer |
| CAS | 1798008-25-9 |
| MW: | 409.4 D |
ab 150,00 €
NPC1L1 (Vector pUC, Accession No. BC117178)
Artikelnummer: CSB-CL890689HU.10
Length: 3999 Sequence: atggcggagg ccggcctgag gggctggctg ctgtgggccc tgctcctgcg cttggcccag agtgagcctt acacaaccat ccaccagcct ggctactgcg ccttctatga cgaatgtggg aagaacccag agctgtctgg aagcctcatg acactctcca acgtgtcctg cctgtccaac acgccggccc gcaagatcac aggtgatcac ctgatcctat tacagaagat ctgcccccgc ctctacaccg gccccaacac...
| Schlagworte: | Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1 |
| Anwendung: | Molecular biology, clone |
| Spezies-Reaktivität: | human |
1.658,00 €
Human NPC1L1 Full-Length Bioactive Membrane Protein
Artikelnummer: G-HDFP070.10
Protein function: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct...
| Schlagworte: | NPC1L1, Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
1.486,00 €
NPC1L1, Human NPC1 (Niemann-Pick disease, type C1,...
Artikelnummer: VHPS-6284
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | NPC1L1, Niemann-Pick C1-like protein 1 |
| Anwendung: | RNA quantification |
44,00 €
Npc1L1, Mouse NPC1-like 1, Real Time PCR Primer Set
Artikelnummer: VMPS-4302
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Npc1l1, Niemann-Pick C1-like protein 1 |
| Anwendung: | RNA quantification |
44,00 €