Zu "K14426" wurden 32 Artikel gefunden!
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Hydrochlorothiazide
Artikelnummer: TGM-T1449-50mg
Description: Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. Target: TGF-beta/Smad, Carbonic Anhydrase, Potassium Channel. Smiles: NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1. References: Ran XW, et al. Sichuan Da Xue Xue Bao Yi Xue...
| Schlagworte: | HCTZ |
| Anwendung: | Targets solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3, TSC) |
| CAS | 58-93-5 |
| MW: | 297.74 D |
30,00 €
Hydrochlorothiazide Impurity C
Artikelnummer: TGM-T35728-1mg
Description: Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4]. Target: Others....
| Anwendung: | Impurity |
| CAS | 402824-96-8 |
| MW: | 607.49 D |
ab 306,00 €
Hydrochlorothiazid-d2
Artikelnummer: TGM-TMID-0238-1mg
Description: Hydrochlorothiazid-d2 is a deuterated compound of Hydrochlorothiazid. Hydrochlorothiazid has a CAS number of 58-93-5. Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. Smiles: O=S1(=O)C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NC(N1)([2H])[2H]
| Anwendung: | GC-MS, LC-MS internal standard, quantification, thiazide diuretic |
| CAS | 1219798-89-6 |
| MW: | 299.75 D |
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Hydrochlorothiazide-3,3-d2
Artikelnummer: Cay39983-1
Hydrochlorothiazide-3,3-d2 is intended for use as an internal standard for the quantification of hydrochlorothiazide (Cay-21304) by GC- or LC-MS. Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.Formal Name:...
| Schlagworte: | HCTZ-3,3-d2, HCTZ-d2, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-d2, 1,1-dioxide |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, thiazide diuretic |
| CAS | 1219798-89-6 |
| MW: | 299.8 D |
ab 133,00 €
Human NCCT (Na-Cl Cotransporter) ELISA Kit
Artikelnummer: ELK-ELK3971.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NCCT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NCCT. Next,...
| Schlagworte: | NCC, Na-Cl symporter, Na-Cl cotransporter, Solute carrier family 12 member 3, Thiazide-sensitive sodium-chloride... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Metolazone
Artikelnummer: Cay15987-10
Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in...
| Schlagworte: | SR 720-22, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide |
| Anwendung: | Na+-Cl- symport / SLC12A3 inhibitor |
| CAS | 17560-51-9 |
| MW: | 365.8 D |
ab 43,00 €
Chlorthalidone
Artikelnummer: Cay16213-10
Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII,...
| Schlagworte: | Hygroton, NSC 69200, Oradil, Thalitone(R), 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide |
| Anwendung: | SLC12A3 / Sodium/chloride cotransporter inhibitor |
| CAS | 77-36-1 |
| MW: | 338.8 D |
ab 66,00 €
Trichlormethiazide
Artikelnummer: Cay29331-5
Trichlormethiazide is a thiazide diuretic. It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine...
| Schlagworte: | 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide |
| Anwendung: | Antihypertensive, Diuretic, Na+-Cl- symport inhibitor |
| CAS | 133-67-5 |
| MW: | 380.7 D |
ab 43,00 €
-30 %
Rabattaktion
Anti-SLC12A3 / NCC
Artikelnummer: ARG22199.50
Protein function: Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:8021284). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2, either...
| Schlagworte: | Anti-Tsc, Anti-Slc12a3, Anti-Na-Cl symporter, Anti-Solute carrier family 12 member 3, Anti-Thiazide-sensitive... |
| Anwendung: | WB, IHC, ICC, IF, EM |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | dog, human, mouse, rat |
520,00 €
364,00 €
Hydrochlorothiazide
Artikelnummer: LKT-H9614.100
A thiazide diuretic commonly used as an antihypertensive. A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and...
| Anwendung: | Na+-Cl- symport inhibitor |
| CAS | 58-93-5 |
| MW: | 297.74 D |
ab 72,00 €
Hydrochlorothiazide
Artikelnummer: Cay21304-1
Hydrochlorothiazide (HCTZ) is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.Formal Name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 58-93-5. Synonyms: HCTZ, NSC 53477, SU 5879....
| Schlagworte: | HCTZ, NSC 53477, SU 5879, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide |
| Anwendung: | Diuretic, Na+-Cl- symport inhibitor |
| CAS | 58-93-5 |
| MW: | 297.7 D |
ab 43,00 €
Hydrochlorothiazide Impurity C
Artikelnummer: Cay22384-1
Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. Hydrochlorothiazide (Cay-21304) is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.Formal Name:...
| Schlagworte: | N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4... |
| Anwendung: | Impurity |
| CAS | 402824-96-8 |
| MW: | 607.5 D |
ab 168,00 €