Zu "K14382" wurden 60 Artikel gefunden!
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Sodium/glucose cotransporter 2 (SLC5A2)-VLPs, recombinant...
Artikelnummer: CSB-MP021679HU.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 1-672aa. Protein Length: Full Length. Tag Info: C-terminal Flag-tagged. Target Protein Sequence: MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA GVITMPQYLR...
| Schlagworte: | SLC5A2, Na(+)/glucose cotransporter 2, Sodium/glucose cotransporter 2, Solute carrier family 5 member 2, Low affinity... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Mammalian cells |
| Ursprungsart: | human |
| MW: | 73.9 kD |
ab 579,00 €
Empagliflozin
Artikelnummer: AG-CR1-3619-M010
White solid. Soluble in DMSO. Slightly soluble in water or ethanol. Antidiabetic agent, Potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor. >,300-fold selectivity over SGLT-1, 4, 5 and 6, SGLT-2 is found almost exclusively in the proximal tubules of nephronic components in kidneys. Inhibition...
| Schlagworte: | Jardiance, BI-10773 |
| Anwendung: | Antidiabetic agent, SGLT2 inhibitor |
| CAS | 864070-44-0 |
| MW: | 450,9 D |
ab 77,00 €
Sergliflozin A
Artikelnummer: Cay14342-1
Sergliflozin A is an inhibitor of sodium-glucose cotransporter 2 (SGLT2, Ki = 2.39 nM for the human transporter) and an active metabolite of sergliflozin etabonate. It is formed from sergliflozin etabonate by esterases and selectively inhibits SGLT2 over SGLT1 (Ki = 708 nM for the human transporter). Co-infusion of...
| Schlagworte: | 2[(4methoxyphenyl)methyl]phenyl, beta-D-glucopyranoside |
| Anwendung: | SGLT2 (SLC5A2, sodium/glucose cotransporter) inhibitor, active sergliflozin etabonate metabolite |
| CAS | 360775-96-8 |
| MW: | 376.4 D |
ab 67,00 €
Empagliflozin
Artikelnummer: TGM-T1766-5mg
Description: Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. Target: SGLT. Smiles:...
| Schlagworte: | BI 10773 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 864070-44-0 |
| MW: | 450.91 D |
ab 40,00 €
Remogliflozin
Artikelnummer: TGM-T24708-10mg
Description: Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). Target: Others. Smiles: C(C=1C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN(C(C)C)C1C)C3=CC=C(OC(C)C)C=C3. References: Sadurní A, Kehr G, Ahlqvist M, Wernevik J, Sjögren...
| Schlagworte: | GSK189074, Remogliflozin A, GSK-189074, GSK 189074 |
| Anwendung: | Antidiabetic, SGLT-2 inhibitor |
| CAS | 329045-45-6 |
| MW: | 450.53 D |
ab 117,00 €
Sergliflozin etabonate
Artikelnummer: TGM-T28757-100mg
Description: Sergliflozin etabonate (KGT-1251) is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity. Target: SGLT. Smiles: O(C1=C(CC2=CC=C(OC)C=C2)C=CC=C1)[C@@H]3O[C@H](COC(OCC)=O)[C@@H](O)[C@H](O)[C@H]3O. References: Hussey EK, et al. Multiple-dose pharmacokinetics and...
| Schlagworte: | GW-869682, GW-869682X, KGT-1251, GW869682X, GW869682, KGT1251 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 408504-26-7 |
| MW: | 448.46 D |
ab 194,00 €
Dapagliflozin-3-O-beta-D-Glucuronide
Artikelnummer: TGM-T35619-1mg
Description: Dapagliflozin-3-O-beta-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to...
| Anwendung: | SGLT2 inhibitor |
| CAS | 1351438-75-9 |
| MW: | 585 D |
ab 352,00 €
Ertugliflozin
Artikelnummer: TGM-T4999-100mg
Description: PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). Target: SGLT. Smiles: CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1. References: Mascitti V, et al. Discovery of a clinical candidate from the...
| Schlagworte: | PF-04971729, MK-8835 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 1210344-57-2 |
| MW: | 436.88 D |
ab 45,00 €
Tofogliflozin (hydrate)
Artikelnummer: TGM-T5016-100mg
Description: Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2, with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2, respectively. Target: ROS, Reactive Oxygen Species, SGLT. Smiles:...
| Schlagworte: | Tofogliflozin hydrate, CSG-452 hydrate |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 1201913-82-7 |
| MW: | 404.45 D |
ab 40,00 €
5-Methylcytidine
Artikelnummer: TGM-T5912-100mg
Description: 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms. Target: Endogenous Metabolite. Smiles: Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)nc1N. References: Transcriptome-wide mapping of 5-methylcytidine RNA...
| Anwendung: | DNA methylation studies |
| CAS | 2140-61-6 |
| MW: | 257.24 D |
ab 48,00 €
Bexagliflozin
Artikelnummer: TGM-T7217-100mg
Description: Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 2 nM for human SGLT2 and 5.6 µM for human SGLT1. Target: SGLT. Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCOC3CC3)cc2)c1. References: Zhang W , Welihinda A ,...
| Schlagworte: | EGT0001442, THR-1442, EGT1442 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 1118567-05-7 |
| MW: | 464.94 D |
ab 65,00 €
T-1095
Artikelnummer: TGM-T9590-100mg
Description: T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). Target: transporter, SGLT. Smiles: COC(=O)OC[C@H]1O[C@@H](Oc2cc(C)cc(O)c2C(=O)CCc2ccc3occc3c2)[C@H](O)[C@@H](O)[C@@H]1O. References: Adachi T, et...
| Anwendung: | SGLT1 / SGLT2 inhibitor |
| CAS | 209746-59-8 |
| MW: | 516.49 D |
ab 48,00 €