Zu "K14382" wurden 59 Artikel gefunden!
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Sergliflozin A
Artikelnummer: Cay14342-1
Sergliflozin A is an inhibitor of sodium-glucose cotransporter 2 (SGLT2, Ki = 2.39 nM for the human transporter) and an active metabolite of sergliflozin etabonate. It is formed from sergliflozin etabonate by esterases and selectively inhibits SGLT2 over SGLT1 (Ki = 708 nM for the human transporter). Co-infusion of...
| Schlagworte: | 2[(4methoxyphenyl)methyl]phenyl, beta-D-glucopyranoside |
| Anwendung: | SGLT2 (SLC5A2, sodium/glucose cotransporter) inhibitor, active sergliflozin etabonate metabolite |
| CAS | 360775-96-8 |
| MW: | 376.4 D |
ab 67,00 €
Empagliflozin
Artikelnummer: TGM-T1766-5mg
Description: Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. Target: SGLT. Smiles:...
| Schlagworte: | BI 10773 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 864070-44-0 |
| MW: | 450.91 D |
ab 41,00 €
Canagliflozin
Artikelnummer: TGM-T1782-100mg
Description: Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM). Target: SGLT. Smiles:...
| Schlagworte: | JNJ 24831754ZAE, JNJ 28431754AAA, TA 7284, JNJ 28431754 |
| Anwendung: | SGLT2 inhibitor |
| CAS | 842133-18-0 |
| MW: | 444.52 D |
ab 45,00 €
Canagliflozin hemihydrate
Artikelnummer: TGM-T1782L-1mL
Description: Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter...
| Schlagworte: | JNJ-28431754, TA-7284, JNJ 28431754, TA7284, TA 7284, JNJ28431754 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 928672-86-0 |
| MW: | 907.05 D |
ab 45,00 €
O-Desethyl Dapagliflozin
Artikelnummer: TGM-T67849-100mg
Description: O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM. Target: SGLT. Smiles: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(O)C=C3)=C(Cl)C=C2. References: Lansdell, Mark I., Bioorganic & Medicinal Chemistry Letters (2008), 18(18), 4944-4947, CAplus and MEDLINE.
| Schlagworte: | Empagliflozin-4 |
| Anwendung: | SGLT2 inhibitor |
| CAS | 864070-37-1 |
| MW: | 380.82 D |
ab 54,00 €
SGLT inhibitor-1
Artikelnummer: TGM-T12893-100mg
Description: SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). Target: SGLT. Smiles: O(C)C=1C(=CC(CC=2C=C3C(=CC2)OCCO3)=C4C1CCO4)[C@@H]5O[C@H](CO)[C@@H](F)[C@H](O)[C@H]5O. References: Xu G, et al. Design, synthesis...
| Anwendung: | SGLT inhibitor |
| CAS | 2247314-23-2 |
| MW: | 462.46 D |
ab 2.572,00 €
Ertugliflozin L-pyroglutamic acid
Artikelnummer: TGM-T15244-100mg
Description: Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM, suitable for studies on the treatment of type 2 diabetes mellitus. Target: Others, SGLT. Smiles:...
| Schlagworte: | PF-04971729 L-pyroglutamic acid |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 1210344-83-4 |
| MW: | 566 D |
ab 41,00 €
Remogliflozin
Artikelnummer: TGM-T24708-10mg
Description: Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). Target: Others. Smiles: C(C=1C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN(C(C)C)C1C)C3=CC=C(OC(C)C)C=C3. References: Sadurní A, Kehr G, Ahlqvist M, Wernevik J, Sjögren...
| Schlagworte: | GSK189074, Remogliflozin A, GSK-189074, GSK 189074 |
| Anwendung: | Antidiabetic, SGLT-2 inhibitor |
| CAS | 329045-45-6 |
| MW: | 450.53 D |
ab 119,00 €
Sergliflozin etabonate
Artikelnummer: TGM-T28757-100mg
Description: Sergliflozin etabonate (KGT-1251) is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity. Target: SGLT. Smiles: O(C1=C(CC2=CC=C(OC)C=C2)C=CC=C1)[C@@H]3O[C@H](COC(OCC)=O)[C@@H](O)[C@H](O)[C@H]3O. References: Hussey EK, et al. Multiple-dose pharmacokinetics and...
| Schlagworte: | GW-869682, GW-869682X, KGT-1251, GW869682X, GW869682, KGT1251 |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 408504-26-7 |
| MW: | 448.46 D |
ab 198,00 €
Dapagliflozin-3-O-beta-D-Glucuronide
Artikelnummer: TGM-T35619-1mg
Description: Dapagliflozin-3-O-beta-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to...
| Anwendung: | SGLT2 inhibitor |
| CAS | 1351438-75-9 |
| MW: | 585 D |
ab 359,00 €
Remogliflozin etabonate
Artikelnummer: TGM-T34286-100mg
Description: Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1µM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively. Target: SGLT. Smiles: CCOC(=O)OC[C@H]1O[C@@H](Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@H](O)[C@@H](O)[C@@H]1O....
| Schlagworte: | GSK189075A, GSK-189075A, GSK 189075, GSK189075, GSK-189075, GSK 189075A |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 442201-24-3 |
| MW: | 522.59 D |
ab 34,00 €
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Artikelnummer: TGM-T4460-100mg
Description: Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of...
| Schlagworte: | Dapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrate |
| Anwendung: | Targets solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2, SGLT2) |
| CAS | 960404-48-2 |
| MW: | 502.98 D |
ab 45,00 €