Zu "K14290" wurden 39 Artikel gefunden!
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KPT276
Artikelnummer: TGM-T6074-10mg
Description: KPT276 (KPT 276) is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1. Target: CRM1. Smiles: FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)N2CC(F)(F)C2)n1. References: Ranganathan P, et al. Blood. 2012, 120(9), 1765-1773.
| Schlagworte: | KPT-276, KPT 276 |
| Anwendung: | Exportin 1 (XPO1/CRM1) inhibitor, antineoplastic |
| CAS | 1421919-75-6 |
| MW: | 426.26 D |
ab 47,00 €
Eltanexor
Artikelnummer: TGM-T11766L-100mg
Description: Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines. Target: Others....
| Schlagworte: | ATG-016, KPT-8602, ONO-7706 |
| Anwendung: | Targets exportin-1 (XPO1, CRM1) |
| CAS | 1642300-52-4 |
| MW: | 428.29 D |
ab 60,00 €
Leptomycin B
Artikelnummer: TGM-T15735-100mg
Description: Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Target: Antibiotic, Antifungal, CRM1. Smiles:...
| Schlagworte: | LMB, CI 940 |
| Anwendung: | Nuclear export blocker |
| CAS | 87081-35-4 |
| MW: | 540.73 D |
ab 212,00 €
Anti-Acetyl-XPO1 (K568)
Artikelnummer: CSB-PA000147.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-acetyl-CRM1, Anti-acetyl-Exp1, Anti-acetyl-XPO1, Anti-acetyl-Exportin-1, Anti-acetyl-Chromosome region maintenance 1... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-XPO1
Artikelnummer: CSB-PA360041.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: XPO1. Antigen Species: Human
| Schlagworte: | Anti-CRM1, Anti-Exp1, Anti-XPO1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog, Chromosome region... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Leptomycin B
Artikelnummer: Cay10004976-5
Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...
| Schlagworte: | Elactocin, LMB, Mantuamycin, NSC 364372,... |
| Anwendung: | Nuclear export blocker |
| CAS | 87081-35-4 |
| MW: | 540.7 D |
ab 49,00 €
Anti-CRM1
Artikelnummer: A300-469A
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 178,00 €
Verdinexor
Artikelnummer: Cay26171-1
Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities. It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively). Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of...
| Schlagworte: | KPT-335, (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide |
| Anwendung: | Nuclear export inhibitor, XPO1/CRM1 inhibitor |
| CAS | 1392136-43-4 |
| MW: | 442.3 D |
ab 40,00 €
KPT-276
Artikelnummer: Cay29158-5
KPT-276 is an orally bioavailable inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. In vivo, KPT-276 (150 mg/kg) increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia (AML) mouse xenograft model. It also reduces tumor volume and increases survival in...
| Schlagworte: | (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one |
| Anwendung: | Exportin 1 (XPO1/CRM1) inhibitor, antineoplastic |
| CAS | 1421919-75-6 |
| MW: | 426.3 D |
ab 94,00 €
Anti-CRM1
Artikelnummer: A300-490A
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-CRM1
Artikelnummer: NSJ-R32412
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mapped to human chromosome 2p16 by fluorescence in situ hybridization. This protein mediates leucine-rich nuclear export signal (NES)-dependent protein transport. It...
| Schlagworte: | Anti-CRM1, Anti-Exp1, Anti-XPO1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog, CRM1 Antibody |
| Anwendung: | WB, IHC (paraffin), IHC (frozen) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
772,00 €
Anti-CRM1 (IHC)
Artikelnummer: IHC-00139
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 178,00 €