Zu "K13806" wurden 28 Artikel gefunden!
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KT109
Artikelnummer: TGM-T27752-2mg
Description: KT109 is a selective inhibitor of DAGLbeta (IC50 = 42 nM). KT109-treated wild-type mice displayed reductions in LPS-induced allodyni as well as in DAGL-beta (-/-) micea. Repeated KT109 administration prevented the expression of LPS-induced allodynia, without evidence of tolerance. Intraplantar injection...
| Schlagworte: | KT-109, KT 109 |
| Anwendung: | DAGLB inhibitor |
| CAS | 1402612-55-8 |
| MW: | 422.52 D |
47,00 €
LEI-106
Artikelnummer: TGM-T27811-10mg
Description: LEI-106, a novel potent sn-1 DAGLalpha inhibitor, blocks the hydrolysis of sn-1-oleoyl-2-AG, inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6. Target: Others. Smiles: CC1(C)OC=2C(=CC(S(N(CC3=CC=C(OC4=CC=CC=C4)C=C3)CC(O)=O)(=O)=O)=CC2)CC1. References: Janssen FJ, Deng H, Baggelaar MP,...
| Anwendung: | DAGLalpha inhibitor |
| CAS | 1620582-23-1 |
| MW: | 481.56 D |
ab 110,00 €
O-7460
Artikelnummer: TGM-T35786-1mg
Description: In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLalpha (IC50 = 690 nM). It demonstrates much weaker inhibition towards human...
| Anwendung: | DAGL alpha inhibitor |
| CAS | 1572051-31-0 |
| MW: | 478.62 D |
ab 193,00 €
(R)-KT109
Artikelnummer: TGM-T38031-1mg
Description: (R)-KT109 is the (R) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLbeta (IC50 = 0.79 nM) and of DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with...
| Schlagworte: | (R)-KT109 |
| Anwendung: | Diacylglycerol lipase inhibitor |
| CAS | 2055172-60-4 |
| MW: | 422.52 D |
ab 228,00 €
(S)-KT109
Artikelnummer: TGM-T38148-1mg
Description: (S)-KT109 is the (S) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLbeta (IC50 = 39.81 nM), DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and alpha/beta-hydrolase domain-containing protein 6...
| Schlagworte: | (S)-KT109 |
| Anwendung: | Diacylglycerol lipase inhibitor |
| CAS | 2055172-61-5 |
| MW: | 422.52 D |
ab 228,00 €
KT172
Artikelnummer: TGM-T70756-10mg
Description: KT172, a DAGLbeta inhibitor, exhibits an IC50 value of 11 nM and has applications in metabolic and inflammatory research. Target: Others. Smiles: C(=O)(N1C(CC2=CC=CC=C2)CCCC1)N3C=C(N=N3)C4=CC=C(C=C4)C5=C(OC)C=CC=C5
| Anwendung: | Diacylglycerol lipase alpha (DAGL) alpha / beta inhibitor |
| CAS | 1402612-56-9 |
| MW: | 452.55 D |
ab 237,00 €
RHC 80267
Artikelnummer: TGM-T8236-100mg
Description: RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 µM in canine platelets. Target: COX, Acyltransferase, Phospholipase, Others, AChR. Smiles: O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1. References: Suzuki H , Kito Y , Fukuta H , et al. Effects of RHC-80267, an Inhibitor of...
| Schlagworte: | U-57908 |
| Anwendung: | DAG lipase inhibitor |
| CAS | 83654-05-1 |
| MW: | 394.51 D |
ab 32,00 €
KT109
Artikelnummer: Cay18933-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. KT109 is a selective inhibitor of DAGLbeta with an IC50 value of 42 nM. It demonstrates ~60-fold selectivity for DAGLbeta over...
| Schlagworte: | (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-methanone |
| Anwendung: | DAGLB inhibitor |
| CAS | 1402612-55-8 |
| MW: | 422.5 D |
ab 60,00 €
O-7460
Artikelnummer: Cay14009-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLalpha (IC50 = 690 nM). It demonstrates much weaker inhibition towards human...
| Schlagworte: | 2-[(fluoromethylphosphinyl)oxy]-1-[(1-methylethoxy)methyl]ethyl ester, 9Z-octadecenoic acid |
| Anwendung: | DAGL alpha inhibitor |
| CAS | 1572051-31-0 |
| MW: | 478.6 D |
ab 109,00 €
RHC-80267
Artikelnummer: Cay16432-10
RHC-80267 is an inhibitor of diacylglycerol lipase (DAGL, IC50 = 4 µM for the canine platelet enzyme). It also inhibits the serine hydrolases KIAA1363, fatty acid amide hydrolase (FAAH), BAT5, phospholipase A2 (PLA2), hormone-sensitive lipase (HSL), and acetylcholinesterase (AChE) by greater than 60% when used at a...
| Schlagworte: | U-57908, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime] |
| Anwendung: | DAG lipase inhibitor |
| CAS | 83654-05-1 |
| MW: | 394.5 D |
ab 42,00 €
LEI-106
Artikelnummer: Cay16419-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLalpha (IC50 = 18 nM). It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural...
| Schlagworte: | N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-glycine |
| Anwendung: | DAGLalpha inhibitor |
| CAS | 1620582-23-1 |
| MW: | 481.6 D |
ab 61,00 €
KT172
Artikelnummer: Cay19112-10
KT172 is a non-selective inhibitor of diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol (Cay-10008650) in HEK293T cell membranes expressing recombinant DAGLalpha or DAGLbeta (IC50s = 140 and 60 nM, respectively). KT172 also inhibits...
| Schlagworte: | [4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone |
| Anwendung: | Diacylglycerol lipase alpha (DAGL) alpha / beta inhibitor |
| CAS | 1402612-56-9 |
| MW: | 452.6 D |
ab 130,00 €