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Zu "K13806" wurden 28 Artikel gefunden!
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Artikelnummer: Cay18933-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. KT109 is a selective inhibitor of DAGLbeta with an IC50 value of 42 nM. It demonstrates ~60-fold selectivity for DAGLbeta over...
Schlagworte: | (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-methanone |
Anwendung: | DAGLB inhibitor |
CAS | 1402612-55-8 |
MW: | 422.5 D |
ab 60,00 €
Artikelnummer: Cay14009-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLalpha (IC50 = 690 nM). It demonstrates much weaker inhibition towards human...
Schlagworte: | 2-[(fluoromethylphosphinyl)oxy]-1-[(1-methylethoxy)methyl]ethyl ester, 9Z-octadecenoic acid |
Anwendung: | DAGL alpha inhibitor |
CAS | 1572051-31-0 |
MW: | 478.6 D |
ab 109,00 €
Artikelnummer: Cay16432-10
RHC-80267 is an inhibitor of diacylglycerol lipase (DAGL, IC50 = 4 µM for the canine platelet enzyme). It also inhibits the serine hydrolases KIAA1363, fatty acid amide hydrolase (FAAH), BAT5, phospholipase A2 (PLA2), hormone-sensitive lipase (HSL), and acetylcholinesterase (AChE) by greater than 60% when used at a...
Schlagworte: | U-57908, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime] |
Anwendung: | DAG lipase inhibitor |
CAS | 83654-05-1 |
MW: | 394.5 D |
ab 42,00 €
Artikelnummer: Cay16419-1
In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLalpha (IC50 = 18 nM). It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural...
Schlagworte: | N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-glycine |
Anwendung: | DAGLalpha inhibitor |
CAS | 1620582-23-1 |
MW: | 481.6 D |
ab 61,00 €
Artikelnummer: Cay19112-10
KT172 is a non-selective inhibitor of diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol (Cay-10008650) in HEK293T cell membranes expressing recombinant DAGLalpha or DAGLbeta (IC50s = 140 and 60 nM, respectively). KT172 also inhibits...
Schlagworte: | [4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone |
Anwendung: | Diacylglycerol lipase alpha (DAGL) alpha / beta inhibitor |
CAS | 1402612-56-9 |
MW: | 452.6 D |
ab 130,00 €
Artikelnummer: ARG64680.100
Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. [The UniProt Consortium]
Schlagworte: | Anti-DAGLA, Anti-C11orf11, Anti-DGL-alpha, EC=3.1.1.-, Anti-Sn1-specific diacylglycerol lipase alpha, Anti-Neural stem... |
Anwendung: | ELISA, WB |
Wirt: | Goat |
Spezies-Reaktivität: | human |
784,00 €
Artikelnummer: A304-480A
Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. [The UniProt Consortium]
Schlagworte: | Anti-DAGLB, Anti-KCCR13L, Anti-DGL-beta, EC=3.1.1.-, Anti-Sn1-specific diacylglycerol lipase beta |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: NSJ-R34954-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Diacylglycerol lipase alpha Protein function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for...
Schlagworte: | Anti-DAGLA, Anti-C11orf11, Anti-DGL-alpha, EC=3.1.1.-, Anti-Sn1-specific diacylglycerol lipase alpha, Anti-Neural stem... |
Anwendung: | WB, ELISA (peptide), IHC (paraffin) |
Wirt: | Goat |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: Cay25683-1
(S)-KT109 is the (S) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 (Cay-18933). (S)-KT109 is a less potent inhibitor of DAGLbeta (IC50 = 39.81 nM), DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and alpha/beta-hydrolase domain-containing protein 6...
Schlagworte: | (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2S)-2-(phenylmethyl)-1-piperidinyl]-methanone |
Anwendung: | Diacylglycerol lipase inhibitor |
CAS | 2055172-61-5 |
MW: | 422.5 D |
ab 125,00 €
Artikelnummer: Cay25682-1
(R)-KT109 is the (R) isomer of the diacylglycerol lipase beta (DAGLbeta) inhibitor KT109 (Cay-18933). (R)-KT109 is an inhibitor of DAGLbeta (IC50 = 0.79 nM) and of DAGLalpha-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (Cay-10008650, IC50 = 25.12 nM). It also inhibits alpha/beta-hydrolase...
Schlagworte: | (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2R)-2-(phenylmethyl)-1-piperidinyl]-methanone |
Anwendung: | Diacylglycerol lipase inhibitor |
CAS | 2055172-60-4 |
MW: | 422.5 D |
ab 125,00 €
Artikelnummer: ATA-HPA062497.100
Protein function: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain...
Schlagworte: | Anti-DAGLA, Anti-C11orf11, Anti-DGL-alpha, Anti-DAGL-alpha, Anti-Diacylglycerol lipase-alpha, Anti-Sn1-specific... |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 335,00 €
Artikelnummer: ATA-HPA069377.100
Protein function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid...
Schlagworte: | Anti-DAGLB, Anti-KCCR13L, Anti-DGL-beta, Anti-DAGL-beta, Anti-Diacylglycerol lipase-beta, Anti-PUFA-specific... |
Anwendung: | ICC, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 335,00 €