Zu "K13293" wurden 180 Artikel gefunden!
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(R)-(-)-Rolipram
Artikelnummer: TGM-T13448-10mg
Description: (R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor. Target: DNA-PK, Others. Smiles: COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1. References: Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct...
| Schlagworte: | (R)-Rolipram, (-)-Rolipram |
| Anwendung: | PDE4 inhibitor |
| CAS | 85416-75-7 |
| MW: | 275.34 D |
ab 39,00 €
Zardaverine
Artikelnummer: TGM-T17284-1mL
Description: Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction....
| Schlagworte: | BY 290, B 84290 |
| Anwendung: | PDE3 / PDE4 dual inhibitor |
| CAS | 101975-10-4 |
| MW: | 268.22 D |
ab 48,00 €
Dipyridamole
Artikelnummer: TGM-T1618-100mg
Description: Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation. Target: PDE. Smiles: N(CCO)(CCO)C1=NC2=C(C(=N1)N3CCCCC3)N=C(N(CCO)CCO)N=C2N4CCCCC4. References: Fujishige K, et al. J Biol Chem. 1999 Jun 25,274(26):18438-45.
| Schlagworte: | Dypyridamole, Dipyridamol, Persantin, NSC-515776, Dipyudamine |
| Anwendung: | Targets cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35] (PDE5) |
| CAS | 58-32-2 |
| MW: | 504.63 D |
ab 31,00 €
Tofimilast
Artikelnummer: TGM-T28991-100mg
Description: Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease. Target: PDE. Smiles: C(C)C=1C2=C(C=3N(C(=NN3)C4=CC=CS4)CC2)N(N1)C5CCCC5. References: Jaffari S, et al. Rapid characterisation of the inherent dispersibility of respirable...
| Schlagworte: | CP 325,366, CP 325366, CP325366, CP-325,366, CP-325366 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 185954-27-2 |
| MW: | 339.46 D |
ab 143,00 €
Apremilast
Artikelnummer: TGM-T2923-100mg
Description: Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities. Target: PDE, TNF, Apoptosis. Smiles: [C@H](CS(C)(=O)=O)(N1C(=O)C=2C(C1=O)=CC=CC2NC(C)=O)C3=CC(OCC)=C(OC)C=C3. References: Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4...
| Schlagworte: | CC-10004 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 608141-41-9 |
| MW: | 460.5 D |
ab 43,00 €
Difamilast
Artikelnummer: TGM-T27172-100mg
Description: Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM). Target: PDE. Smiles: CCOc1ccccc1C(=O)NCc1coc(n1)-c1ccc(OC(F)F)c(OC(C)C)c1. References: Ahluwalia J, et, al. Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis:...
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 937782-05-3 |
| MW: | 446.44 D |
ab 129,00 €
GSK356278
Artikelnummer: TGM-T27475-100mg
Description: GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognition-enhancing effects. Target: PDE. Smiles:...
| Schlagworte: | GSK-356278, GSK 356278 |
| Anwendung: | Potent, selective PDE4 inhibitor |
| CAS | 720704-34-7 |
| MW: | 439.53 D |
ab 34,00 €
O-Demethyl Apremilast
Artikelnummer: TGM-T35929-10mg
Description: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 8.3 and 5.6 µM, respectively)....
| Anwendung: | Apremilast active metabolite, PDE4 inhibitor |
| CAS | 1384441-38-6 |
| MW: | 446.47 D |
ab 151,00 €
Phosphodiesterase 4 Inhibitor
Artikelnummer: TGM-T36018-10mg
Description: Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 µM for the human recombinant enzyme. Target: Others. Smiles: CC=1N(N=C(C)C1C(OCC)=O)C2=CC(N(=O)=O)=CC=C2
| Anwendung: | PDE4 inhibitor |
| CAS | 346440-86-6 |
| MW: | 289.29 D |
ab 321,00 €
Tanimilast
Artikelnummer: TGM-T38625-100mg
Description: Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease. Target: PDE....
| Schlagworte: | CHF-6001 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 1239278-59-1 |
| MW: | 687.54 D |
ab 274,00 €
CP671305
Artikelnummer: TGM-T4695-100mg
Description: CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D. Target: PDE. Smiles: C[C@@H](Oc1ccc(CNC(=O)c2cccnc2Oc2ccc3OCOc3c2)c(F)c1)C(O)=O. References: Kalgutkar AS, et al. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor...
| Anwendung: | PDE4D inhibitor |
| CAS | 445295-04-5 |
| MW: | 454.4 D |
ab 32,00 €
Crisaborole
Artikelnummer: TGM-T4285-100mg
Description: Crisaborole (AN-2728) is a phosphodiesterase 4 inhibitor. Target: PDE. Smiles: OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12. References: Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic...
| Schlagworte: | PF-06930164, AN-2728 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 906673-24-3 |
| MW: | 251.05 D |
ab 38,00 €