Zu "K13293" wurden 192 Artikel gefunden!
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Anti-PDE4D
Artikelnummer: ABS-KC-3187.100
Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. [The UniProt Consortium]
| Schlagworte: | Anti-cAMP-specific 3', Anti-5'-cyclic phosphodiesterase 4D, Anti-DPDE3, Anti-PDE43, PDE4D Antibody |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Rolipram
Artikelnummer: TGM-T6644-50mg
Description: Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties. Target: HIV Protease, Antibacterial, PDE. Smiles: O(C1=C(OC)C=CC(=C1)C2CNC(=O)C2)C3CCCC3. References: MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the...
| Schlagworte: | (R,S)-Rolipram, ZK 62711, SB 95952 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 61413-54-5 |
| MW: | 275.34 D |
ab 43,00 €
Tofimilast
Artikelnummer: TGM-T28991-100mg
Description: Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease. Target: PDE. Smiles: C(C)C=1C2=C(C=3N(C(=NN3)C4=CC=CS4)CC2)N(N1)C5CCCC5. References: Jaffari S, et al. Rapid characterisation of the inherent dispersibility of respirable...
| Schlagworte: | CP 325,366, CP 325366, CP325366, CP-325,366, CP-325366 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 185954-27-2 |
| MW: | 339.46 D |
ab 145,00 €
Apremilast
Artikelnummer: TGM-T2923-100mg
Description: Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities. Target: PDE, TNF, Apoptosis. Smiles: [C@H](CS(C)(=O)=O)(N1C(=O)C=2C(C1=O)=CC=CC2NC(C)=O)C3=CC(OCC)=C(OC)C=C3. References: Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4...
| Schlagworte: | CC-10004 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 608141-41-9 |
| MW: | 460.5 D |
ab 43,00 €
Difamilast
Artikelnummer: TGM-T27172-100mg
Description: Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM). Target: PDE. Smiles: CCOc1ccccc1C(=O)NCc1coc(n1)-c1ccc(OC(F)F)c(OC(C)C)c1. References: Ahluwalia J, et, al. Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis:...
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 937782-05-3 |
| MW: | 446.44 D |
ab 62,00 €
GSK356278
Artikelnummer: TGM-T27475-100mg
Description: GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognition-enhancing effects. Target: PDE. Smiles:...
| Schlagworte: | GSK-356278, GSK 356278 |
| Anwendung: | Potent, selective PDE4 inhibitor |
| CAS | 720704-34-7 |
| MW: | 439.53 D |
ab 34,00 €
O-Demethyl Apremilast
Artikelnummer: TGM-T35929-10mg
Description: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 8.3 and 5.6 µM, respectively)....
| Anwendung: | Apremilast active metabolite, PDE4 inhibitor |
| CAS | 1384441-38-6 |
| MW: | 446.47 D |
ab 154,00 €
Phosphodiesterase 4 Inhibitor
Artikelnummer: TGM-T36018-10mg
Description: Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 µM for the human recombinant enzyme. Target: Others. Smiles: CC=1N(N=C(C)C1C(OCC)=O)C2=CC(N(=O)=O)=CC=C2
| Anwendung: | PDE4 inhibitor |
| CAS | 346440-86-6 |
| MW: | 289.29 D |
ab 327,00 €
Filaminast
Artikelnummer: TGM-T31792-100mg
Description: Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug. Target: PDE. Smiles: O(C1=C(OC)C=CC(\C(=N\OC(N)=O)\C)=C1)C2CCCC2. References: Kalinina OV, et al. Combinations of protein-chemical complex structures reveal...
| Schlagworte: | CDD69JC61J, WAY-PDA 641, Way-pda-641, UNII-CDD69JC61J |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 141184-34-1 |
| MW: | 292.33 D |
ab 237,00 €
Tanimilast
Artikelnummer: TGM-T38625-100mg
Description: Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease. Target: PDE....
| Schlagworte: | CHF-6001 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 1239278-59-1 |
| MW: | 687.54 D |
ab 233,00 €
Lotamilast
Artikelnummer: TGM-T3987-100mg
Description: Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis. Target: PDE. Smiles: CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1. References: Nemoto O., et al. Effect of topical phosphodiesterase 4 inhibitor E6005 on...
| Schlagworte: | RVT-501, E6005 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 947620-48-6 |
| MW: | 472.49 D |
ab 30,00 €
CP671305
Artikelnummer: TGM-T4695-100mg
Description: CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D. Target: PDE. Smiles: C[C@@H](Oc1ccc(CNC(=O)c2cccnc2Oc2ccc3OCOc3c2)c(F)c1)C(O)=O. References: Kalgutkar AS, et al. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor...
| Anwendung: | PDE4D inhibitor |
| CAS | 445295-04-5 |
| MW: | 454.4 D |
ab 31,00 €