Zu "K12800" wurden 105 Artikel gefunden!
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Anti-NLRP3/NALP3, clone Cryo-2
Artikelnummer: AG-20B-0014-C100
Recognizes mouse and human NLRP3/NALP3. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the...
| Schlagworte: | NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein |
| Anwendung: | IHC, IP, WB, ICC, ChIP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human , mouse |
374,00 €
NEU
JC2-11
Artikelnummer: Cay41595-10
JC2-11 is an inflammasome inhibitor. It inhibits increases in IL-1beta production induced by the NOD-like receptor protein 3 (NLRP3) activators ATP (Cay-14498, Cay-40182), nigericin (Cay-11437), or monosodium urate crystals in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs) when used at...
| Schlagworte: | 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-2-propen-1-one |
| Anwendung: | Inflammasome inhibitor |
| CAS | 937820-89-8 |
| MW: | 302.3 D |
ab 116,00 €
YQ128
Artikelnummer: TGM-T13375-100mg
Description: YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 µM and exhibits significant anti-inflammatory activity. Target: Interleukin, NOD-like Receptor (NLR), NOD, IL Receptor. Smiles:...
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 2454246-18-3 |
| MW: | 545.11 D |
ab 51,00 €
NLRP3-IN-2
Artikelnummer: TGM-T3230-100mg
Description: NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on...
| Schlagworte: | 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide, NLRP3 Inflammasome Inhibitor I |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 16673-34-0 |
| MW: | 368.84 D |
ab 41,00 €
MCC950
Artikelnummer: TGM-T3701-100mg
Description: CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1beta secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically...
| Schlagworte: | CP-456773 |
| Anwendung: | NLRP3 inhibitor |
| CAS | 210826-40-7 |
| MW: | 404.48 D |
ab 42,00 €
INF39
Artikelnummer: TGM-T4217-100mg
Description: INF39 is a noncytotoxic and irreversible NLRP3 inhibitor. Target: NOD-like Receptor (NLR), NOD. Smiles: CCOC(=O)C(=C)Cc1ccccc1Cl. References: Cocco M, et al. J Med Chem. 2017, 60(9):3656-3671.
| Anwendung: | Irreversible NLRP3 inflammasome inhibitor |
| CAS | 866028-26-4 |
| MW: | 224.68 D |
ab 55,00 €
Uric acid sodium
Artikelnummer: TGM-T41242-100mg
Description: Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, has an inhibitory effect on lipid...
| Anwendung: | NLRP3/NALP3 inflammasome activator |
| CAS | 1198-77-2 |
| MW: | 190.09 D |
ab 31,00 €
CY-09
Artikelnummer: TGM-T4164-100mg
Description: CY-09 is an NLRP3 inhibitor. Target: NOD, NOD-like Receptor (NLR). Smiles: OC(=O)c1ccc(C=C2SC(=S)N(Cc3cccc(c3)C(F)(F)F)C2=O)cc1. References: Jiang H, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017 Nov 6,214(11):3219-3238.
| Schlagworte: | CY 09 |
| Anwendung: | NLRP3 inhibitor |
| CAS | 1073612-91-5 |
| MW: | 423.43 D |
ab 47,00 €
MCC950 sodium
Artikelnummer: TGM-T6887-100mg
Description: MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs, IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2, NLRC4 or NLRP1. Target: NOD, NOD-like Receptor (NLR). Smiles:...
| Schlagworte: | MCC950, CP-456773 sodium, CP-456773, CRID3 sodium salt |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426.46 D |
ab 31,00 €
RRX-001
Artikelnummer: TGM-T7400-100mg
Description: RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity. Target: Dehydrogenase, Apoptosis, Parasite. Smiles: [O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O. References: Zhao H , Ning S , Nolley R , et al. The immunomodulatory anticancer agent, RRx-001,...
| Anwendung: | Targets NACHT, LRR and PYD domains-containing protein 3 (NLRP3, PYPAF1) |
| CAS | 925206-65-1 |
| MW: | 268.02 D |
ab 48,00 €
NT-0796
Artikelnummer: TGM-T81637-50mg
Description: NT-0796 is a brain-permeable, potent, and selective inhibitor of the inflammasome NLRP3, inhibiting NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector. Target: NOD. Smiles: N(C(O[C@H](CC=1N=CC=CN1)C(OC(C)C)=O)=O)C2=C3C(=CC4=C2CCC4)CCC3
| Schlagworte: | NT0796, NT 0796 |
| Anwendung: | NLRP3 inflammasome inhibitor, NDT-19795 prodrug form |
| CAS | 2272917-13-0 |
| MW: | 409.48 D |
ab 192,00 €
BMS986299
Artikelnummer: TGM-T9572-10mg
Description: BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 µM and can be used in studies about NLRP3 signaling and the treatment of associated diseases. Target: NOD. Smiles: NC=1C2=C(C=3C(=CC(=CC3)C=4C=CNN4)N1)NC(CN(C(C)=O)CC)=N2. References: Gary Glick, et al. Substituted imidazo-quinolines as nlrp3...
| Schlagworte: | Unii-VS58MO4P47 |
| Anwendung: | NLRP3 inflammasome agonist |
| CAS | 2242952-69-6 |
| MW: | 349.39 D |
ab 39,00 €