Zu "K12654" wurden 148 Artikel gefunden!
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NEU
STING Y240A variant (Y240A mutant, human, recombinant)
Artikelnummer: Cay40240-100
Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I...
| Schlagworte: | ERIS, ERIS, hMITA, hMITA, hSTING, hSTING, Transmembrane protein 173, Transmembrane protein 173, Mediator of IRF3... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
806,00 €
CAY10748
Artikelnummer: TGM-T36461-10mg
Description: CAY10748 is an agonist of stimulator of interferon genes (STING, IC50= 0.3794 µM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine...
| Schlagworte: | CAY10748 |
| Anwendung: | STING stimulator |
| CAS | 2412902-55-5 |
| MW: | 591.66 D |
ab 120,00 €
Cyclic-di-GMP disodium
Artikelnummer: TGM-T36983-10mg
Description: Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing...
| Schlagworte: | 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic diguanylate, c-di-GMP, Cyclic di-GMP (sodium salt), cyclic... |
| Anwendung: | Second messenger in bacteria |
| CAS | 2222132-40-1 |
| MW: | 734.38 D |
ab 136,00 €
STING Agonist 12b
Artikelnummer: TGM-T38159-10mg
Description: STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 µM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively). STING agonist 12b (40 µM) induces expression of TNF-a, IL-6,...
| Anwendung: | Stimulator of interferon genes protein activator |
| CAS | 2411100-70-2 |
| MW: | 253.3 D |
ab 120,00 €
STING Agonist 1a
Artikelnummer: TGM-T38160-10mg
Description: STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1...
| Anwendung: | Stimulator of interferon genes protein activator |
| CAS | 652142-94-4 |
| MW: | 396.23 D |
ab 120,00 €
C-176
Artikelnummer: TGM-T5154-100mg
Description: C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNbeta production and possesses anti-inflammatory activity. Target: STING. Smiles: [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1. References: Haag SM, et al. Targeting STING with...
| Schlagworte: | STING inhibitor 1, C176 |
| Anwendung: | Covalent STING inhibitor |
| CAS | 314054-00-7 |
| MW: | 358.09 D |
ab 31,00 €
diABZI STING agonist-1 trihydrochloride
Artikelnummer: TGM-T5516-100mg
Description: diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist. Target: STING. Smiles: Cl.Cl.Cl.CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCN3CCOCC3)c12)C(N)=O)C(N)=O. References: Ramanjulu JM, et al. Design of amidobenzimidazole...
| Anwendung: | Stimulator of interferon genes pathway agonist |
| CAS | 2138299-34-8 |
| MW: | 959.32 D |
ab 171,00 €
H-151
Artikelnummer: TGM-T5674-100mg
Description: H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo. Target: STING. Smiles:...
| Anwendung: | STING inhibitor |
| CAS | 941987-60-6 |
| MW: | 279.34 D |
ab 31,00 €
C-178
Artikelnummer: TGM-T7329-100mg
Description: C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. Target: STING. Smiles: [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2c(c1)oc1ccccc21. References: Haag S M , Gulen M F , Luc R , et al. Targeting STING...
| Anwendung: | Covalent STING inhibitor |
| CAS | 329198-87-0 |
| MW: | 322.27 D |
ab 37,00 €
MSA-2
Artikelnummer: TGM-T8798-100mg
Description: MSA-2 is a potent and orally available non-nucleotide STING agonist. Target: STING. Smiles: COc1cc2cc(sc2cc1OC)C(=O)CCC(O)=O. References: Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020,369(6506):eaba6098.
| Anwendung: | STING agonist |
| CAS | 129425-81-6 |
| MW: | 294.32 D |
ab 34,00 €
SR-717
Artikelnummer: TGM-T8655-100mg
Description: SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. Target: STING. Smiles: [Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1....
| Anwendung: | STING agonist |
| CAS | 2375421-09-1 |
| MW: | 351.19 D |
ab 74,00 €
STING agonist-1
Artikelnummer: TGM-T8328-100mg
Description: STING agonist-1 (G10) is a human-specific agent that elicits antiviral activity against emerging Alphaviruses. Target: STING, Virus Protease. Smiles: Fc1cccc(Cl)c1CN1C(=O)CSc2ccc(cc12)C(=O)NCc1ccco1. References: Sali TM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits...
| Schlagworte: | G10 |
| Anwendung: | STING agonist |
| CAS | 702662-50-8 |
| MW: | 430.88 D |
ab 31,00 €