Zu "K12654" wurden 120 Artikel gefunden!
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NEU
Stimulator of interferon genes protein (Sting1), mouse,...
Artikelnummer: CSB-CF023754MO.100
Organism: Mus musculus (Mouse). Source: in vitro E.coli expression system. Expression Region: 1-378aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MPYSNLHPAI PRPRGHRSKY VALIFLVASL MILWVAKDPP NHTLKYLALH LASHELGLLL KNLCCLAEEL CHVQSRYQGS YWKAVRACLG...
| Schlagworte: | ERIS, MMITA, mSTING, Transmembrane protein 173, Mediator of IRF3 activation, Stimulator of interferon genes protein,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | mouse |
| MW: | 48.9 kD |
ab 1.413,00 €
NEU
Human TMEM173 Protein, hFc Tag
Artikelnummer: DIM-PME100542.100
Recombinant human TMEM173 protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) TMEM173 (Leu139-Ser379), Protein function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta)...
| Schlagworte: | ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING, STING-beta, TMEM173 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 53.2 kD |
ab 115,00 €
NEU
SARS-CoV-2 (Alpha) S protein RBD , hFc Tag
Artikelnummer: DIM-PME100543.10
Recombinant SARS-CoV-2 S protein RBD(N501Y) protein with C-terminal human Fc tag. S protein RBD(N501Y)(Arg319-Phe541) hFc(Glu99-Ala330), Protein function: [Spike protein S1]: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2...
| Schlagworte: | SARS-CoV-2 B.1.1.7 (Alpha) Spike RBD Protein |
| Exprimiert in: | Human cells |
| Ursprungsart: | SARS-CoV-2 |
| MW: | 51.3 kD |
ab 109,00 €
NEU
STING1 (human) full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP100040.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Schlagworte: | ERIS, hMITA, hSTING, Transmembrane protein 173, Mediator of IRF3 activation, Stimulator of interferon genes protein,... |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 42.2 kD |
ab 1.260,00 €
NEU
Anti-TMEM173
Artikelnummer: CSB-PA005903.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ERIS, Anti-hMITA, Anti-hSTING, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
106,00 €
NEU
Anti-TMEM173 Recombinant Monoclonal, clone 7C7
Artikelnummer: CSB-RA843206A0HU.100
Isotype: Rabbit IgG. Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity-chromatography. Target Name: TMEM173. Antigen Species: Human
| Schlagworte: | Anti-ERIS, Anti-hMITA, Anti-hSTING, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of... |
| Anwendung: | ELISA, WB, |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 201,00 €
NVS-STG2
Artikelnummer: Cay40159-1
NVS-STG2 is an agonist of stimulator of interferon genes (STING). It binds to STING and induces STING activation in a reporter assay (IC50 = 5.2 µM). Intratumoral injection of NVS-STG2 (400 or 800 µg/animal) reduces tumor volume and increases intratumoral IFN-gamma levels in a B16.SIY murine melanoma model.Formal...
| Schlagworte: | 4-((4-(2-(tert-butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid |
| Anwendung: | STING agonist |
| MW: | 427.5 D |
ab 168,00 €
STING R232 variant (N242A mutant, human, recombinant)
Artikelnummer: Cay40241-100
Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I...
| Schlagworte: | ERIS, ERIS, hMITA, hMITA, hSTING, hSTING, Transmembrane protein 173, Transmembrane protein 173, Mediator of IRF3... |
| Anwendung: | Active protein |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
790,00 €
PDIC-NC
Artikelnummer: Cay40818-1
PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent. It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM. PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml,...
| Schlagworte: | 5,6,12,13-tetrachloro-2,9-bis[2-(dimethylamino)ethyl]-anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetron... |
| Anwendung: | STING activator, anticancer agent |
| CAS | 2633013-75-7 |
| MW: | 743.3 D |
ab 35,00 €
PDIC-NS
Artikelnummer: Cay40481-1
PDIC-NS is an activator of stimulator of interferon genes (STING). It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial...
| Anwendung: | STING activator |
| MW: | 862.6 D |
ab 34,00 €
STING PROTAC SP23
Artikelnummer: Cay39274-1
STING PROTAC SP23 is a proteolysis-targeting chimera (PROTAC) containing the stimulator of interferon genes (STING) inhibitor C-170 (Cay-30157) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alpha,beta-unsaturated carbonyl linker. It degrades STING in THP-1 cells with a half-maximal...
| Schlagworte: | PROTAC Stimulator of Interferon Genes Degrader-1, PROTAC STING Degrader-1, Proteolysis-targeting Chimera Stimulator of... |
| Anwendung: | STING degradation driving PROTAC |
| CAS | 2762552-74-7 |
| MW: | 699.7 D |
181,00 €
BDW568
Artikelnummer: Cay39708-1
BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.Formal...
| Schlagworte: | 2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]-acetic acid, methyl ester |
| Anwendung: | STING agonist, BDW-OH prodrug |
| CAS | 335401-44-0 |
| MW: | 308.4 D |
ab 80,00 €