Zu "K12407" wurden 61 Artikel gefunden!
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AZD 1656
Artikelnummer: Cay41839-1
AZD 1656 is an activator of hexokinase-4 (HK4). It activates HK4 and induces glucose phosphorylation in a cell-free assay (EC50 = 61 nM). AZD 1656 (0.3 mg/kg) decreases blood glucose levels in an oral glucose tolerance test (OGTT) in rats. It reduces blood glucose levels and increases plasma insulin levels in mice...
| Schlagworte: | 3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-benzamide |
| Anwendung: | Hexokinase-4 (HK4, Glucokinase) activator |
| CAS | 919783-22-5 |
| MW: | 478.5 D |
ab 75,00 €
Globalagliatin
Artikelnummer: TGM-T3104-10mg
Description: Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2. Target: Glucokinase. Smiles: O=C(Nc1ncc(SCCN2CCCC2)s1)[C@@]1(C[C@H]1C1CCCCC1)c1ccc(cc1)S(=O)(=O)C1CC1. References: Gupta, M., & Vadde, R. (2019). Insights into the structure-function relationship of...
| Schlagworte: | LY2608204 |
| Anwendung: | Glucokinase activator |
| CAS | 1234703-40-2 |
| MW: | 559.81 D |
ab 33,00 €
Cadisegliatin
Artikelnummer: TGM-T62821-100mg
Description: Cadisegliatin (TTP-399) is a liver-selective glucose kinase (GK) activator with hypoglycemic effects, useful for studying type 2 diabetes. Target: Others. Smiles: CCCO[C@H]1CC[C@@H](CC1)N(C1CCCCC1)C(=O)Nc1ncc(SCC(O)=O)s1
| Anwendung: | Targets glucokinase [EC:2.7.1.2] (GCK) |
| CAS | 859525-02-3 |
| MW: | 455.63 D |
ab 916,00 €
Piragliatin
Artikelnummer: TGM-T68976-100mg
Description: Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus....
| Anwendung: | Targets glucokinase [EC:2.7.1.2] (GCK) |
| CAS | 625114-41-2 |
| MW: | 421.9 D |
ab 1.671,00 €
Glucokinase Protein, Human, Recombinant
Artikelnummer: TGM-TMPY-04394-50ug
Description: Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells...
| Schlagworte: | glucokinase (hexokinase 4), HXKP, MODY2, FGQTL3, LGLK, GLK, HKIV, HHF3, GK, HK4 |
| MW: | 52.2 kD |
497,00 €
Dorzagliatin
Artikelnummer: TGM-T15159-100mg
Description: Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic beta-cell function in type 2 diabetes. Target: Glucokinase. Smiles: CC(C)C[C@H](N1CC(Oc2ccccc2Cl)=CC1=O)C(=O)Nc1ccn(C[C@@H](O)CO)n1. References: Zhu XX, et al. Dorzagliatin (HMS5552), a...
| Schlagworte: | HMS5552 |
| Anwendung: | Targets glucokinase [EC:2.7.1.2] (GCK) |
| CAS | 1191995-00-2 |
| MW: | 462.93 D |
ab 34,00 €
Anti-GCK
Artikelnummer: CSB-PA002656.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, ATP:D-hexose... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
126,00 €
Anti-GCK
Artikelnummer: CSB-PA138466.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GCK. Antigen Species: Human
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, ATP:D-hexose... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-GCK
Artikelnummer: CSB-PA211635.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GCK. Antigen Species: Human
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, ATP:D-hexose... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-GCK
Artikelnummer: CSB-PA552215.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GCK. Antigen Species: Human
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, ATP:D-hexose... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-GCK
Artikelnummer: CSB-PA594444.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GCK. Antigen Species: Human
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, ATP:D-hexose... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
D-Glucose-6-phosphate (sodium salt)
Artikelnummer: Cay20376-500
D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis. It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate...
| Schlagworte: | G6P, Sodium Glucose-6-Phosphate, D-glucose-6-(dihydrogen phosphate), monosodium salt |
| Anwendung: | Glycolysis / pentose phosphate pathway / glycogen synthesis starting molecule |
| CAS | 54010-71-8 |
| MW: | 282.1 D |
ab 44,00 €