Zu "K11987" wurden 346 Artikel gefunden!
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COX Fluorescent Inhibitor Screening Assay Kit
Artikelnummer: Cay700100-192
Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the...
| Schlagworte: | Cyclooxygenase Fluorescent Inhibitor Screening Assay Kit |
| Anwendung: | COX inhibitor screening |
895,00 €
COX-2 (human) Inhibitor Screening Assay Kit
Artikelnummer: Cay701080-96
The COX-2 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride (SnCl2) reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-2 and is an excellent...
| Schlagworte: | Cyclooxygenase 2 |
| Anwendung: | Inhibitor screening |
584,00 €
Anti-COX-2 (Clone CX229)
Artikelnummer: Cay160112-1
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the hydroperoxy endoperoxide...
| Schlagworte: | Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2 |
| Anwendung: | IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, ovine, monkey |
422,00 €
NEU
Fenclofenac
Artikelnummer: Cay41709-1
Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 µM for COX-1 and COX-2, respectively). It reduces paw volume in a rat model of adjuvant-induced polyarthritis when administered at doses of 3, 15, and 75 mg/kg and reverses yeast-induced motor impairments, a measure of...
| Schlagworte: | RX-67408, 2-(2,4-dichlorophenoxy)-benzeneacetic acid |
| Anwendung: | NSAID, COX inhibitor |
| CAS | 34645-84-6 |
| MW: | 297.1 D |
ab 35,00 €
Inotilone
Artikelnummer: TGM-T21808-1mg
Description: Inotilone is a major component of Inonotus linteus, a traditional Chinese medical herb and can be used for research of metastatic lung cancer cells. Target: Others. Smiles: C(=C/1\OC(C)=CC1=O)\C2=CC(O)=C(O)C=C2. References: Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis...
| Anwendung: | COX-2 inhibitor |
| CAS | 906366-79-8 |
| MW: | 218.21 D |
ab 48,00 €
Cimicoxib
Artikelnummer: TGM-T30937-100mg
Description: Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity. Target: COX. Smiles: ClC1=C(N(C=N1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=C(OC)C=C3. References: Kim TW, et al. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Vet...
| Schlagworte: | trade name: Cimalgex, UR8880, UR-8880 |
| Anwendung: | COX-2 inhibitor |
| CAS | 265114-23-6 |
| MW: | 381.81 D |
ab 39,00 €
NS-398
Artikelnummer: TGM-T3214-100mg
Description: NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity. Target: COX. Smiles: CS(=O)(=O)Nc1cc(ccc1OC1CCCCC1)[N+]([O-])=O. References: Futaki N, et al. Prostaglandins. 1994, 47(1):55-9.
| Schlagworte: | N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide, NS398 |
| Anwendung: | COX-2 inhibitor |
| CAS | 123653-11-2 |
| MW: | 314.36 D |
ab 31,00 €
CAY10416
Artikelnummer: TGM-T36457-10mg
Description: Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2...
| Anwendung: | COX-2 inhibitor, 5-LO inhibitor |
| CAS | 443919-96-8 |
| MW: | 536.61 D |
ab 140,00 €
Chrysin
Artikelnummer: TGM-T2837-1g
Description: Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. Target: Antioxidant, Estrogen Receptor/ERR. Smiles: OC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1. References: Mani R , Natesan V ....
| Schlagworte: | 5, 7-Dihydroxyflavone, 5,7-Dihydroxyflavone, NSC 407436 |
| Anwendung: | Antioxidant, antiinflammatory, anticancer compound, COX-2 gene expression inhibitor |
| CAS | 480-40-0 |
| MW: | 254.24 D |
ab 42,00 €
5'-hydroxy Meloxicam
Artikelnummer: TGM-T37195-1mg
Description: 5'-hydroxy Meloxicam is one of the metabolites of meloxicam (MEL). Target: Others. Smiles: CN1C(C(=O)Nc2ncc(CO)s2)=C(O)c2ccccc2S1(=O)=O , t:13,
| Anwendung: | Metabolite |
| CAS | 130262-92-9 |
| MW: | 367.39 D |
ab 318,00 €
Diclofenac methyl ester
Artikelnummer: TGM-T37482-100mg
Description: Diclofenac methyl ester is a hydrophobic prodrug form of diclofenac which is a non-steroidal anti-inflammatory drug (NSAID). Diclofenac methyl ester is more soluble than diclofenac acid in isopropylmyristate but with higher toxicity. Target: Others. Smiles: COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl. References:...
| Anwendung: | Antiinflammatory, analgesic, COX inhibitor |
| CAS | 15307-78-5 |
| MW: | 310.18 D |
ab 35,00 €
![[10]-Shogaol](https://www.biomol.com/media/image/8b/30/c1/TGM-T5431-1mg_200x200.png "[10]-Shogaol")
[10]-Shogaol
Artikelnummer: TGM-T5431-100mg
Description: [10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects. Target: COX, Antioxidant. Smiles: CCCCCCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1. References: Min BR, et al. Effects of Tissue Culture and Mycorrhiza...
| Schlagworte: | 10-Shogaol |
| Anwendung: | Bioactive phenol |
| CAS | 36752-54-2 |
| MW: | 332.48 D |
ab 82,00 €