Zu "K11843" wurden 45 Artikel gefunden!
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B-AP15
Artikelnummer: TGM-T1932-100mg
Description: B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Target: DUB, Apoptosis. Smiles: C(=C\1/C(=O)\C(=C\C2=CC=C(N(=O)=O)C=C2)\CN(C(C=C)=O)C1)\C3=CC=C(N(=O)=O)C=C3....
| Schlagworte: | NSC 687852 |
| Anwendung: | USP14 / UCHL5 inhibitor |
| CAS | 1009817-63-3 |
| MW: | 419.39 D |
ab 33,00 €
IU1-47
Artikelnummer: TGM-T15604-100mg
Description: IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 µM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 µM). Target: DUB. Smiles: Cc1cc(C(=O)CN2CCCCC2)c(C)n1-c1ccc(Cl)cc1. References: Boselli M, et al. An inhibitor of the proteasomal deubiquitinating...
| Anwendung: | USP14 inhibitor |
| CAS | 670270-31-2 |
| MW: | 330.85 D |
ab 51,00 €
VLX1570
Artikelnummer: TGM-T4067-100mg
Description: VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 ranging from 4.2 µM to 8.6 µM, and exhibits potent inhibition of USP14. Target: DUB. Smiles: [O-][N+](=O)c1cc(\C=C2\CCN(C\C(=C\c3ccc(F)c(c3)[N+]([O-])=O)C2=O)C(=O)C=C)ccc1F. References: Wang X et al. Synthesis and evaluation of...
| Anwendung: | 19S proteasomal deubiquitinase inhibitor |
| CAS | 1431280-51-1 |
| MW: | 469.39 D |
ab 95,00 €
IU1
Artikelnummer: TGM-T6107-100mg
Description: IU1(IC50=4.7 µ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell. Target: DUB, Autophagy. Smiles: Cc1c(ccn1-c1ccc(F)cc1)C(=O)CN1CCCC1. References: Byung-Hoon L, et al. Nature, 2010, 467(7312), 179-184.
| Anwendung: | Deubiquitination inhibitor |
| CAS | 314245-33-5 |
| MW: | 300.37 D |
ab 53,00 €
Anti-USP14 Recombinant Monoclonal, clone 28C4
Artikelnummer: CSB-RA587609A0HU.100
Isotype: Rabbit IgG. Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity-chromatography. Target Name: USP14. Antigen Species: Human
| Schlagworte: | Anti-TGT, Anti-USP14, EC=3.4.19.12, Anti-Ubiquitin thioesterase 14, Anti-Deubiquitinating enzyme 14, Anti-Ubiquitin... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 201,00 €
Ubiquitin carboxyl-terminal hydrolase 14 (USP14), human,...
Artikelnummer: CSB-EP025704HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-494aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV QCIRSVPELK...
| Schlagworte: | TGT, USP14, EC=3.4.19.12, Ubiquitin thioesterase 14, Deubiquitinating enzyme 14, Ubiquitin carboxyl-terminal hydrolase 14,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 60.1 kD |
ab 213,00 €
IU1
Artikelnummer: Cay10617-10
Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein conjugates. IU1 is a reversible, small molecule inhibitor of...
| Schlagworte: | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone |
| Anwendung: | Deubiquitination inhibitor |
| CAS | 314245-33-5 |
| MW: | 300.4 D |
ab 52,00 €
Anti-USP14
Artikelnummer: A300-920A
Protein function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell....
| Schlagworte: | Anti-TGT, Anti-USP14, EC=3.4.19.12, Anti-Ubiquitin thioesterase 14, Anti-Deubiquitinating enzyme 14, Anti-Ubiquitin... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
WP1130
Artikelnummer: Cay15227-5
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases...
| Schlagworte: | Degrasyn, (2E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[1S-phenylbutyl]-2-propenamide |
| Anwendung: | Tyrphostin derivate, Deubiquitinase activity inhibitor |
| CAS | 856243-80-6 |
| MW: | 384.3 D |
ab 92,00 €
Anti-USP14
Artikelnummer: A300-919A
Protein function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell....
| Schlagworte: | Anti-TGT, Anti-USP14, EC=3.4.19.12, Anti-Ubiquitin thioesterase 14, Anti-Deubiquitinating enzyme 14, Anti-Ubiquitin... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
USP14, active human recombinant protein, N-terminal FLAG-tag
Artikelnummer: BPS-80364
Human USP14 (Ubiquitin-Specific Protease 14) or TGT (tRNA-guanine transglycosylase), GenBank Accession No. NM_005151, amino-acids 2-494(end) with an N-terminal FLAG-tag, MW=57 kDa, expressed in a baculovirus-infected Sf9 cell expression system.
| Schlagworte: | TGT, USP14, EC=3.4.19.12, Ubiquitin thioesterase 14, Deubiquitinating enzyme 14, Ubiquitin carboxyl-terminal hydrolase 14,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 57 kD |
628,00 €
b-AP15
Artikelnummer: Cay11324-1
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin. b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. It...
| Schlagworte: | 3E,5E-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone |
| Anwendung: | USP14 / UCHL5 inhibitor |
| CAS | 1009817-63-3 |
| MW: | 419.4 D |
ab 50,00 €