Zu "K11787" wurden 20 Artikel gefunden!
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Lometrexol disodium
Artikelnummer: TGM-T63240-25mg
Description: Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer...
| Anwendung: | Targets GART |
| CAS | 120408-07-3 |
| MW: | 487.424 D |
ab 2.257,00 €
Pelitrexol
Artikelnummer: TGM-T14147-100mg
Description: Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor. Target: DHFR. Smiles: Cc1cc(sc1CC[C@@H]1CNc2nc(N)[nH]c(=O)c2C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O. References: Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell...
| Schlagworte: | AG 2037 |
| Anwendung: | Targets GART |
| CAS | 446022-33-9 |
| MW: | 463.51 D |
ab 510,00 €
Trifunctional purine biosynthetic protein adenosine-3...
Artikelnummer: CSB-EP324325HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 111-318aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: KEFMDRHGIP TAQWKAFTKP EEACSFILSA DFPALVVKAS GLAAGKGVIV AKSKEEACKA VQEIMQEKAF GAAGETIVIE ELLDGEEVSC LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP QVSNDLLLKI...
| Schlagworte: | PGFT, GARS, GART, AIRS, EC=2.1.2.2, EC=6.3.3.1, EC=6.3.4.13, AIR synthase, GAR transformylase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 26.5 kD |
ab 283,00 €
Azaserine
Artikelnummer: Cay14834-10
Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces that functions as a glutamine analog. At 25 µM, it inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase and glucosamine-6-phosphate isomerase. Azaserine...
| Schlagworte: | CI-337, CN 15757, NSC 742, O-Diazoacetyl-L-serine, O-(2-diazoacetyl)-L-serine |
| Anwendung: | Tumor-inhibiting antibiotic, glutamine analog |
| CAS | 115-02-6 |
| MW: | 173.1 D |
ab 50,00 €
Pemetrexed (sodium salt hydrate)
Artikelnummer: Cay14269-5
Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased...
| Schlagworte: | N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt,... |
| Anwendung: | Antifolate |
| CAS | 357166-29-1 |
| MW: | 597.5 D |
ab 82,00 €
Lometrexol (hydrate)
Artikelnummer: Cay18049-1
Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting...
| Schlagworte: | (6R)-Dideazatetrahydrofolate, DDATHF,... |
| Anwendung: | GART inhibitor |
| MW: | 443.5 D |
ab 130,00 €
Anti-GART
Artikelnummer: A304-311A
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates [taken from NCBI Entrez Gene (Gene ID: 2618)].
| Schlagworte: | Anti-AIRS, Anti-GARS, Anti-GART, Anti-PGFT, EC=2.1.2.2, EC=6.3.3.1, EC=6.3.4.13, Anti-AIR synthase, Anti-GAR... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Anti-GART
Artikelnummer: A304-312A
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates [taken from NCBI Entrez Gene (Gene ID: 2618)].
| Schlagworte: | Anti-AIRS, Anti-GARS, Anti-GART, Anti-PGFT, EC=2.1.2.2, EC=6.3.3.1, EC=6.3.4.13, Anti-AIR synthase, Anti-GAR... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Pemetrexed Disodium
Artikelnummer: LKT-P1849.10
Thymidylate synthase inhibitor, potential SHMT, DNFR, GARFT inhibitor.
| Anwendung: | Glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, thymidylate synthase inhibitor |
| CAS | 150399-23-8 |
| MW: | 471.37 D |
ab 90,00 €
Anti-GART
Artikelnummer: E-AB-62752.120
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative...
| Schlagworte: | Anti-GART, Anti-AIRS, Anti-PGFT, Anti-GARS, EC=2.1.2.2, EC=6.3.3.1, EC=6.3.4.13, Anti-AIR synthase, Anti-GAR... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 198,00 €
-30 %
Rabattaktion
Anti-GART
Artikelnummer: ARG58720.100
| Schlagworte: | Anti-GARS, Anti-AIRS, Anti-GART, Anti-PGFT, EC=6.3.3.1, EC=2.1.2.2, EC=6.3.4.13, Anti-AIR synthase, Anti-GAR... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €
436,80 €
Anti-GART
Artikelnummer: E-AB-17989.120
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative...
| Schlagworte: | Anti-GART, Anti-PGFT, Anti-GARS, Anti-AIRS, EC=2.1.2.2, EC=6.3.3.1, EC=6.3.4.13, Anti-AIR synthase, Anti-GAR... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 71,00 €