Zu "K11723" wurden 38 Artikel gefunden!
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BI-7273
Artikelnummer: TGM-T6783-10mg
Description: BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell. Target: Epigenetic Reader Domain. Smiles: COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12. References: Martin LJ, et al. J Med Chem. 2016, 59(10):4462-4475.
| Anwendung: | Cell-permeable BRD9 bromodomain inhibitor |
| CAS | 1883429-21-7 |
| MW: | 353.41 D |
ab 37,00 €
TP-472
Artikelnummer: TGM-T13190-1mg
Description: TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM). Target: Epigenetic Reader Domain. Smiles: CC(=O)c1cc(-c2cc(ccc2C)C(=O)NC2CC2)c2ncccn12. References: Moustakim M, et al. Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7,7(12):2246-2264.
| Anwendung: | BRD9/7 probe |
| CAS | 2079895-62-6 |
| MW: | 333.38 D |
ab 106,00 €
LP99
Artikelnummer: TGM-T15784-100mg
Description: LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). Target: Epigenetic Reader Domain. Smiles:...
| Anwendung: | BRD7/9 bromodomain inhibitor |
| CAS | 1808951-93-0 |
| MW: | 516.05 D |
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Anti-BRD7
Artikelnummer: A302-304A
Protein function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated...
| Schlagworte: | Anti-BRD7, Anti-BP75, Anti-Protein CELTIX-1, Anti-75 kDa bromodomain protein, Anti-Bromodomain-containing protein 7 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
LP99
Artikelnummer: Cay17661-5
LP99 is a potent inhibitor of the bromodomain containing proteins BRD7 and BRD9 that binds with Kd values of 99 and 909 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRD7/9 over a panel of 48 BRDs at concentrations up to 10 µM determined using differential scanning...
| Schlagworte: | N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfo... |
| Anwendung: | BRD7/9 bromodomain inhibitor |
| CAS | 1808951-93-0 |
| MW: | 516.1 D |
ab 67,00 €
I-BRD9
Artikelnummer: Cay17749-1
BRD9 contains a single bromodomain and has five isoforms that are produced by alternative splicing. It is thought to function in chromatin remodeling as part of the SWI/SNF complex. I-BRD9 is a BRD9 bromodomain inhibitor with a pIC50 value of 7.3 and a pKd value of 8.7. It displays 700-fold greater selectivity over...
| Schlagworte: | 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-thieno[3,2-c]pyridine... |
| Anwendung: | BRD9 bromodomain inhibitor |
| CAS | 1714146-59-4 |
| MW: | 497.6 D |
ab 100,00 €
BI-7273
Artikelnummer: Cay20311-1
BI-7273 is a potent BRD9 bromodomain inhibitor (Kd = 15.4 nM, IC50 = 19 nM) that less effectively inhibits the functionally and structurally related BRD7 bromodomain (IC50 = 117 nM). It is without effect against the bromodomains of BRD2 and BRD4, as well as a panel of kinases. BI-7273 inhibits the growth of EOL-1...
| Schlagworte: | 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one |
| Anwendung: | Cell-permeable BRD9 bromodomain inhibitor |
| CAS | 1883429-21-7 |
| MW: | 353.4 D |
ab 52,00 €
MZ1
Artikelnummer: Cay21622-500
MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1...
| Schlagworte: | (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3... |
| Anwendung: | BRD4 degradation promotor |
| CAS | 1797406-69-9 |
| MW: | 1002.6 D |
ab 66,00 €
TP-472
Artikelnummer: Cay20030-1
TP-472 is an inhibitor of bromodomain BRD9 (Kd = 33 nM, EC50 = 320 nM in a NanoBRET assay). It has >30-fold selectivity over all other bromodomain family members with the exception of the highly homologous BRD7 bromodomain (Kd = 340 nM in an isothermal titration calorimetry (ITC) assay). See the Structural Genomic...
| Schlagworte: | 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-benzamide |
| Anwendung: | BRD9/7 probe |
| CAS | 2079895-62-6 |
| MW: | 333.4 D |
ab 44,00 €
BI-9564
Artikelnummer: Cay17897-1
BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM, IC50s = 75 nM and 3.4 µM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 µM and 1 µM, respectively. It does not bind to other bromodomain-containing...
| Schlagworte: | 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one |
| Anwendung: | BRD9 & BRD7 bromodomain inhibitor |
| CAS | 1883429-22-8 |
| MW: | 353.4 D |
ab 44,00 €
Anti-BRD7 (IHC)
Artikelnummer: IHC-00664
Protein function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated...
| Schlagworte: | Anti-BRD7, Anti-BP75, Anti-Protein CELTIX-1, Anti-75 kDa bromodomain protein, Anti-Bromodomain-containing protein 7 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-BRD7
Artikelnummer: E-AB-62431.120
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence...
| Schlagworte: | Anti-BRD7, Anti-BP75, Anti-Protein CELTIX-1, Anti-75 kDa bromodomain protein, Anti-Bromodomain-containing protein 7, BRD7... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 268,00 €