Zu "K11721" wurden 57 Artikel gefunden!
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GSK778
Artikelnummer: Cay41280-1
GSK778 is a bromodomain 1 (BD1) inhibitor. It selectively inhibits BD1 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and bromodomain testis-specific protein (BRDT, IC50s = 79.43, 39.81, 39.81, and 158.49 nM, respectively, in time-resolved FRET assays) over BD2 in BRD2, BRD3, BRD4, and BRDT (IC50s = 3,162,...
| Schlagworte: | iBET-BD1, iBET-Bromodomain 1,... |
| Anwendung: | BD1 inhibitor |
| CAS | 2451862-42-1 |
| MW: | 511.6 D |
ab 78,00 €
Anti-BRD3
Artikelnummer: A302-368A
Protein function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1...
| Schlagworte: | Anti-BRD3, Anti-KIAA0043, Anti-RING3-like protein, Anti-Bromodomain-containing protein 3 |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
GSK046
Artikelnummer: TGM-T8932-100mg
Description: GSK046 (iBET-BD2) is a potent, selective, and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50 values of 264 nM [BRD2 BD2], 98 nM [BRD3 BD2], 49 nM [BRD4 BD2], and 214 nM [BRDT BD2], respectively. It exhibits immunomodulatory activity. Target: Epigenetic Reader Domain. Smiles:...
| Schlagworte: | iBET-BD2 |
| Anwendung: | BD2 bromodomain inhibitor |
| CAS | 2474876-09-8 |
| MW: | 414.47 D |
ab 114,00 €
GSK620
Artikelnummer: TGM-T9020-100mg
Description: GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620...
| Anwendung: | BET BD2 inhibitor |
| CAS | 2088410-46-0 |
| MW: | 325.36 D |
ab 34,00 €
Anti-BRD3
Artikelnummer: CSB-PA001045.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-BRD3, Anti-KIAA0043, Anti-RING3-like protein, Anti-Bromodomain-containing protein 3, BRD 3 antibody, Brd3 antibody,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 126,00 €
(+)-JQ1 Bromodomain Inhibitor
Artikelnummer: BPS-27401
(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains. (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.
| Schlagworte: | BET inhibitor, Bromodomain inhibitor, |
| Anwendung: | BRD inhibitor |
| MW: | 456.99 D |
195,00 €
Anti-BRD3
Artikelnummer: A302-367A
Protein function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1...
| Schlagworte: | Anti-BRD3, Anti-KIAA0043, Anti-RING3-like protein, Anti-Bromodomain-containing protein 3 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
GSK620
Artikelnummer: Cay36139-10
GSK620 is a bromodomain and extra terminal domain family of proteins (BET) bromodomain 2 (BD2) inhibitor (IC50s = 316.2, 79.4, 79.4, and 199.5 nM for BRD2, BRD3, BRD4, and BRDT BD2, respectively). It is selective for BD2 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and BRDT over BD1 in the same BRDs...
| Schlagworte: | N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-3,5-pyridinedicarboxamide |
| Anwendung: | BET BD2 inhibitor |
| CAS | 2088410-46-0 |
| MW: | 325.4 D |
ab 75,00 €
I-BET151
Artikelnummer: LKT-I0516.25
I-BET-151 is a BET bromodomain (BRD) inhibitor that inhibits BRD2, BRD3, and BRD4. I-BET-151 exhibits anticancer chemotherapeutic and anti-inflammatory activities. In vitro and in vivo, this compound induces apoptosis and inhibits cellular proliferation in various cancer models. I-BET-151 inhibits recruitment of the...
| Schlagworte: | GSK-1210151A, GSK1210151A |
| Anwendung: | pan-BET family inhibitor |
| CAS | 1300031-49-5 |
| MW: | 415.44 D |
ab 248,00 €
iBET-BD2
Artikelnummer: Cay31766-1
iBET-BD2 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2). It inhibits BD2 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and BRDT (IC50s = 264, 98, 49, and 214 nM, respectively) and is selective for BD2 over BD1 (IC50s = 10.96, 36.31, 70.55, and >50.11...
| Schlagworte: | GSK046, 4-acetamido-3-fluoro-N-((1r,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide |
| Anwendung: | BD2 bromodomain inhibitor |
| CAS | 2474876-09-8 |
| MW: | 414.5 D |
ab 44,00 €
BRD3 (29-145), His-tag, human recombinant protein
Artikelnummer: BPS-31030
Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 29-145 (GenBank Accession No. NM_007371) with N-terminal HIS tag, MW = 14.9 kDa, expressed in an E. coli expression system.
| Schlagworte: | BRD3, KIAA0043, RING3-like protein, Bromodomain-containing protein 3, |
| Anwendung: | Binding assays, inhibitor screening, selectivity profiling |
| MW: | 14.9 kD |
461,00 €
BRD3 (306-417), His-tag, human recombinant protein
Artikelnummer: BPS-31031
Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 306-417 (GenBank Accession No. NM_007371) with N-terminal HIS tag, MW = 14.1 kDa, expressed in an E. coli expression system.
| Schlagworte: | BRD3, KIAA0043, RING3-like protein, Bromodomain-containing protein 3, |
| Anwendung: | Binding assays, inhibitor screening, selectivity profiling |
| MW: | 14.1 kD |
461,00 €