Zu "K11713" wurden 8 Artikel gefunden!
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GGTI-286
Artikelnummer: TGM-T62379-100mg
Description: GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 µM). GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 µM) more potently than H-Ras farnesylation (IC50>30 µM). Ras4B stimulation (IC50: 1 µM). Target: Others. Smiles:...
| Anwendung: | Cell-permeable, potent, selective GGTase I inhibitor |
| CAS | 171744-11-9 |
| MW: | 429.58 D |
ab 2.100,00 €
GGTI 2418
Artikelnummer: Cay28714-1
GGTI 2418 is an inhibitor of geranylgeranyl transferase type I (GGTase I, IC50 = 9.5 nM). It is selective for GGTase I over farnysltransferase (FTase, IC50 = 53,000 nM). GGTI 2418 (100 mg/kg) reduces tumor growth in an MDA-MB-231 breast cancer mouse xenograft model.Formal Name:...
| Schlagworte: | N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-L-leucine |
| Anwendung: | GGTase I inhibitor |
| CAS | 501010-06-6 |
| MW: | 441.5 D |
ab 96,00 €
GGTI 2133 (trifluoroacetate salt)
Artikelnummer: Cay23418-1
GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I, IC50 = 38 nM). It is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). In vitro, it inhibits geranylgeranylation of RAP1A (IC50 = 10 µM) without inhibiting farnesylation of H-Ras (IC50 = >30 µM). It also...
| Schlagworte: | N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, 2,2,2-trifluoroacetate salt |
| Anwendung: | Geranylgeranyl transferase type I (GGTase I) inhibitor |
| CAS | 1217480-14-2 |
| MW: | 456.5 D |
ab 139,00 €
L-778,123
Artikelnummer: Cay32504-5
L-778,123 is a dual inhibitor of farnesyl transferase (FTase, IC50 = 2 nM) and geranylgeranyl transferase type I (GGTase I, IC50 = 98 nM). It inhibits prenylation of the FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively). L-778,123 (1-300 µM) also...
| Schlagworte: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-benzonitrile |
| Anwendung: | Dual FTase / GGTase I inhibitor |
| CAS | 183499-57-2 |
| MW: | 405.9 D |
ab 109,00 €
GGTI 2133 TFA
Artikelnummer: TGM-T85180-10mg
Description: GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I, IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the...
| Anwendung: | Geranylgeranyl transferase type I (GGTase I) inhibitor |
| CAS | 1217480-14-2 |
| MW: | 570.569 D |
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PGGT1B, Human protein geranylgeranyltransferase type I,...
Artikelnummer: VHPS-6822
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | PGGT1B, EC=2.5.1.59, GGTase-I-beta, Geranylgeranyl transferase type-1 subunit beta, Geranylgeranyl transferase type I... |
| Anwendung: | RNA quantification |
43,00 €
Pggt1B, Mouse protein geranylgeranyltransferase type I,...
Artikelnummer: VMPS-4696
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Pggt1b, EC=2.5.1.59, GGTase-I-beta, Geranylgeranyl transferase type-1 subunit beta, Geranylgeranyl transferase type I... |
| Anwendung: | RNA quantification |
43,00 €
Pggt1B, Rat protein geranylgeranyltransferase type I,...
Artikelnummer: VRPS-4467
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Pggt1b, EC=2.5.1.59, GGTase-I-beta, Geranylgeranyl transferase type-1 subunit beta, Geranylgeranyl transferase type I... |
| Anwendung: | RNA quantification |
52,00 €