Zu "K11481" wurden 148 Artikel gefunden!
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LY3295668
Artikelnummer: Cay27914-1
LY3295668 is an inhibitor of Aurora A kinase (IC50 = 2 phase in HeLa cells (IC50 = 108 nM). In vivo, LY3295668 (40 mg/kg per day) decreases tumor volume in a patient-derived xenograft (PDX) mouse model of small cell lung cancer.Formal Name:...
| Schlagworte: | AK-01,... |
| Anwendung: | Aurora A kinase inhibitor |
| CAS | 1919888-06-4 |
| MW: | 490 D |
ab 103,00 €
Alisertib sodium hydrate
Artikelnummer: TGM-T71232-100mg
Description: Alisertib sodium hydrate is a salt of Alisertib --- an inhibitor of Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and...
| Anwendung: | Targets aurora kinase A [EC:2.7.11.1] (AURKA) |
| CAS | 1208255-63-3 |
| MW: | 558.93 D |
ab 1.638,00 €
Tripolin A
Artikelnummer: TGM-T8537-25mg
Description: Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 µM and 7 µM, respectively). Target: Aurora Kinase. Smiles: C(=C/1\C=2C(NC1=O)=CC=CC2)\C3=C(O)C=CC(O)=C3. References: Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule...
| Anwendung: | Aurora A kinase inhibitor |
| CAS | 1148118-92-6 |
| MW: | 253.25 D |
800,00 €
Aurora kinase inhibitor-2
Artikelnummer: TGM-T9040-100mg
Description: Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). Target: Aurora Kinase. Smiles: COc1cc2ncnc(Nc3ccc(NC(=O)c4ccccc4)cc3)c2cc1OC. References: Heron N M , Anderson M , Blowers D P , et al. SAR and inhibitor complex structure...
| Schlagworte: | Aurora Kinase Inhibitor II, IUN-70219 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 331770-21-9 |
| MW: | 400.43 D |
ab 98,00 €
SNS-314 Mesylate
Artikelnummer: TGM-T2617-100mg
Description: SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. Target: Aurora Kinase. Smiles: CS(O)(=O)=O.Clc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1. References: Oslob JD, et al. Bioorg Med Chem Lett,...
| Schlagworte: | SNS-314 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 1146618-41-8 |
| MW: | 527.04 D |
ab 33,00 €
CYC-116
Artikelnummer: TGM-T6458-100mg
Description: CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3alpha/beta, CK2, Plk1 and SAPK2A. Phase 1. Target: FLT, CDK, Aurora Kinase, VEGFR, S6 Kinase....
| Anwendung: | Aurora / VEGFR2 inhibitor |
| CAS | 693228-63-6 |
| MW: | 368.46 D |
ab 33,00 €
AKI603
Artikelnummer: TGM-T64338-100mg
Description: AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells[1][2]. Target: Aurora Kinase. Smiles:...
| Schlagworte: | AKI-603, AKI 603 |
| Anwendung: | Aurora A kinase inhibitor |
| CAS | 1432515-73-5 |
| MW: | 409.45 D |
ab 98,00 €
Aurora kinase inhibitor-8
Artikelnummer: TGM-T63773-25mg
Description: Aurora kinase inhibitor-8 (highly selective) inhibits Aurora kinase. Target: Others. Smiles: CCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2ncc3N(C)C(=O)c4cc(C)ccc4N(C)c3n2)cc1
| Anwendung: | Aurora kinase inhibitor |
| CAS | 2133001-88-2 |
| MW: | 535.6 D |
ab 1.619,00 €
PHA-680632
Artikelnummer: TGM-T6338-100mg
Description: PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. Target: FGFR, Aurora Kinase, PLK. Smiles:...
| Schlagworte: | PHA 680632, PHA680632 |
| Anwendung: | Aurora A/B/C kinase inhibitor |
| CAS | 398493-79-3 |
| MW: | 501.62 D |
ab 39,00 €
Aurora A inhibitor 1
Artikelnummer: TGM-T63436-100mg
Description: Aurora A inhibitor 1 is a potent and selective inhibitor of Aurora A, a protein associated with cancers of multiple histological origins that may exhibit oncogenic activity when overexpressed. Aurora A inhibitor 1 exhibits potential for studies related to Aurora A-mediated cancer diseases. Target:...
| Anwendung: | Aurora A inhibitor |
| CAS | 2677799-04-9 |
| MW: | 503.97 D |
ab 2.100,00 €
TCS7010
Artikelnummer: TGM-T6767-100mg
Description: TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Target: Apoptosis, Aurora Kinase. Smiles: CCN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc(F)c(Nc3ccc(cc3)C(=O)Nc3ccccc3Cl)n2)cc1....
| Schlagworte: | Aurora A Inhibitor I |
| Anwendung: | AURKA inhibitor |
| CAS | 1158838-45-9 |
| MW: | 588.07 D |
ab 31,00 €
JNJ-7706621
Artikelnummer: TGM-T6126-100mg
Description: JNJ-7706621 is a potent aurora kinase inhibitor that also inhibits CDK1 and CDK2. Target: Aurora Kinase, CDK, Apoptosis. Smiles: Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F. References: Emanuel S, et al. Cancer Res, 2005, 65(19), 9038-9046.
| Schlagworte: | JNJ 7706621 |
| Anwendung: | Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Aurora A/B inhibitor |
| CAS | 443797-96-4 |
| MW: | 394.36 D |
ab 43,00 €