Zu "K11450" wurden 82 Artikel gefunden!
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Anti-KDM1A
Artikelnummer: ABS-KC-2567.100
Protein function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the...
| Schlagworte: | Anti-Lysine-specific histone demethylase 1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Flavin-containing amine oxidase... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-KDM1A
Artikelnummer: ABS-KC-2783.100
Protein function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the...
| Schlagworte: | Anti-Lysine-specific histone demethylase 1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Flavin-containing amine oxidase... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-KDM1A
Artikelnummer: ABS-OC-271.100
Protein function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the...
| Schlagworte: | Anti-Lysine-specific histone demethylase 1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Flavin-containing amine oxidase... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-KDM1A
Artikelnummer: ABS-KC-6424.100
Protein function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the...
| Schlagworte: | Anti-Lysine-specific histone demethylase 1A, Anti-BRAF35-HDAC complex protein BHC110, Anti-Flavin-containing amine oxidase... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, monkey |
ab 232,00 €
Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
Artikelnummer: TGM-T36627-10mg
Description: Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 µM.1It increases the level of H3K4 methylation, including...
| Anwendung: | Lysine-specific Demethylase inhibitor |
| CAS | 1234494-75-7 |
| MW: | 474.34 D |
ab 52,00 €
GSK2879552
Artikelnummer: TGM-T3677-2mg
Description: GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity. Target: Histone Demethylase. Smiles: OC(=O)c1ccc(CN2CCC(CN[C@@H]3C[C@H]3c3ccccc3)CC2)cc1. References: Mohammad HP, et al....
| Schlagworte: | GSK2879552 2HCl |
| Anwendung: | LSD1 inhibitor |
| CAS | 1401966-69-5 |
| MW: | 364.48 D |
108,00 €
Seclidemstat
Artikelnummer: TGM-T4527-100mg
Description: Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM. Target: Histone Demethylase. Smiles: CN1CCN(CC1)S(=O)(=O)c1cccc(c1)C(=O)N\N=C(/C)c1cc(Cl)ccc1O. References: SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLAS EINHIBITOR S. WO/2017/004519 A1
| Schlagworte: | SP-2577 |
| Anwendung: | Targets KDM1A (AOF2, LSD1) |
| CAS | 1423715-37-0 |
| MW: | 450.94 D |
ab 42,00 €
ORY1001
Artikelnummer: TGM-T6922-100mg
Description: ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM. Target: Histone Demethylase. Smiles: Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1. References: Maes T, et al. J Clin...
| Schlagworte: | RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001 |
| Anwendung: | LSD1 inhibitor |
| CAS | 1431326-61-2 |
| MW: | 303.27 D |
ab 55,00 €
Bomedemstat ditosylate
Artikelnummer: TGM-T70008-100mg
Description: Bomedemstat ditosylate (IMG-7289 ditosylate) is an orally active lysine-specific demethylase 1 (LSD1) inhibitor with antitumor activity that potentiates the response to PD-1 inhibition in a homozygous model of SCLC, inhibits cancer cell proliferation, and induces apoptosis. Bomedemstat ditosylate can be...
| Schlagworte: | MK-3543 ditosylate, IMG-7289 ditosylate |
| Anwendung: | Targets KDM1A (AOF2, LSD1) |
| CAS | 1990504-72-7 |
| MW: | 864.02 D |
ab 117,00 €
Bomedemstat
Artikelnummer: TGM-T9634-25mg
Description: Bomedemstat (IMG-7289) is an orally active, irreversible inhibitor of lysine-specific demethylase 1 (LSD1) that exhibits antineoplastic activities in mouse models of myeloproliferative neoplasms (MPNs), and can be used for research on acute myelogenous leukemia (AML) and myelofibrosis (MF) [1]. Target:...
| Anwendung: | Targets KDM1A (AOF2, LSD1) |
| CAS | 1990504-34-1 |
| MW: | 519.61 D |
ab 2.167,00 €
LSD1 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-03056-50ug
Description: LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0 through a FAD-dependent oxidative reaction. When forming a...
| Schlagworte: | KDM1, AOF2, LSD1, BHC110, lysine (K)-specific demethylase 1A |
| MW: | 103.3 kD |
599,00 €
OG-L002
Artikelnummer: TGM-T6073-100mg
Description: OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively. Target: HSV, Monoamine Oxidase, Histone Demethylase. Smiles: N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(O)c1. References: MBio. 2013, 4(1), e00558-12.
| Anwendung: | LSD1 inhibitor |
| CAS | 1357302-64-7 |
| MW: | 225.29 D |
ab 37,00 €