Zu "K11448" wurden 32 Artikel gefunden!
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GSK-J4 Hydrochloride
Artikelnummer: TGM-T4383-100mg
Description: GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 µM in vitro. Target: Histone Demethylase. Smiles: Cl.CCOC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1....
| Schlagworte: | GSK J4 HCl, GSK J4 HCl (1373423-53-0 free base) |
| Anwendung: | Histone demethylase inhibitor |
| CAS | 1797983-09-5 |
| MW: | 453.97 D |
ab 34,00 €
GSK-J1 sodium salt
Artikelnummer: TGM-T71916-10mg
Description: GSK-J1 sodium salt is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX. Target: Others. Smiles: [Na+].[O-]C(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
| Anwendung: | JMJD3 inhibitor |
| CAS | 1797832-71-3 |
| MW: | 411.4408 D |
ab 77,00 €
IOX1
Artikelnummer: TGM-T6545-100mg
Description: IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively. Target: Histone Demethylase. Smiles: OC(=O)c1ccc(O)c2ncccc12. References: Schiller R, et al. ChemMedChem. 2014, 9(3), 566-571.
| Anwendung: | JMJD demethylase inhibitor |
| CAS | 5852-78-8 |
| MW: | 189.17 D |
ab 38,00 €
Lysine-specific demethylase 6B (KDM6B), partial, human,...
Artikelnummer: CSB-EP517674HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1530-1682aa. Protein Length: Partial of Isoform 1. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: PDLFKMIKFC LLQSMKHCQV QRESLVRAGK KIAYQGRVKD EPAYYCNECD VEVFNILFVT SENGSRNTYL VHCEGCARRR SAGLQGVVVL EQYRTEELAQ AYDAFTLVRA RRARGQRRRA...
| Schlagworte: | JMJD3, KDM6B, Lysine demethylase 6B, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 23.9 kD |
ab 283,00 €
Lysine-specific demethylase 6B (KDM6B), partial, human,...
Artikelnummer: CSB-EP517674HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1176-1505aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: LPREKLNPPT PSIYLESKRD AFSPVLLQFC TDPRNPITVI RGLAGSLRLN LGLFSTKTLV EASGEHTVEV RTQVQQPSDE NWDLTGTRQI WPCESSRSHT TIAKYAQYQA SSFQESLQEE KESEDEESEE...
| Schlagworte: | JMJD3, KDM6B, Lysine demethylase 6B, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 41.5 kD |
ab 283,00 €
Anti-KDM6B
Artikelnummer: CSB-PA174245.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KDM6B. Antigen Species: Human
| Schlagworte: | Anti-JMJD3, Anti-KDM6B, Anti-Lysine demethylase 6B, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 163,00 €
GSK-J4 (hydrochloride)
Artikelnummer: Cay12073-5
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 (hydrochloride) is an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cay-12054) with an...
| Schlagworte: | N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, ethyl ester, monohydrochloride |
| Anwendung: | Histone demethylase inhibitor |
| CAS | 1797983-09-5 |
| MW: | 454 D |
ab 77,00 €
JIB-04
Artikelnummer: Cay15338-5
JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine...
| Schlagworte: | JHDM Inhibitor VII, NSC 693627, phenyl-2-pyridinyl-methanone, (E,E)-2-(5-chloro-2-pyridinyl)hydrazone |
| Anwendung: | Jumonji histone demethylase inhibitor |
| CAS | 199596-05-9 |
| MW: | 308.8 D |
ab 109,00 €
JMJD3, active human, C-terminal DDDK (Flag) Tag
Artikelnummer: BPS-50115
Human JMJD3/KDM6B histone demethylase (a.a. 1000-end) expressed in Sf9 cells. Methylation of Lys27 of histone H3 (H3K27) is a silencing mark associated with imprinting and X chromosome activation. JMJD3 is a histone demethylase that demethylates di- and trimethyl-lysine 27 on histone H3, JMJD3 also plays important...
| Schlagworte: | KDM6B, JMJD3, Lysine demethylase 6B, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji... |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
| MW: | 71 kD |
701,00 €
GSK-J1 (sodium salt)
Artikelnummer: Cay12054-5
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s = 18 and 56 µM, respectively as measured by mass...
| Schlagworte: | N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, monosodium salt |
| Anwendung: | JMJD3 inhibitor |
| CAS | 1797832-71-3 |
| MW: | 411.4 D |
ab 43,00 €
Anti-Kdm6b
Artikelnummer: NSJ-F52856-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene...
| Schlagworte: | Anti-Jmjd3, Anti-Kdm6b, EC=1.14.11.-, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing protein 3,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 326,00 €
JMJD3 chemiluminescent assay kit
Artikelnummer: BPS-50406
The JMJD3 Chemiluminescent Assay Kit is designed to measure JMJD3 activity for screening and profiling applications. JMJD3 is a JmjC-domain protein that exhibits demethylation activity toward di- and trimethyl-lysine 27 (H3K27me2/3) on histone H3. The JMJD3 Assay Kit comes in a convenient format, with 8-well strips...
| Schlagworte: | JMJD3, KDM6B, |
| Anwendung: | Enzyme kinetics, HTS |
1.065,00 €