Zu "K11446" wurden 95 Artikel gefunden!
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JQKD82 (hydrochloride)
Artikelnummer: Cay41542-1
JQKD82 is a prodrug form of KDM5-C49, an inhibitor of Jumonji AT-rich interactive domain 1A (JARID1A), also known as lysine-specific demethylase 5A (KDM5A). It increases the levels of trimethylated lysine 4 on histone 3 (H3K4me3) in MOLP-8 and MM.1S multiple myeloma cells when used at concentrations of 0.3 and 1 µM....
| Schlagworte: | JADA82, PCK82, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-4-pyridinecarboxylic acid,... |
| Anwendung: | KDM5-C49 (KDM5A inhibitor) prodrug |
| CAS | 2863676-87-1 |
| MW: | 610 D |
ab 90,00 €
JIB-04
Artikelnummer: TGM-T1868-100mg
Description: JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor. Target: Apoptosis, Histone Methyltransferase, Histone Demethylase. Smiles: Clc1ccc(N\N=C(/c2ccccc2)c2ccccn2)nc1. References: Wang L, et al. Nat Commun. 2013, 4, 2035.
| Schlagworte: | NSC 693627, JIB 04 |
| Anwendung: | Jumonji histone demethylase inhibitor |
| CAS | 199596-05-9 |
| MW: | 308.76 D |
ab 31,00 €
PBIT
Artikelnummer: TGM-T16435-100mg
Description: PBIT inhibits JARID1B histone demethylase (IC50 of about 3 µM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 µM and 4.9 µM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . Target: Histone Methyltransferase, Histone Demethylase. Smiles:...
| Anwendung: | JARID1B inhibitor |
| CAS | 2514-30-9 |
| MW: | 241.31 D |
ab 34,00 €
KDM5-C70
Artikelnummer: TGM-T15648-100mg
Description: KDM5-C70 is an ethyl ester derivative of KDM5-C49 and functions as an effective, cell-permeable, pan-KDM5 histone demethylase inhibitor. It exhibits an antiproliferative effect in myeloma cells and induces a genome-wide elevation of H3K4me3 levels. Target: Histone Demethylase. Smiles:...
| Anwendung: | KDM5B (JARID1B) inhibitor |
| CAS | 1596348-32-1 |
| MW: | 336.43 D |
ab 37,00 €
CPI-455
Artikelnummer: TGM-T3552-100mg
Description: CPI-455 is a specific KDM5 inhibitor. Target: Histone Demethylase. Smiles: CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1. References: Vinogradova M, et al. Nat Chem Biol. 2016, 12(7):531-8.
| Schlagworte: | CPI-455 HCl |
| Anwendung: | KDM5A/B/C histone demethylase inhibitor |
| CAS | 1628208-23-0 |
| MW: | 278.31 D |
ab 37,00 €
Anti-KDM5B
Artikelnummer: CSB-PA176057.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KDM5B. Antigen Species: Human
| Schlagworte: | Anti-CT31, Anti-KDM5B, Anti-PLU-1, Anti-JARID1B, Anti-RBP2-H1, Anti-Cancer/testis antigen 31, Anti-Histone demethylase... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 163,00 €
Anti-KDM5B
Artikelnummer: CSB-PA295068.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KDM5B. Antigen Species: Human
| Schlagworte: | Anti-CT31, Anti-KDM5B, Anti-PLU-1, Anti-JARID1B, Anti-RBP2-H1, Anti-Cancer/testis antigen 31, Anti-Histone demethylase... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 163,00 €
Anti-KDM5A
Artikelnummer: CSB-PA779455.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KDM5A. Antigen Species: Human
| Schlagworte: | Anti-RBBP-2, Anti-JARID1A, Anti-Histone demethylase JARID1A, Anti-Lysine-specific demethylase 5A,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 163,00 €
Anti-KDM5C
Artikelnummer: CSB-PA798835.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KDM5C. Antigen Species: Human
| Schlagworte: | Anti-Protein SmcX, Anti-Protein Xe169, Anti-Histone demethylase JARID1C, Anti-Lysine-specific demethylase 5C,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 163,00 €
Lysine-specific demethylase 5A (KDM5A), human, recombinant
Artikelnummer: CSB-EP012141HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 437-603aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: EYALSGWNLN NMPVLEQSVL AHINVDISGM KVPWLYVGMC FSSFCWHIED HWSYSINYLH WGEPKTWYGV PSHAAEQLEE VMRELAPELF ESQPDLLHQL VTIMNPNVLM...
| Schlagworte: | RBBP-2, JARID1A, Histone demethylase JARID1A, Lysine-specific demethylase 5A, Retinoblastoma-binding protein 2,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 35.3 kD |
ab 213,00 €
Lysine-specific demethylase 5A (KDM5A), partial, human,...
Artikelnummer: CSB-YP012141HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 437-603aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: EYALSGWNLN NMPVLEQSVL AHINVDISGM KVPWLYVGMC FSSFCWHIED HWSYSINYLH WGEPKTWYGV PSHAAEQLEE VMRELAPELF ESQPDLLHQL VTIMNPNVLM EHGVPVYRTN QCAGEFVVTF PRAYHSGFNQ...
| Schlagworte: | RBBP-2, JARID1A, Histone demethylase JARID1A, Lysine-specific demethylase 5A, Retinoblastoma-binding protein 2,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 21.3 kD |
ab 235,00 €
Anti-JARID1C
Artikelnummer: A301-034A
Protein function: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'....
| Schlagworte: | Anti-KDM5C, Anti-DXS1272E, EC=1.14.11.-, Anti-Protein SmcX, Anti-Protein Xe169, Anti-Histone demethylase JARID1C,... |
| Anwendung: | WB, IP, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €