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Anti-PRMT6
Artikelnummer: ABS-KC-6070.100
Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially...
| Schlagworte: | Anti-Protein arginine N-methyltransferase 6, Anti-Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
EPZ020411
Artikelnummer: TGM-T4314-10mg
Description: EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). Target: Histone Methyltransferase. Smiles: CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@@H](C2)OCCC2CCOCC2)cc1. References: Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First...
| Schlagworte: | EPZ020411 2HCl |
| Anwendung: | Potent, selective PRMT6 inhibitor |
| CAS | 1700663-41-7 |
| MW: | 442.6 D |
ab 136,00 €
MS023
Artikelnummer: TGM-T6900-100mg
Description: MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 values of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. Target: Histone Methyltransferase. Smiles: CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN. References: Eram MS, et al. ACS Chem Biol....
| Anwendung: | Type I PRMT inhibitor |
| CAS | 1831110-54-3 |
| MW: | 287.4 D |
ab 34,00 €
SGC6870
Artikelnummer: TGM-T69580-25mg
Description: SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases. Target: Others. Smiles: C(=O)(N1[C@@H](C=2C(NC(=O)C1)=CC=C(C)C2)C3=CC(C)=CC(C)=C3)C=4SC(Br)=CC4
| Anwendung: | PRMT6 inhibitor |
| CAS | 2561471-27-8 |
| MW: | 469.39 D |
ab 547,00 €
GSK3368715 hydrochloride
Artikelnummer: TGM-T84982-10mg
Description: GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595...
| Schlagworte: | GSK715 hydrochloride |
| Anwendung: | Type I PRMT inhibitor |
| CAS | 2227587-25-7 |
| MW: | 403 D |
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PRMT6 Protein, Human, Recombinant (His & Flag)
Artikelnummer: TGM-TMPY-01383-50ug
Description: Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of...
| Schlagworte: | protein arginine methyltransferase 6, HRMT1L6 |
| MW: | 44.4 kD |
599,00 €
PRMT6, active human recombinant protein, N-terminal His-tag
Artikelnummer: BPS-51049
Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375(end), with N-terminal His-tag, MW=43 kDa, expressed in E. coli. Assay conditions: 50 µl reaction mix (20 mM phosphate buffer pH 7.4, 20 µM S-adenosylmethionine, and 1-5 ng methyl-transferase PRMT6) is added to microwells coated with histone substrate....
| Schlagworte: | PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, Histone-arginine N-methyltransferase PRMT6, Heterogeneous nuclear... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 43 kD |
498,00 €
Anti-PRMT6
Artikelnummer: A300-928A
Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays...
| Schlagworte: | Anti-PRMT6, Anti-HRMT1L6, Anti-Protein arginine N-methyltransferase 6, Anti-Histone-arginine N-methyltransferase PRMT6,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-PRMT6
Artikelnummer: A300-929A
Protein function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays...
| Schlagworte: | Anti-PRMT6, Anti-HRMT1L6, Anti-Protein arginine N-methyltransferase 6, Anti-Histone-arginine N-methyltransferase PRMT6,... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
GSK3368715 (hydrochloride)
Artikelnummer: Cay34886-1
GSK3368715 is an inhibitor of type I protein arginine methyltransferases (PRMTs, IC50s = 3.1, 162, 38, 4.7, and 39 nM for PRMT1, 3, 4, 6, and 8, respectively). It is selective for type I PRMTs over PRMT5, 7, and 9 (IC50s = >20,408, >40,000, and >15,000 nM, respectively), as well as 20 additional methyltransferases...
| Schlagworte: | N1-[[3-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl]methyl]-N1,N2-dimethyl-1,2-ethanediamine, monohydrochloride |
| Anwendung: | Type I PRMT inhibitor |
| CAS | 2227587-25-7 |
| MW: | 403 D |
ab 106,00 €
EPZ020411
Artikelnummer: Cay19160-1
EPZ020411 is an inhibitor of protein arginine methyltranferase 6 (PRMT6, IC50 = 10 nM) that less potently targets PRMT1 and PRMT8 (IC50s = 119 and 223 nM, respectively). It dose-dependently decreases methylation of the PRMT6 substrate H3R2 in A375 cells transiently expressing PRMT6 (IC50 = 0.637 µM). EPZ020411 shows...
| Schlagworte: | N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-1,2-... |
| Anwendung: | Potent, selective PRMT6 inhibitor |
| CAS | 1700663-41-7 |
| MW: | 442.6 D |
ab 65,00 €
MS049 (hydrochloride)
Artikelnummer: Cay18348-1
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases...
| Schlagworte: | N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride |
| Anwendung: | PRMT4 inhibitor, PRMT6 inhibitor |
| CAS | 2095432-59-8 |
| MW: | 321.3 D |
ab 61,00 €