Zu "K11430" wurden 135 Artikel gefunden!
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NEU
Anti-EZH2
Artikelnummer: ABS-KC-3192.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Schlagworte: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
NEU
Anti-EZH2
Artikelnummer: ABS-OC-533.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Schlagworte: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
GSK126
Artikelnummer: TGM-T2079-100mg
Description: GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM). Target: Histone Methyltransferase. Smiles: CC[C@H](C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Ott HM, et al. A687V EZH2 is a driver of histone H3 lysine 27 (H3K27)...
| Schlagworte: | GSK2816126A, EZH2 inhibitor |
| Anwendung: | Selective EZH2 methyltransferase inhibitor |
| CAS | 1346574-57-9 |
| MW: | 526.67 D |
ab 38,00 €
UNC1999
Artikelnummer: TGM-T3057-100mg
Description: UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). Target: Autophagy, Histone Methyltransferase. Smiles: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C. References: Konze KD, et al. ACS Chem. Biol. 2013, 8 (6),...
| Anwendung: | Cell-permeable EZH2 inhibitor |
| CAS | 1431612-23-5 |
| MW: | 569.74 D |
ab 31,00 €
ZLD1039
Artikelnummer: TGM-T29231-10mg
Description: ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 (Polycomb Repressive Complex 2) enzymatic activities, exhibiting IC50 values of 5.6,...
| Schlagworte: | ZLD 1039, ZLD-1039 |
| Anwendung: | EZH2 inhibitor |
| CAS | 1826865-46-6 |
| MW: | 612.8 D |
ab 31,00 €
Tulmimetostat
Artikelnummer: TGM-T40199-100mg
Description: Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor with antitumor activity, utilized in the study of ovarian cancer and advanced solid tumors. Target: Histone Methyltransferase. Smiles: CC1=C2C(O[C@@](C)(O2)[C@@]3(CC[C@H](CC3)N4CC(OC)C4)[H])=C(Cl)C=C1C(NCC5=C(SC)C=C(C)NC5=O)=O. References:...
| Schlagworte: | CPI-0209 |
| Anwendung: | Targets [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] (EZH2) |
| CAS | 2567686-02-4 |
| MW: | 562.12 D |
ab 31,00 €
CPI-1205
Artikelnummer: TGM-T8510-10mg
Description: CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 µM, EC50 : 0.032 µM) . Target: Histone Methyltransferase. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4. References: Vaswani RG, et al. Identification of...
| Schlagworte: | Lirametostat |
| Anwendung: | EZH2 inhibitor |
| CAS | 1621862-70-1 |
| MW: | 518.57 D |
ab 84,00 €
EPZ005687
Artikelnummer: TGM-T1905-100mg
Description: EPZ005687, a potent and selective inhibitor of EZH2. Target: Histone Methyltransferase. Smiles: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1. References: Knutson SK, et al. Nat Chem Biol, 2012, 8(11), 890-896.
| Anwendung: | Lysine methyltranferase EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.67 D |
ab 54,00 €
GSK503
Artikelnummer: TGM-T1775-100mg
Description: GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. Target: Histone Methyltransferase. Smiles: CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Béguelin W, et al. Cancer Cell. 2013, 23(5), 677-692
| Anwendung: | EZH2 inhibitor |
| CAS | 1346572-63-1 |
| MW: | 526.67 D |
ab 31,00 €
3-deazaneplanocin A HCl
Artikelnummer: TGM-T6360-100mg
Description: 3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor. Target: Others, Histone Methyltransferase. Smiles: Cl.Nc1nccc2n(cnc12)C1C=C(CO)C(O)C1O. References: Glazer RI, et al. Biochem Pharmacol, 1986, 35(24), 4523-4527.
| Anwendung: | Apoptosis inducer, trimethylation inhibitor |
| CAS | 120964-45-6 |
| MW: | 298.73 D |
ab 86,00 €
CPI-169 racemate
Artikelnummer: TGM-T6809-100mg
Description: CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CCS(=O)(=O)N1CCC(CC1)C(C)n1c(C)c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2ccccc12....
| Schlagworte: | CPI-169, CPI 169, CPI169 |
| Anwendung: | EZH2 inhibitor |
| CAS | 1450655-76-1 |
| MW: | 528.66 D |
ab 52,00 €
CPI-360
Artikelnummer: TGM-T6810-100mg
Description: CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 µM, EC50: 0.080 µM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. Target: Histone Methyltransferase, Apoptosis. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCOCC4. References: Vatolin S, et al....
| Schlagworte: | CPI360, Synonym 2, Synonym 2, CPI 360 |
| Anwendung: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.53 D |
ab 75,00 €