Zu "K11411" wurden 149 Artikel gefunden!
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cis-trismethoxy Resveratrol
Artikelnummer: TGM-T3330L-100mg
Description: cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 µM) and has anti-mitotic effects. Target: Microtubule Associated. Smiles: C(=C\C1=CC=C(OC)C=C1)\C2=CC(OC)=CC(OC)=C2. References: Schneider Y, et al. Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a...
| Schlagworte: | (Z)-3,5,4'-Trimethoxystilbene |
| Anwendung: | Antiproliferative, antineoplastic, antiangiogenic agent |
| CAS | 94608-23-8 |
| MW: | 270.32 D |
ab 47,00 €
Fisetin
Artikelnummer: TGM-T2879-100mg
Description: Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Target: PPAR, Sirtuin, TNF. Smiles: OC1=C(OC=2C(C1=O)=CC=C(O)C2)C3=CC(O)=C(O)C=C3. References: Kim SC, et al. Fisetin...
| Anwendung: | Sirtuin 1 activator, antioxidant |
| CAS | 528-48-3 |
| MW: | 286.24 D |
ab 41,00 €
CAY10591
Artikelnummer: TGM-T35812-10mg
Description: Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule...
| Schlagworte: | CAY10591 |
| Anwendung: | SIRT1 assays |
| CAS | 839699-72-8 |
| MW: | 367.44 D |
ab 156,00 €
Dihydrocoumarin
Artikelnummer: TGM-T2S0300-1mL
Description: Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 µM and 295 µM, respectively. Target: Sirtuin. Smiles: O=C1CCC2=C(O1)C=CC=C2. References: Podyma W, Baczek K,...
| Schlagworte: | Chroman-2-one, melilotin, Hydrocoumarin, 2-chromanone, 3,4-dihydrocoumarin |
| Anwendung: | Coumarin, SIRT1/2 inhibitor, flavoring agent |
| CAS | 119-84-6 |
| MW: | 148.16 D |
30,00 €
Cambinol
Artikelnummer: TGM-T4019-100mg
Description: Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 µM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50...
| Schlagworte: | SIRT1/2 Inhibitor IV, NSC 112546 |
| Anwendung: | SIRT1/2 inhibitor |
| CAS | 14513-15-6 |
| MW: | 360.43 D |
ab 34,00 €
CAY10602
Artikelnummer: TGM-T4062-100mg
Description: CAY10602 is a SIRT1 activator derived from high throughput screening for compounds that enhance SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays indicate that CAY10602 dose-dependently suppresses NF-kappaB-dependent induction of TNF-alpha by lipopolysaccharide in THP-1...
| Anwendung: | SIRT1 activator |
| CAS | 374922-43-7 |
| MW: | 418.44 D |
ab 47,00 €
Agrimol B
Artikelnummer: TGM-T4S1173-100mg
Description: 1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb. Target: PPAR, Sirtuin. Smiles: CCCC(=O)c1c(O)c(Cc2c(O)c(Cc3c(O)c(C)c(OC)c(C(=O)CCC)c3O)c(O)c(C(=O)[C@@H](C)CC)c2O)c(O)c(C)c1OC. References: Chun S B, Yang B R, Choi C W, et al. Antibacterial Activities against Plant...
| Anwendung: | Polyphenol, adipogenesis inhibitory / anticancer agent |
| CAS | 55576-66-4 |
| MW: | 682.75 D |
ab 113,00 €
Selisistat
Artikelnummer: TGM-T6111-100mg
Description: Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50 = 38 nM) and can be utilized in the study of neurological disorders such as Huntington's chorea. Target: Sirtuin. Smiles: NC(=O)C1CCCC2=C1NC1=CC=C(Cl)C=C21. References: Kabra N, et al. SirT1 is an inhibitor of...
| Schlagworte: | EX-527, SEN0014196 |
| Anwendung: | SIRT1 inhibitor |
| CAS | 49843-98-3 |
| MW: | 248.71 D |
ab 43,00 €
BML-278
Artikelnummer: TGM-T77697-100mg
Description: BML-278 is a SIRT1 activator with an EC150 of 1 µM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying...
| Schlagworte: | BML278, BML 278 |
| Anwendung: | SIRT1 activator |
| CAS | 120533-76-8 |
| MW: | 391.46 D |
ab 57,00 €
Sirtuin-1 inhibitor 1
Artikelnummer: TGM-T79903-1mg
Description: Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism. Target: Sirtuin. Smiles: O=C(NC=1C=CC=CC1)NC2=CC=C(C=C2)NC(=O)C=3C=CC=CC3. References: Anastasiia Gryniukova, et al. AI-Powered Virtual Screening of Large Compound...
| Anwendung: | Sirtuin-1 inhibitor |
| CAS | 945114-10-3 |
| MW: | 331.37 D |
97,00 €
YK-3-237
Artikelnummer: TGM-T9320-100mg
Description: YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53. Target: Sirtuin. Smiles: COc1ccc(\C=C\C(=O)c2cc(OC)c(OC)c(OC)c2)cc1B(O)O
| Schlagworte: | B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid |
| Anwendung: | SIRT1 activator |
| CAS | 1215281-19-8 |
| MW: | 372.18 D |
ab 34,00 €
3,4',5-Trismethoxybenzophenone
Artikelnummer: TGM-T84553-10mg
Description: 3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1]. Target: Others. Smiles: C(=O)(C1=CC(OC)=CC(OC)=C1)C2=CC=C(OC)C=C2
| Anwendung: | Antioxidant, antiproliferative agent |
| CAS | 94709-12-3 |
| MW: | 272.3 D |
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