Zu "K11348" wurden 22 Artikel gefunden!
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OF-1
Artikelnummer: TGM-T2127-1mg
Description: OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain. Target: Epigenetic Reader Domain. Smiles: COc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C. References: Structural Genomics Consortium (SGC).
| Anwendung: | BRPF probe |
| CAS | 919973-83-4 |
| MW: | 440.31 D |
ab 33,00 €
GSK-5959
Artikelnummer: TGM-T1972-100mg
Description: GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Target: Epigenetic Reader Domain. Smiles:...
| Anwendung: | BRPF1 (Peregrin) bromodomain inhibitor |
| CAS | 901245-65-6 |
| MW: | 394.47 D |
ab 52,00 €
PFI-4
Artikelnummer: TGM-T1973-100mg
Description: PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor. Target: Epigenetic Reader Domain. Smiles: COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCC1. References: Demont EH, et al. ACS Med Chem Lett. 2014, 5(11), 1190-1195.
| Schlagworte: | PFI4 |
| Anwendung: | BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.44 D |
ab 40,00 €
PFI-4
Artikelnummer: Cay17663-1
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple...
| Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Anwendung: | BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.4 D |
ab 61,00 €
GSK6853
Artikelnummer: Cay20985-5
GSK6853 is a chemical probe for the bromodomain of BRPF1 that displays a TR-FRET pIC50 value of 8.1 and a BROMOscan pKd value of 9.5. It exhibits >1,600-fold selectivity for BRPF1 over all other bromodomains in a BROMOscan assay and shows cellular target engagement with a pIC50 value of 7.7 in a NanoBRET assay...
| Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
| Anwendung: | Peregrin inhibitor |
| CAS | 1910124-24-1 |
| MW: | 409.5 D |
ab 44,00 €
NI-57
Artikelnummer: Cay17662-1
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
| Schlagworte: | 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide |
| Anwendung: | BRPF bromodomain inhibitor |
| CAS | 1883548-89-7 |
| MW: | 383.4 D |
ab 44,00 €
GSK5959
Artikelnummer: Cay18123-5
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
| Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
| Anwendung: | Cell-permeable BRPF1 bromodomain inhibitor |
| CAS | 901245-65-6 |
| MW: | 394.5 D |
ab 44,00 €
OF-1
Artikelnummer: Cay17124-1
OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1...
| Schlagworte: | 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide |
| Anwendung: | BRPF probe |
| CAS | 919973-83-4 |
| MW: | 440.3 D |
ab 67,00 €
NI-42
Artikelnummer: Cay28293-5
NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid...
| Schlagworte: | 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-benzenesulfonamide |
| Anwendung: | Peregrin/BRPF1 inhibitor |
| CAS | 1884640-99-6 |
| MW: | 353.4 D |
ab 44,00 €
BRPF1 (627-746), human recombinant protein, N-terminal...
Artikelnummer: BPS-31112
Human Bromodomain and PHD finger containing 1, or BRPF1, amino-acids 627 ? 746 (GenBank Accession No. NM_001003694) with N-terminal HIS-tag, MW = 15.1 kDa, expressed in an E. coli expression system.
| Schlagworte: | Peregrin, Protein Br140, Bromodomain and PHD finger-containing protein 1, |
| Anwendung: | BRD binding assays, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 14.3 kD |
461,00 €
PFI-4
Artikelnummer: SYN-3047-M001
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues...
| Schlagworte: | N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Anwendung: | Potent,selective BRPF1 bromodomain inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.5 D |
ab 77,00 €
Anti-BRPF1
Artikelnummer: ATA-HPA003359.100
Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone...
| Schlagworte: | Anti-Peregrin, Anti-Protein Br140, Anti-Bromodomain and PHD finger-containing protein 1 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 239,00 €