Zu "K11219" wurden 56 Artikel gefunden!
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NEU
Non-receptor tyrosine-protein kinase TYK2 (TYK2),...
Artikelnummer: CSB-BP025391HU5.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 589-875aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: ITQLSHLGQG TRTNVYEGRL RVEGSGDPEE GKMDDEDPLV PGRDRGQELR VVLKVLDPSH HDIALAFYET ASLMSQVSHT HLAFVHGVCV RGPENIMVTE YVEHGPLDVW LRRERGHVPM AWKMVVAQQL...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2, Recombinant Human Non-receptor tyrosine-protein kinase TYK2... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 34.4 kD |
ab 474,00 €
NEU
Non-receptor tyrosine-protein kinase TYK2 (TYK2),...
Artikelnummer: CSB-EP025391HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 556-871aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2, Recombinant Human Non-receptor tyrosine-protein kinase TYK2... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 42.6 kD |
ab 283,00 €
NEU
Non-receptor tyrosine-protein kinase TYK2 (TYK2),...
Artikelnummer: CSB-EP025391HU1a0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 556-871aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV SHTHLAFVHG VCVRGPENIM VTEYVEHGPL...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2, Recombinant Human Non-receptor tyrosine-protein kinase TYK2... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 39.3 kD |
ab 283,00 €
NEU
Non-receptor tyrosine-protein kinase TYK2 (TYK2),...
Artikelnummer: CSB-EP025391HU5.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 589-875aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: ITQLSHLGQG TRTNVYEGRL RVEGSGDPEE GKMDDEDPLV PGRDRGQELR VVLKVLDPSH HDIALAFYET ASLMSQVSHT HLAFVHGVCV RGPENIMVTE YVEHGPLDVW LRRERGHVPM AWKMVVAQQL ASALSYLENK...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2, Recombinant Human Non-receptor tyrosine-protein kinase TYK2... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 37.9 kD |
ab 283,00 €
Zasocitinib
Artikelnummer: Cay35682-1
Zasocitinib is an inhibitor of tyrosine kinase 2 (TYK2). It selectively binds to the TYK2 Janus homology (JH2) domain (Kd = 0.0038 nM) over the JAK1 and JAK2 JH2 domains (Kds = 4,975 and 23,000 nM, respectively). Zasocitinib inhibits the production of chemokine (C-X-C motif) ligand 10 (CXCL10) induced by IFN-alpha...
| Schlagworte: | NDI-034858, TAK-279,... |
| Anwendung: | TYK2 inhibitor |
| CAS | 2272904-53-5 |
| MW: | 460.5 D |
ab 409,00 €
Human Tyk2 (Tyrosine Kinase 2) ELISA Kit
Artikelnummer: ELK-ELK2077.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Tyk2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Tyk2. Next,...
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
TYK2 (Tyrosine Kinase 2) Assay Kit
Artikelnummer: BPS-79527
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that play an important role in cytokine-mediated signaling. This family includes four protein kinases, Jak1, Jak2, Jak3 and Tyk2. Various studies have suggested that regulation of Jak activity should be a promising approach to combat...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2 |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
825,00 €
TYK2, FLAG-Tag
Artikelnummer: BPS-100523
Human Tyrosine Kinase 2 (TYK2), also known as JTK1, IMD35, and Non-Receptor Tyrosine-Protein Kinase TYK2, Genbank Accession No. NM_003331, a.a. 575-869 with N-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 34 kDa.
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2, |
| Anwendung: | Kinase assays |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 34 kD |
555,00 €
BMS 986165
Artikelnummer: Cay33524-1
BMS 986165 is an allosteric inhibitor of tyrosine kinase 2 (TYK2, IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain). It is selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and bone morphogenetic protein receptor type II (BMPR2, IC50s = 1...
| Schlagworte: | 6-[(cyclopropylcarbonyl)amino]-4-[[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino]-N-(methyl-d3)-3-pyridazinecar... |
| Anwendung: | TYK2 allosteric inhibitor |
| CAS | 1609392-27-9 |
| MW: | 425.5 D |
ab 60,00 €
Cerdulatinib
Artikelnummer: Cay20076-5
Cerdulatinib is a dual inhibitor of spleen tyrosine kinase (Syk) and Janus kinases (JAK, IC50s = 32, 12, 6, 8, and 0.5 nM for Syk, JAK1, JAK2, JAK3, and TYK2, respectively) and also exhibits nanomolar inhibition of other kinases. Syk is involved in the B cell receptor (BCR) pathway, and cerdulatinib inhibits...
| Schlagworte: | PRT062070, PRT2070, 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide |
| Anwendung: | Syk / JAK1 / JAK2 / JAK3 / TYK2 inhibitor |
| CAS | 1198300-79-6 |
| MW: | 445.5 D |
ab 84,00 €
Peficitinib
Artikelnummer: Cay22954-5
Peficitinib is an inhibitor of JAK (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively). It is 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5...
| Schlagworte: | ASP015K, JNJ-54781532, 4-[(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, stereoisomer |
| Anwendung: | JAK1 / JAK2 / JAK3 / TYK2 inhibitor |
| CAS | 944118-01-8 |
| MW: | 326.4 D |
ab 60,00 €
Tyk2(JTK1), active human recombinant, N-terminal His-tag
Artikelnummer: BPS-40285
Active recombinant human Tyk2 (Tyrosine Kinase 2, alsoknown as JTK1), GenBank Accession No. NM_003331, a.a. 871-1187(end), with N-terminal His-tag, MW=38 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| MW: | 38 kD |
525,00 €