Zu "K11219" wurden 60 Artikel gefunden!
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TYK2 JH2 Domain (human, recombinant, aa 575-869)
Artikelnummer: Cay42270-20
Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling. It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, an autoinhibitory and catalytically inactive...
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2, Non-receptor tyrosine-protein kinase TYK2 |
| Anwendung: | Active enzyme |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
512,00 €
NDI-034858
Artikelnummer: TGM-T62902-100mg
Description: NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23. Target: IL Receptor, Tyrosine Kinases. Smiles:...
| Schlagworte: | NDI-03485, TAK-279 |
| Anwendung: | TYK2 inhibitor |
| CAS | 2272904-53-5 |
| MW: | 460.49 D |
ab 261,00 €
Ropsacitinib
Artikelnummer: TGM-T13237L-10mg
Description: Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM). Target: Tyrosine Kinases. Smiles: C(C#N)[C@@]1(C[C@H](C#N)C1)N2C=C(C=N2)C=3C=4N(C=C(N3)C=5C=NN(C)C5)N=CC4. References: Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine...
| Schlagworte: | Tyk2-IN-8, PF-06826647 |
| Anwendung: | Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2) |
| CAS | 2127109-84-4 |
| MW: | 383.41 D |
ab 242,00 €
Deucravacitinib
Artikelnummer: TGM-T14687-100mg
Description: Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated...
| Schlagworte: | BMS-986165 |
| Anwendung: | Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2) |
| CAS | 1609392-27-9 |
| MW: | 425.46 D |
ab 63,00 €
SAR-20347
Artikelnummer: TGM-T4210-100mg
Description: SAR-20347 is an inhibitor of TYK2 and JAK1/2/3, with IC50 values of 0.6 nM, 23 nM, 26 nM, and 41 nM, respectively. Target: Tyrosine Kinases, JAK. Smiles: NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)N1CCOCC1)-c1c(F)cccc1Cl. References: Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced...
| Schlagworte: | SAR20347 |
| Anwendung: | JAK family kinase inhibitor |
| CAS | 1450881-55-6 |
| MW: | 444.84 D |
ab 31,00 €
TYK2 Protein, Human, Recombinant (E. coli, His)
Artikelnummer: TGM-TMPH-01777-100ug
Description: TYK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.9 kDa and the accession number is P29597.
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2 |
| MW: | 37.9 kD |
ab 281,00 €
TYK2 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01778-100ug
Description: TYK2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 34.4 kDa and the accession number is P29597.
| Schlagworte: | Non-receptor tyrosine-protein kinase TYK2, TYK2 |
| MW: | 34.4 kD |
ab 491,00 €
Anti-TYK2
Artikelnummer: CSB-PA004352.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-TYK2, EC=2.7.10.2, Anti-Non-receptor tyrosine-protein kinase TYK2, JTK 1 antibody, JTK1 antibody, Non receptor... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, monkey |
ab 126,00 €
Anti-Phospho-TYK2 (Tyr1054)
Artikelnummer: CSB-PA154201.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-phospho-TYK2, EC=2.7.10.2, Anti-phospho-Non-receptor tyrosine-protein kinase TYK2, JTK 1 antibody, JTK1 antibody, Non... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €
Anti-TYK2 (Ab-1054)
Artikelnummer: CSB-PA906130.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-TYK2, EC=2.7.10.2, Anti-Non-receptor tyrosine-protein kinase TYK2, JTK 1 antibody, JTK1 antibody, Non receptor... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
283,00 €
PF-06826647
Artikelnummer: Cay37577-1
PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2, IC50 = 15 nM). It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.)...
| Schlagworte: | Ropsacitinib, TYK2 Inhibitor 8, TYK2-IN-8,... |
| Anwendung: | TYK2 inhibitor |
| CAS | 2127109-84-4 |
| MW: | 383.4 D |
ab 81,00 €
Bayer 18
Artikelnummer: Cay41124-1
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). It is selective for TYK2 over JAK2, cyclin-dependent kinase 2 (Cdk2), and VEGFR2 (IC50s = 2,000, 1,790, and 3,520 nM, respectively).Formal Name:...
| Schlagworte: | N-(1,1-dimethylethyl)-N'-[3-[[5-fluoro-4-[(2-hydroxy-1,1-dimethylethyl)amino]-2-pyrimidinyl]amino]phenyl]-urea |
| Anwendung: | TYK2 inhibitor |
| CAS | 1251752-12-1 |
| MW: | 390.5 D |
ab 126,00 €