Zu "K11218" wurden 69 Artikel gefunden!
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PF-06651600
Artikelnummer: Cay21054-10
PF-06651600 is a covalent inhibitor of JAK3 (IC50 = 33.1 nM). It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = >10,000 for all) and a panel of 304 other kinases at 1 µM. PF-06651600 inhibits STAT5, STAT6, and STAT3 phosphorylation induced by IL-2, IL-4, or IL-21, respectively, in...
| Schlagworte: | Ritlecitinib, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one |
| Anwendung: | Covalent JAK3 inhibitor |
| CAS | 1792180-81-4 |
| MW: | 285.3 D |
ab 110,00 €
Tofacitinib, Free Base (Tasocitinib, CP-690550, Xeljanz,...
Artikelnummer: LC-T-1377_1g
Soluble in DMSO at 100 mg/mL, soluble in ethanol at 100 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Anwendung: | JAK3 inhibitor |
| CAS | 477600-75-2 |
| MW: | 312,37 D |
ab 94,00 €
Human JAK3 (Janus Kinase 3) ELISA Kit
Artikelnummer: ELK-ELK4794.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human JAK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human JAK3. Next,...
| Schlagworte: | L-JAK, JAK-3, EC=2.7.10.2, Janus kinase 3, Leukocyte janus kinase, Tyrosine-protein kinase JAK3 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat JAK3 (Janus Kinase 3) ELISA Kit
Artikelnummer: ELK-ELK6617.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat JAK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat JAK3. Next,...
| Schlagworte: | JAK-3, EC=2.7.10.2, Janus kinase 3, Tyrosine-protein kinase JAK3 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
JAK3-IN-2
Artikelnummer: Cay37344-100
JAK3-IN-2 is an inhibitor of JAK3 (Ki = 0.07 nM). It is selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively). JAK3-IN-2 inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM). In vivo, JAK3-IN-2 (100, 300, and 600 mg/kg) reduces paw swelling and ankle bone loss in a rat...
| Schlagworte: | Janus-Associated Kinase 3 Inhibitor 2, JAK3-Inhibitor 2,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.4 D |
ab 340,00 €
COVID-19 Forschung
Tofacitinib
Artikelnummer: AG-CR1-3625-M005
Off-white to pale yellow solid. Soluble in DMSO or ethanol. Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity, Immunosuppressive and anti-inflammatory agent, Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional...
| Schlagworte: | CP-690550, Xeljanz, Tasocitinib |
| Anwendung: | Cell-permeable JAK3 inhibitor |
| CAS | 477600-75-2 |
| MW: | 312,4 D |
ab 77,00 €
Tofacitinib (citrate)
Artikelnummer: Cay11598-5
Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits...
| Schlagworte: | Tofacitinib citrate,... |
| Anwendung: | JAK inhibitor |
| CAS | 540737-29-9 |
| MW: | 504.5 D |
ab 92,00 €
JAK Inhibitor I
Artikelnummer: Cay15146-500
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
ab 39,00 €
VX-509
Artikelnummer: Cay19513-1
VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes. At 10-100 mg/kg, it has been shown to dose dependently reduce proinflammatory...
| Schlagworte: | Decernotinib, VRT-831509,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 944842-54-0 |
| MW: | 392.4 D |
ab 48,00 €
WHI-P131
Artikelnummer: Cay10011246-10
Janus kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STATs). JAK3 is abundantly expressed in normal lymphoid cells as well as human...
| Schlagworte: | Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Anwendung: | JAK3 inhibitor |
| CAS | 202475-60-3 |
| MW: | 297.3 D |
ab 42,00 €
ZM 39923 (hydrochloride)
Artikelnummer: Cay16729-1
ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively). In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the...
| Schlagworte: | JAK3 Inhibitor IV, Janus-Associated Kinase 3 Inhibitor IV,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1021868-92-7 |
| MW: | 367.9 D |
ab 60,00 €
FM-381
Artikelnummer: Cay23204-1
FM-381 is a potent inhibitor of JAK3 (IC50 = 127 pM). It is 400-, 2,700-, and 3,600-fold selective for JAK3 over JAK1, JAK2, and TYK3 and only inhibits 11 kinases by less than 50 percent in a panel of 410 kinases when used at a concentration of 500 nM. FM-381 (1 µM) blocks JAK3-dependent STAT5 phosphorylation but...
| Schlagworte: | (E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide |
| Anwendung: | Potent JAK3 inhibitor |
| MW: | 428.5 D |
ab 60,00 €