Zu "K11218" wurden 88 Artikel gefunden!
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WHI-P154
Artikelnummer: TGM-T1985-100mg
Description: WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor. Target: VEGFR, JAK, Apoptosis, EGFR, Src. Smiles: COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC. References: Changelian PS,Blood, 2008, 111(4), 2155-2157.
| Schlagworte: | Jak3 inhibitor ii |
| Anwendung: | JAK3 inhibitor |
| CAS | 211555-04-3 |
| MW: | 376.2 D |
ab 35,00 €
ZM39923 hydrochloride
Artikelnummer: TGM-T6145-100mg
Description: ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase. Target: EGFR, Others, JAK. Smiles: Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1. References: Brown GR, et...
| Schlagworte: | JAK3 Inhibitor IV, ZM 39923 HCl |
| Anwendung: | JAK3 inhibitor |
| CAS | 1021868-92-7 |
| MW: | 367.91 D |
ab 53,00 €
JAK3 covalent inhibitor-1
Artikelnummer: TGM-T11709-100mg
Description: JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs. Target: JAK. Smiles:...
| Anwendung: | JAK3 covalent inhibitor |
| CAS | 2300106-50-5 |
| MW: | 448.47 D |
ab 2.669,00 €
TCS 21311
Artikelnummer: TGM-T17019-1mg
Description: TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCalpha, PKCtheta, and GSK3beta (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2. Target: JAK, GSK-3, PKC. Smiles:...
| Schlagworte: | NIBR3049 |
| Anwendung: | JAK3 inhibitor |
| CAS | 1260181-14-3 |
| MW: | 526.51 D |
97,00 €
WHI-P258
Artikelnummer: TGM-T2035-100mg
Description: WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new therapeutics. Target: JNK, JAK, EGFR. Smiles: COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC. References: Fry DW, et al. Science. 1994, 265(5175),...
| Anwendung: | Negative control (JAK3 inhibition) |
| CAS | 21561-09-1 |
| MW: | 281.31 D |
ab 51,00 €
JANEX-1
Artikelnummer: TGM-T2045-100mg
Description: JANEX-1 (Jak3 inhibitor I) is a cell-permeable, reversible, effective, ATP-competitive, and selective inhibitor of JAK3 (IC50: 78 µM), little inhibitory against JAK1/2, or Zap/Syk or SRC tyrosine kinases. Target: JAK. Smiles: COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC. References: Sudbeck EA, et al....
| Schlagworte: | Jak3 inhibitor I, WHI-P131 |
| Anwendung: | JAK3 inhibitor |
| CAS | 202475-60-3 |
| MW: | 297.31 D |
ab 37,00 €
Decernotinib
Artikelnummer: TGM-T2636-1mg
Description: Decernotinib (VRT-831509)(VX-509, VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM, IC50 is 50-170 nM in cellular assays. Target: JAK, Tyrosine Kinases. Smiles: CC[C@@](C)(Nc1ccnc(n1)-c1c[nH]c2ncccc12)C(=O)NCC(F)(F)F. References: Mahajan S, et al. J Pharmacol Exp...
| Schlagworte: | VRT-831509, VX-509 |
| Anwendung: | Targets Janus kinase 3 [EC:2.7.10.2] (JAK3) |
| CAS | 944842-54-0 |
| MW: | 392.38 D |
ab 44,00 €
WHI-P97
Artikelnummer: TGM-T4657-100mg
Description: WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE...
| Anwendung: | JAK3 inhibitor |
| CAS | 211555-05-4 |
| MW: | 455.1 D |
ab 33,00 €
JAK3-IN-6
Artikelnummer: TGM-T5492-100mg
Description: JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM. Target: JAK. Smiles: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12. References: Elwood F, et al. Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor. J...
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.37 D |
ab 34,00 €
Ritlecitinib
Artikelnummer: TGM-T5382-100mg
Description: Ritlecitinib (PF-06651600) is a potent JAK3-selective inhibitor (IC50: 33.1 nM). Target: JAK. Smiles: C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12. References: Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or...
| Schlagworte: | PF-06651600 |
| Anwendung: | Covalent JAK3 inhibitor |
| CAS | 1792180-81-4 |
| MW: | 285.34 D |
ab 39,00 €
Anti-Phospho-JAK3 (Y785)
Artikelnummer: CSB-PA011292.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-JAK-3, Anti-phospho-L-JAK, EC=2.7.10.2, Anti-phospho-Janus kinase 3, Anti-phospho-Leukocyte janus kinase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-JAK3
Artikelnummer: CSB-PA011293.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-JAK-3, Anti-L-JAK, EC=2.7.10.2, Anti-Janus kinase 3, Anti-Leukocyte janus kinase, Anti-Tyrosine-protein kinase JAK3,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €