Zu "K11218" wurden 89 Artikel gefunden!
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JAK3 Kinase Domain (human, recombinant)
Artikelnummer: Cay42275-20
JAK3 is a non-receptor tyrosine kinase that has roles in cytokine signaling and immune cell function.1,2 It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal kinase domain.2,3 JAK3 is constitutively expressed in natural killer (NK) cells and thymocytes and...
| Schlagworte: | JAK-3, L-JAK, EC=2.7.10.2, Janus kinase 3, Leukocyte janus kinase, Tyrosine-protein kinase JAK3 |
| Anwendung: | Enzyme assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 37 kD |
513,00 €
JAK3 JH2 Domain (human, recombinant, aa 511-790) - Biotinyla
Artikelnummer: Cay42276-10
JAK3 is a non-receptor tyrosine kinase that has roles in cytokine signaling and immune cell function.1,2 It is composed of N-terminal FERM and SH2 domains, an autoinhibitory JH2 pseudokinase domain, and a C-terminal kinase domain.3,2,4 JAK3 is constitutively expressed in natural killer (NK) cells and thymocytes and...
| Schlagworte: | JAK-3, L-JAK, EC=2.7.10.2, Janus kinase 3, Leukocyte janus kinase, Tyrosine-protein kinase JAK3 |
| Anwendung: | Enzyme assays |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 34 kD |
ab 486,00 €
JAK3 JH2 Domain (human, recombinant, aa 511-790)
Artikelnummer: Cay42277-20
JAK3 is a non-receptor tyrosine kinase that has roles in cytokine signaling and immune cell function.1,2 It is composed of N-terminal FERM and SH2 domains, an autoinhibitory JH2 pseudokinase domain, and a C-terminal kinase domain.2,3 JAK3 is constitutively expressed in natural killer (NK) cells and thymocytes and...
| Schlagworte: | JAK-3, L-JAK, EC=2.7.10.2, Janus kinase 3, Leukocyte janus kinase, Tyrosine-protein kinase JAK3 |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 32 kD |
513,00 €
WHI-P258
Artikelnummer: TGM-T2035-100mg
Description: WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new therapeutics. Target: JNK, JAK, EGFR. Smiles: COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC. References: Fry DW, et al. Science. 1994, 265(5175),...
| Anwendung: | Negative control (JAK3 inhibition) |
| CAS | 21561-09-1 |
| MW: | 281.31 D |
ab 30,00 €
JANEX-1
Artikelnummer: TGM-T2045-100mg
Description: JANEX-1 (Jak3 inhibitor I) is a cell-permeable, reversible, effective, ATP-competitive, and selective inhibitor of JAK3 (IC50: 78 µM), little inhibitory against JAK1/2, or Zap/Syk or SRC tyrosine kinases. Target: JAK. Smiles: COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC. References: Sudbeck EA, et al....
| Schlagworte: | Jak3 inhibitor I, WHI-P131 |
| Anwendung: | JAK3 inhibitor |
| CAS | 202475-60-3 |
| MW: | 297.31 D |
ab 38,00 €
Decernotinib
Artikelnummer: TGM-T2636-1mg
Description: Decernotinib (VRT-831509)(VX-509, VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM, IC50 is 50-170 nM in cellular assays. Target: JAK, Tyrosine Kinases. Smiles: CC[C@@](C)(Nc1ccnc(n1)-c1c[nH]c2ncccc12)C(=O)NCC(F)(F)F. References: Mahajan S, et al. J Pharmacol Exp...
| Schlagworte: | VRT-831509, VX-509 |
| Anwendung: | Targets Janus kinase 3 [EC:2.7.10.2] (JAK3) |
| CAS | 944842-54-0 |
| MW: | 392.38 D |
ab 45,00 €
JAK3-IN-6
Artikelnummer: TGM-T5492-100mg
Description: JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM. Target: JAK. Smiles: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12. References: Elwood F, et al. Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor. J...
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.37 D |
ab 34,00 €
Ritlecitinib
Artikelnummer: TGM-T5382-100mg
Description: Ritlecitinib (PF-06651600) is a potent JAK3-selective inhibitor (IC50: 33.1 nM). Target: JAK. Smiles: C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12. References: Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or...
| Schlagworte: | PF-06651600 |
| Anwendung: | Covalent JAK3 inhibitor |
| CAS | 1792180-81-4 |
| MW: | 285.34 D |
ab 40,00 €
Ritlecitinib tosylate
Artikelnummer: TGM-T69822-100mg
Description: Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical...
| Anwendung: | Targets Janus kinase 3 [EC:2.7.10.2] (JAK3) |
| CAS | 2192215-81-7 |
| MW: | 457.549 D |
ab 1.520,00 €
WHI-P154
Artikelnummer: TGM-T1985-100mg
Description: WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor. Target: VEGFR, JAK, Apoptosis, EGFR, Src. Smiles: COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC. References: Changelian PS,Blood, 2008, 111(4), 2155-2157.
| Schlagworte: | Jak3 inhibitor ii |
| Anwendung: | JAK3 inhibitor |
| CAS | 211555-04-3 |
| MW: | 376.2 D |
ab 37,00 €
ZM39923 hydrochloride
Artikelnummer: TGM-T6145-100mg
Description: ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase. Target: EGFR, Others, JAK. Smiles: Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1. References: Brown GR, et...
| Schlagworte: | JAK3 Inhibitor IV, ZM 39923 HCl |
| Anwendung: | JAK3 inhibitor |
| CAS | 1021868-92-7 |
| MW: | 367.91 D |
ab 55,00 €
JAK3 covalent inhibitor-1
Artikelnummer: TGM-T11709-100mg
Description: JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs. Target: JAK. Smiles:...
| Anwendung: | JAK3 covalent inhibitor |
| CAS | 2300106-50-5 |
| MW: | 448.47 D |
ab 2.722,00 €