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Zu "K11217" wurden 99 Artikel gefunden!
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NEU
Artikelnummer: CSB-EP011930HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 850-1154aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: EQNPDIVSEK KPATEVDPTH FEKRFLKRIR DLGEGHFGKV ELCRYDPEGD NTGEQVAVKS LKPESGGNHI ADLKKEIEIL RNLYHENIVK YKGICTEDGG NGIKLIMEFL PSGSLKEYLP KNKNKINLKQ QLKYAVQICK...
Schlagworte: | JAK1, JAK-1, JAK1A, Janus kinase 1, Tyrosine-protein kinase JAK1, Recombinant Human Tyrosine-protein kinase JAK1 (Jak1),... |
Anwendung: | Activity not tested |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 38.9 kD |
ab 283,00 €
Artikelnummer: Cay39890-10
AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM). It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2, IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD...
Schlagworte: | Londamocitinib,... |
Anwendung: | JAK1 inhibitor |
CAS | 2241039-81-4 |
MW: | 599.7 D |
ab 34,00 €
Artikelnummer: ELK-ELK4056.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human JAK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human JAK1. Next,...
Schlagworte: | JAK1, JAK-1, JAK1A, Janus kinase 1, Tyrosine-protein kinase JAK1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-EA340.100
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Protein function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:8232552, PubMed:7615558, PubMed:28111307,...
Schlagworte: | Anti-JAK1, Anti-JAK1A, Anti-JAK-1, Anti-Janus kinase 1, Anti-Tyrosine-protein kinase JAK1, JAK1 Rabbit pAb |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
COVID-19 Forschung
Artikelnummer: AG-CR1-3624-M005
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
Schlagworte: | INCB018424, INC 424 |
Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
CAS | 941678-49-5 |
MW: | 306,4 D |
ab 72,00 €
Artikelnummer: BPS-78891
The JAK1 (JH2 Pseudokinase Domain) Inhibitor Screening Assay Kit is a fluorescence polarization-based assay designed for screening and profiling small molecules that displace the fluorescently labeled probe (JH2 probe 1) from the JH2 pseudokinase domain of JAK1. This kit comes in a convenient 384-well format, with...
Schlagworte: | JAK1, JAK1A, JAK-1, Janus kinase 1, Tyrosine-protein kinase JAK1, |
Anwendung: | Small molecule screening/profiling |
Spezies-Reaktivität: | human |
3.343,00 €
Artikelnummer: Cay17669-5
Filgotinib is a JAK1 inhibitor (IC50 = 10 nM). It is selective for JAK1 over JAK3 (IC50 = 810 nM) but also inhibits JAK2 and tyrosine kinase 2 (Tyk2, IC50s = 28 and 116 nM, respectively), as well as Abl, FLT1, -3, and -4, FMS, Mer, and TBK1 activity by greater than 35% in a panel of 177 tyrosine kinases at 1 µM....
Schlagworte: | GLPG0634,... |
Anwendung: | JAK1 inhibitor |
CAS | 1206161-97-8 |
MW: | 425.5 D |
ab 76,00 €
Artikelnummer: Cay28875-1
Filgotinib-d4 is intended for use as an internal standard for the quantification of filgotinib (Cay-17669) by GC- or LC-MS. Filgotinib is a JAK1 inhibitor (IC50 = 10 nM). It is selective for JAK1 over JAK3 (IC50 = 810 nM) but also inhibits JAK2 and tyrosine kinase 2 (Tyk2, IC50s = 28 and 116 nM, respectively), as...
Schlagworte: | GLPG0634-d4,... |
Anwendung: | GC-MS, LC-MS, internal standard, quantification, JAK1 inhibitor |
CAS | 2041095-50-3 |
MW: | 429.5 D |
ab 409,00 €
Artikelnummer: Cay16246-1
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines....
Schlagworte: | Momelotinib, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide |
Anwendung: | JAK1 / JAK2 inhibitor |
CAS | 1056634-68-4 |
MW: | 414.5 D |
ab 109,00 €
Artikelnummer: Cay15146-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
Anwendung: | JAK2, JAK3, JAK1 inhibitor |
CAS | 457081-03-7 |
MW: | 309.3 D |
ab 39,00 €
Artikelnummer: Cay18722-5
Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 µM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-alpha levels in murine bone marrow-derived...
Schlagworte: | PF-03394197, trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide |
Anwendung: | JAK inhibitor |
CAS | 1208319-26-9 |
MW: | 337.4 D |
ab 46,00 €
Artikelnummer: Cay29706-1
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM). It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2, IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK1), and ROCK2 (IC50s = 120, 920, and 430 nM,...
Schlagworte: | ABT-494, (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide |
Anwendung: | JAK1 inhibitor |
CAS | 1310726-60-3 |
MW: | 380.4 D |
ab 43,00 €