Zu "K11155" wurden 46 Artikel gefunden!
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LCQ-908
Artikelnummer: Cay42025-1
LCQ-908 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT1, IC50 = 57 nM). It is selective for DGAT1 over DGAT2, acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), and ACAT-2 (IC50s = >10,000 nM for all). LCQ-908 (50 µM) also inhibits hepatitis C virus (HCV) replication in HCV-infected Huh7.5 cells. It...
| Schlagworte: | Pradigastat, trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-cyclohexaneacetic acid |
| Anwendung: | DGAT1 inhibitor |
| CAS | 956136-95-1 |
| MW: | 455.5 D |
ab 35,00 €
T863
Artikelnummer: TGM-T4681-100mg
Description: T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 (DGAT-3) causes weight loss, reduction in...
| Schlagworte: | DGAT-3, DGAT-1 inhibitor |
| Anwendung: | DGAT1 inhibitor |
| CAS | 701232-20-4 |
| MW: | 394.47 D |
ab 33,00 €
PF-04620110
Artikelnummer: TGM-T6937-10mg
Description: PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. Target: Acyltransferase, Transferase. Smiles: Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12. References: Dow RL, et al. ACS Med Chem Lett. 2011, 2(5), 407-412.
| Schlagworte: | PF 04620110, PF04620110 |
| Anwendung: | DGAT1 inhibitor |
| CAS | 1109276-89-2 |
| MW: | 396.44 D |
ab 37,00 €
A 922500
Artikelnummer: TGM-T6365-100mg
Description: A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor of human and mouse DGAT-1 with IC50 values of 7 nM and 24 nM, respectively, demonstrating good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Target: Acyltransferase, Transferase. Smiles:...
| Schlagworte: | A922500, DGAT-1 Inhibitor 4a |
| Anwendung: | DGAT-1 inhibitor |
| CAS | 959122-11-3 |
| MW: | 428.48 D |
ab 45,00 €
DGAT-1 inhibitor 2
Artikelnummer: TGM-T11016-100mg
Description: DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor and anti-obesity drug. DGAT-1 (acyl-CoA: diacylglycerol acyltransferase 1) is one of two known DGAT enzymes that catalyze the final step of triglyceride synthesis. Transgenic mice and pharmacological studies indicate that inhibiting DGAT1 is a...
| Anwendung: | DGAT1 (diacylglycerol O-acyltransferase 1) inhibitor |
| CAS | 942999-61-3 |
| MW: | 420.5 D |
ab 58,00 €
Diacylglycerol acyltransferase inhibitor-1
Artikelnummer: TGM-T11037-100mg
Description: Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1. Target: Others. Smiles: O=C1C=2C(=NC=NC2N)OCCN1C3=CC=4C=CN(C4C(=C3)C5CC5)CCC. References: Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol...
| Anwendung: | Diacylglycerol acyltransferase (DGAT1) inhibitor |
| CAS | 1610800-25-3 |
| MW: | 377.44 D |
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Pradigastat
Artikelnummer: TGM-T11827-1mg
Description: Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. Target: Transferase. Smiles: OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(Nc2ccc(nc2)C(F)(F)F)cn1....
| Schlagworte: | ANJ908, LCQ908-NXA, LCQ-908, LCQ908A |
| Anwendung: | Targets diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76] (DGAT1) |
| CAS | 956136-95-1 |
| MW: | 455.47 D |
ab 110,00 €
O-acyltransferase (DGAT1-2), Zea mays, recombinant
Artikelnummer: CSB-CF4808ZAX.100
Organism: Zea mays (Maize). Source: in vitro E.coli expression system. Expression Region: 1-494aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MAPPPSMPAA SDRAGPGRDA GDSSSLRLRR APSADAGDLA GDSSGGLREN GEPQSPTNPP PQEQQQHEML YYRASAPAHR RVKESPLSSD AIFRQSHAGL LNLCIVVLIA...
| Schlagworte: | O-acyltransferase, Recombinant Zea mays O-acyltransferase (DGAT1-2) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | Zea mays (Maize) |
| MW: | 57.8 kD |
ab 1.413,00 €
Diacylglycerol O-acyltransferase 1 (DGAT1), partial,...
Artikelnummer: CSB-CF006817HU1.100
Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 240-488aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: TVSYPDNLTY RDLYYFLFAP TLCYELNFPR SPRIRKRFLL RRILEMLFFT QLQVGLIQQW MVPTIQNSMK PFKDMDYSRI IERLLKLAVP...
| Schlagworte: | ARAT, Diglyceride acyltransferase, ACAT-related gene product 1, Retinol O-fatty-acyltransferase, Diacylglycerol... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | human |
| MW: | 37.1 kD |
ab 775,00 €
Anti-DGAT1
Artikelnummer: CSB-PA794725.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DGAT1. Antigen Species: Human
| Schlagworte: | Anti-ARAT, Anti-ACAT-related gene product 1, Anti-Diglyceride acyltransferase, Anti-Retinol O-fatty-acyltransferase,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Anti-DGAT1
Artikelnummer: CSB-PA932813.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DGAT1. Antigen Species: Human
| Schlagworte: | Anti-ARAT, Anti-ACAT-related gene product 1, Anti-Diglyceride acyltransferase, Anti-Retinol O-fatty-acyltransferase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
PF-04620110
Artikelnummer: Cay16425-10
Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides and has potential roles in obesity, diabetes, and atherosclerosis. PF-04620110 is a potent inhibitor of DGAT-1 (IC50 = 19 nM) that is without effect on DGAT-2. It has high oral bioavailability...
| Schlagworte: | trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid |
| Anwendung: | DGAT1 inhibitor |
| CAS | 1109276-89-2 |
| MW: | 396.4 D |
ab 123,00 €