Zu "K10951" wurden 40 Artikel gefunden!
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Furosemide-d5
Artikelnummer: TGM-TMIH-0248-10mg
Description: Furosemide-d5 is a deuterated compound of Furosemide. Smiles: [2H]C1=C([2H])C([2H])=C(O1)C([2H])([2H])NC1=C(C=C(C(Cl)=C1)S(N)(=O)=O)C(O)=O
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, NKCC inhibitor |
| CAS | 1189482-35-6 |
| MW: | 335.78 D |
ab 404,00 €
Piretanide
Artikelnummer: TGM-T19788-1mL
Description: Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic. Target: Others. Smiles: NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc1ccccc1)C(O)=O. References: Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD. Blood pressure-lowering efficacy of loop diuretics...
| Schlagworte: | Tauliz, Eurelix, Arelix |
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 55837-27-9 |
| MW: | 362.4 D |
ab 35,00 €
Torsemide
Artikelnummer: TGM-T1410-1mL
Description: Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life. Target: Na-K-Cl cotransporter. Smiles:...
| Schlagworte: | Torasemide, JDL-464, AC-4464 |
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 56211-40-6 |
| MW: | 348.42 D |
ab 31,00 €
Tienilic Acid
Artikelnummer: TGM-T36125-100mg
Description: Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity. Target: P450. Smiles: C(=O)(C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1)C2=CC=CS2. References: Levron, J.C., et al. Pharmacokinetic study of 2,3-dichloro 4- (2-thienyl keto14C) phenoxyacetic acid (tienilic acid) in animals. European Journal of Drug...
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 40180-04-9 |
| MW: | 331.17 D |
ab 39,00 €
Furosemide sodium
Artikelnummer: TGM-T35336-1mL
Description: Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for alpha6-containing receptors than alpha1-containing receptors. Furosemide sodium...
| Schlagworte: | Frusemide Sodium, Lasix |
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 41733-55-5 |
| MW: | 352.73 D |
ab 30,00 €
Muzolimine
Artikelnummer: TGM-T33534-1mL
Description: Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. Target: Others. Smiles: C(C)(N1C(=O)CC(N)=N1)C2=CC(Cl)=C(Cl)C=C2. References: Grima M, Michel B,...
| Schlagworte: | Muzoliminum, Muzolimina, Edrul |
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 55294-15-0 |
| MW: | 272.13 D |
136,00 €
Alilusem
Artikelnummer: TGM-T29864-25mg
Description: Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension. Target: Others. Smiles: [K].Cc1ccccc1C(=O)N1CCC(=NOS(O)(=O)=O)c2ccc(Cl)cc12 , w:14.14, . References: Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of the uptake mechanism for a novel loop...
| Schlagworte: | D09772, M17055, Alilusem potassium, M 17055 |
| Anwendung: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| CAS | 114417-20-8 |
| MW: | 433.92 D |
ab 1.491,00 €
Bumetanide
Artikelnummer: Cay14630-1
Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1, IC50 = 0.68 µM). It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35 (GPR35, EC50 = 10 µM). It also inhibits various carbonic anhydrases. Bumetanide (0.1 mg/kg) increases urine flow and sodium and...
| Schlagworte: | PF 1593, Ro 10-6338, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoic acid |
| Anwendung: | NKCC1/2 inhibitor |
| CAS | 28395-03-1 |
| MW: | 364.4 D |
ab 60,00 €
Furosemide-d5
Artikelnummer: Cay31789-1
Furosemide-d5 is intended for use as an internal standard for the quantification of furosemide (Cay-17273) by GC- or LC-MS. Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both). In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in...
| Schlagworte: | Frusemide-d5, 4-chloro-2-(((furan-2-yl-d3)methyl-d2)amino)-5-sulfamoylbenzoic acid |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, NKCC inhibitor |
| CAS | 1189482-35-6 |
| MW: | 335.8 D |
442,00 €
Bumetanide
Artikelnummer: LKT-B8248.250
Bumetanide binds to Na-K-Cl co-transporter and inhibits its action.
| Anwendung: | Metabolic studies |
| CAS | 28395-03-1 |
| MW: | 364,42 D |
ab 149,00 €
Furosemide
Artikelnummer: Cay17273-1
Furosemide is a loop diuretic and an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Kis = ~10 µM for both). In vivo, furosemide (0.1 mg/kg, p.o.) increases diuresis in beagle dogs. Furosemide (30 mg/kg) reduces ventricular collagen deposition and fibrosis in a rat model of dilated...
| Schlagworte: | Frusemide, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoic acid |
| Anwendung: | NKCC inhibitor |
| CAS | 54-31-9 |
| MW: | 330.7 D |
ab 43,00 €
Bumetanide-d5
Artikelnummer: Cay26773-500
Bumetanide-d5 is intended for use as an internal standard for the quantification of bumetanide (Cay-14630) by GC- or LC-MS. Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1, IC50 = 0.68 µM). It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35...
| Schlagworte: | 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-d5-benzoic acid |
| Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Na-K-Cl cotransporter inhibitor |
| CAS | 1216739-35-3 |
| MW: | 369.4 D |
ab 147,00 €