Zu "K10807" wurden 73 Artikel gefunden!
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Ribonucleoside-diphosphate reductase large subunit...
Artikelnummer: CSB-EP020518HUc7.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-792aa. Protein Length: Full Length. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST LDIVLANKDR...
| Schlagworte: | RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 97 kD |
ab 219,00 €
Acelarin
Artikelnummer: TGM-T4060-100mg
Description: Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine. Target: DNA/RNA Synthesis. Smiles: FC1(F)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)[C@H]1O)N4C(=O)N=C(N)C=C4. References: Slusarczyk M, et al. Application of ProTide...
| Schlagworte: | NUC-1031 |
| Anwendung: | Gemcitabine prodrug |
| CAS | 840506-29-8 |
| MW: | 580.47 D |
ab 40,00 €
LY2334737
Artikelnummer: TGM-T4061-100mg
Description: LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity. Target: Virus Protease, Others, Nucleoside Antimetabolite/Analog. Smiles: CCCC(CCC)C(=O)Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1. References: Pratt SE, et al. Human carboxylesterase-2 hydrolyzes the prodrug of...
| Anwendung: | Gemcitabine prodrug form |
| CAS | 892128-60-8 |
| MW: | 389.39 D |
ab 63,00 €
RRM1 Protein, Human, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-03287-50ug
Description: RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the...
| Schlagworte: | R1, ribonucleotide reductase M1, RR1, RIR1 |
| MW: | 117.9 kD |
599,00 €
2',2'-Difluorodeoxyuridine
Artikelnummer: TGM-T67291-100mg
Description: 2',2'-Difluorodeoxyuridine (dFdU), the major metabolite of Gemcitabine, exhibits anticancer and antitumor activities, shows radiosensitization under hypoxic conditions, and can be used to study pancreatic cancer. Target: Drug Metabolite. Smiles: OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)C(F)(F)[C@@H]1O....
| Schlagworte: | dFdU, 2',2'-Difluoro-2'-deoxyuridine |
| Anwendung: | Gemcitabine active metabolite |
| CAS | 114248-23-6 |
| MW: | 264.18 D |
ab 34,00 €
Fludarabine Phosphate
Artikelnummer: TGM-T6501-100mg
Description: Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by...
| Schlagworte: | F-ara-A (NSC 312887) Phosphate, F-ara-AMP, NSC 312887 Phosphate, fludara Phosphate |
| Anwendung: | Targets ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] (RRM1) |
| CAS | 75607-67-9 |
| MW: | 365.21 D |
ab 33,00 €
Gemcitabine hydrochloride
Artikelnummer: TGM-T6069-100mg
Description: Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis. Target: Autophagy, DNA/RNA Synthesis, Apoptosis, Nucleoside...
| Schlagworte: | LY 188011 hydrochloride, Gemzar, LY188011, Gemcitabine HCl |
| Anwendung: | Targets ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] (RRM1) |
| CAS | 122111-03-9 |
| MW: | 299.66 D |
ab 31,00 €
Caracemide
Artikelnummer: TGM-T14864-100mg
Description: Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli and can be utilized in anticancer studies. Target: DNA/RNA Synthesis, Antibacterial, Others. Smiles: CNC(=O)ON(C(C)=O)C(=O)NC. References: Larsen IK, et al. Caracemide, a site-specific irreversible inhibitor of...
| Schlagworte: | NSC-253272 |
| Anwendung: | Targets ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] (RRM1) |
| CAS | 81424-67-1 |
| MW: | 189.17 D |
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Gemcitabine elaidate
Artikelnummer: TGM-T15378-2mg
Description: Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active...
| Schlagworte: | Gemcitabine 5'-elaidate, CP-4126, Gemcitabine (elaidate), CO-101 |
| Anwendung: | Targets ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] (RRM1) |
| CAS | 210829-30-4 |
| MW: | 527.64 D |
ab 297,00 €
Gemcitabine
Artikelnummer: Cay11690-10
Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Cay-31726) and the...
| Schlagworte: | DDFC, LY 188011, NSC 613327, 2'-deoxy-2',2'-difluoro-cytidine |
| Anwendung: | Antiretroviral activity, Apoptosis inducer |
| CAS | 95058-81-4 |
| MW: | 263.2 D |
ab 69,00 €
Ribonucleoside-diphosphate reductase large subunit...
Artikelnummer: CSB-EP020518HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-792aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST LDIVLANKDR...
| Schlagworte: | RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 106.1 kD |
ab 219,00 €
Ribonucleoside-diphosphate reductase large subunit...
Artikelnummer: CSB-YP020518HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-792aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST LDIVLANKDR LNSAIIYDRD...
| Schlagworte: | RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 92.1 kD |
ab 265,00 €