Zu "K10798" wurden 182 Artikel gefunden!
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Olaparib
Artikelnummer: Cay10621-5
Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
| Schlagworte: | AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 763113-22-0 |
| MW: | 434.5 D |
ab 67,00 €
Niraparib
Artikelnummer: TGM-T3231-100mg
Description: Niraparib (MK-4827) is a PARP inhibitor that selectively targets PARP1 and PARP2 (IC50=3.8/2.1 nM), exhibiting antitumor activity, inhibiting DNA damage repair, and inducing apoptosis. Target: Apoptosis, PARP, Others. Smiles: C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1. References: Zhao Q,...
| Schlagworte: | MK-4827 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1038915-60-4 |
| MW: | 320.39 D |
ab 55,00 €
Olaparib
Artikelnummer: TGM-T3015-100mg
Description: Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 µM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity. Target: PARP, Mitophagy, Autophagy....
| Schlagworte: | KU0059436, AZD2281 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 763113-22-0 |
| MW: | 434.46 D |
ab 31,00 €
Pamiparib
Artikelnummer: TGM-T5058-10mg
Description: Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor with IC50 values of 0.9 nM for PARP1 and 0.5 nM for PARP2. It exhibits strong PARP trapping, has the capability to penetrate the brain, and is used for researching various cancers, including solid tumors. Target: PARP....
| Schlagworte: | BGB-290 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1446261-44-4 |
| MW: | 298.31 D |
ab 31,00 €
TIQ-A
Artikelnummer: TGM-T50098-100mg
Description: TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury,...
| Anwendung: | PARP1 inhibitor |
| CAS | 420849-22-5 |
| MW: | 201.24 D |
ab 46,00 €
Rucaparib
Artikelnummer: TGM-T4463-100mg
Description: Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC). Target: PARP. Smiles:...
| Schlagworte: | AG014699, AG-14447, PF-01367338 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 283173-50-2 |
| MW: | 323.36 D |
ab 42,00 €
E7449
Artikelnummer: TGM-T4471-100mg
Description: E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Target: PARP, Others. Smiles: O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23. References:...
| Schlagworte: | UNII-9X5A2QIA7C, Stenoparib |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 1140964-99-3 |
| MW: | 317.34 D |
ab 31,00 €
NMS-P118
Artikelnummer: TGM-T4472-100mg
Description: NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. Target: PARP. Smiles: NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12. References: Papeo G, et al. Discovery of...
| Anwendung: | PARP-1 inhibitor |
| CAS | 1262417-51-5 |
| MW: | 395.42 D |
ab 38,00 €
Talazoparib
Artikelnummer: TGM-T6253-100mg
Description: Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). Target: PARP. Smiles: Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1. References: Wilkerson PM, et al. Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of...
| Schlagworte: | LT-673, BMN-673 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1207456-01-6 |
| MW: | 380.35 D |
ab 37,00 €
UPF 1069
Artikelnummer: TGM-T6181-100mg
Description: UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 µM). It is ~27-fold selective against PARP1. Target: PARP. Smiles: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1. References: Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.
| Anwendung: | PARP inhibitor |
| CAS | 1048371-03-4 |
| MW: | 279.29 D |
ab 31,00 €
Niraparib tosylate
Artikelnummer: TGM-T6892-100mg
Description: Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. Target: Apoptosis, PARP. Smiles: Cc1ccc(cc1)S(O)(=O)=O.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1. References: Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.
| Schlagworte: | MK 4827 tosylate, MK-4827 (tosylate), Niraparib (MK-4827) tosylate |
| Anwendung: | Antineoplastic |
| CAS | 1038915-73-9 |
| MW: | 492.59 D |
ab 40,00 €
6(5H)-Phenanthridinone
Artikelnummer: TGM-T72017-10mg
Description: 6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-kappaB-induced transcription of the genes encoding TNF-alpha, IL-2, and IFN-gamma in...
| Anwendung: | PARP1/2 inhibitor |
| CAS | 1015-89-0 |
| MW: | 195.22 D |
ab 88,00 €