Zu "K10170" wurden 57 Artikel gefunden!
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CL075
Artikelnummer: TGM-T27034-1mg
Description: CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-kappaB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN). Target: NF-kappaB, TLR, MyD88. Smiles: CCCc1nc2c(N)nc3ccccc3c2s1....
| Schlagworte: | CL-075, 3M002 |
| Anwendung: | TLR8 agonist |
| CAS | 256922-53-9 |
| MW: | 243.33 D |
ab 34,00 €
Motolimod
Artikelnummer: TGM-T6898-100mg
Description: Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7. Target: TLR. Smiles: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1ccc(cc1)C(=O)N1CCCC1. References: Lu H, et al. Clin Cancer Res. 2012, 18(2), 499-509.
| Schlagworte: | VTX-2337, VTX-378 |
| Anwendung: | Targets toll-like receptor 8 (TLR8, CD288) |
| CAS | 926927-61-9 |
| MW: | 458.6 D |
ab 51,00 €
CU-CPT-9a
Artikelnummer: TGM-T7317-100mg
Description: CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-. Target: TLR. Smiles: COc1ccc2c(ccnc2c1)-c1ccc(O)c(C)c1. References: Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through...
| Anwendung: | TLR8 antagonist |
| CAS | 2165340-32-7 |
| MW: | 265.31 D |
ab 34,00 €
CU-CPT-8m
Artikelnummer: TGM-T7347-100mg
Description: CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM). Target: TLR. Smiles: Cc1cccc(c1)-c1ccnc2c(cnn12)C(N)=O. References: Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature Chemical...
| Schlagworte: | TLR8-specific antagonist |
| Anwendung: | TLR8 antagonist |
| CAS | 125079-83-6 |
| MW: | 252.27 D |
ab 48,00 €
CU-CPT9b
Artikelnummer: TGM-T7302-100mg
Description: CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8, Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM. Target: TLR. Smiles: Cc1cc(ccc1O)-c1ccnc2cc(O)ccc12. References: Zhang...
| Schlagworte: | CU-CPT-9b, TLR8-specific antagonist 1 |
| Anwendung: | TLR8 antagonist |
| CAS | 2162962-69-6 |
| MW: | 251.28 D |
ab 44,00 €
CU-115
Artikelnummer: TGM-T9645-100mg
Description: CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-alpha and IL-1beta activated by R-848 in THP-1 cells. Target: TLR. Smiles: Fc1cccc(I)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1. References: Rosaura...
| Schlagworte: | N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide |
| Anwendung: | TLR8 antagonist |
| CAS | 2471982-20-2 |
| MW: | 569.21 D |
ab 52,00 €
TLR8 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02212-100ug
Description: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from...
| Schlagworte: | TLR8, Toll-like receptor 8 |
| MW: | 93.5 kD |
ab 226,00 €
Toll-like receptor 8 (TLR8), partial, human, recombinant
Artikelnummer: CSB-YP023607HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 27-827aa. Protein Length: partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: EENFSRSYPC DEKKQNDSVI AECSNRRLQE VPQTVGKYVT ELDLSDNFIT HITNESFQGL QNLTKINLNH NPNVQHQNGN PGIQSNGLNI TDGAFLNLKN LRELLLEDNQ LPQIPSGLPE SLTELSLIQN NIYNITKEGI...
| Schlagworte: | TLR8, CD288, Toll-like receptor 8, Recombinant Human Toll-like receptor 8 (TLR8), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 93.5 kD |
ab 235,00 €
Anti-TLR8
Artikelnummer: CSB-PA080187.100
Host Species: Rabbit. Isotype: IgG. Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity purification. Target Name: TLR8. Antigen Species: Human
| Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, CD 288 antibody, CD288 antibody, CD288 antigen antibody, MGC119599... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-TLR8
Artikelnummer: CSB-PA160291.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TLR8. Antigen Species: Human
| Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, CD 288 antibody, CD288 antibody, CD288 antigen antibody, MGC119599... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 163,00 €
Anti-TLR8
Artikelnummer: CSB-PA261777.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TLR8. Antigen Species: Human
| Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, CD 288 antibody, CD288 antibody, CD288 antigen antibody, MGC119599... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 163,00 €
Anti-TLR8
Artikelnummer: CSB-PA268874.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TLR8. Antigen Species: Human
| Schlagworte: | Anti-TLR8, Anti-CD288, Anti-Toll-like receptor 8, CD 288 antibody, CD288 antibody, CD288 antigen antibody, MGC119599... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 163,00 €