Zu "K10127" wurden 36 Artikel gefunden!
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Anti-HdmX/MDM4
Artikelnummer: A300-287A
Protein function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium]
| Schlagworte: | Anti-MDMX, Anti-MDM4, Anti-Protein Mdmx, Anti-Protein Mdm4, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
SJ-172550
Artikelnummer: TGM-T16888-100mg
Description: SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 µM). Target: Mdm2, E1/E2/E3 Enzyme. Smiles: CCOc1cc(\C=C2/C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC. References: Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr...
| Anwendung: | MDM4 inhibitor |
| CAS | 431979-47-4 |
| MW: | 428.87 D |
ab 37,00 €
XI-006
Artikelnummer: TGM-T6610-100mg
Description: XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 µM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. Target: p53, Mdm2. Smiles: CN1CCN(CC1)c1ccc([N+]([O-])=O)c2no[n+]([O-])c12. References: Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79.
| Schlagworte: | NSC 207895 |
| Anwendung: | MDM4 inhibitor |
| CAS | 58131-57-0 |
| MW: | 279.25 D |
ab 51,00 €
MDMX Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-01125-50ug
Description: MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for...
| Schlagworte: | MDMX, HDMX, MRP1, MDM4, p53 regulator |
| MW: | 17 kD |
587,00 €
Protein Mdm4 (MDM4), human, recombinant
Artikelnummer: CSB-EP013627HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-490aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL ALAQDHSMDI...
| Schlagworte: | MDMX, MDM4, Protein Mdmx, Protein Mdm4, Double minute 4 protein, p53-binding protein Mdm4, Mdm2-like p53-binding protein,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 59.0 kD |
ab 213,00 €
Anti-MDM4
Artikelnummer: CSB-PA010135.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-MDM4, Anti-MDMX, Anti-Protein Mdm4, Anti-Protein Mdmx, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Anti-Phospho-MDM4 (Ser367)
Artikelnummer: CSB-PA975669.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-MDM4, Anti-phospho-MDMX, Anti-phospho-Protein Mdm4, Anti-phospho-Protein Mdmx, Anti-phospho-Double minute 4... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
330,00 €
Anti-HdmX/MDM4 Recombinant Monoclonal
Artikelnummer: A700-000
Protein function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium]
| Schlagworte: | Anti-MDMX, Anti-MDM4, Anti-Protein Mdmx, Anti-Protein Mdm4, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Anwendung: | WB, IP, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 172,00 €
Anti-MDM4
Artikelnummer: G-CAB1747.100
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
448,00 €
Anti-HdmX/MDM4
Artikelnummer: A303-870A
Protein function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium]
| Schlagworte: | Anti-MDMX, Anti-MDM4, Anti-Protein Mdmx, Anti-Protein Mdm4, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Anwendung: | WB, IP |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-MDM4 / MDMX
Artikelnummer: NSJ-R31805
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein...
| Schlagworte: | Anti-MDMX, Anti-MDM4, Anti-Protein Mdmx, Anti-Protein Mdm4, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
755,00 €
NSC-207895
Artikelnummer: LKT-N7209.1
NSC-207895 is a benzofuroxan derivative that inhibits MDMX. NSC-207895 exhibits anticancer activity, increasing Bax, PIG3, and PUMA and inducing apoptosis in breast cancer cells.
| Schlagworte: | NSC207895 |
| Anwendung: | MDMX inhibitor |
| CAS | 58131-57-0 |
| MW: | 279.25 D |
ab 137,00 €