Zu "K09592" wurden 105 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Roxadustat
Artikelnummer: Cay15294-10
Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.Formal...
| Schlagworte: | ASP1517, Roxadustat, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine |
| Anwendung: | Presumed HIF-PH inhibitor |
| CAS | 808118-40-3 |
| MW: | 352.4 D |
ab 44,00 €
Vadadustat
Artikelnummer: TGM-T4651-25mg
Description: Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. Target: HIF, HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1. References: Pergola PE, et al. Vadadustat, a novel oral HIF...
| Schlagworte: | PG-1016548, AKB-6548 |
| Anwendung: | Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH) |
| CAS | 1000025-07-9 |
| MW: | 306.7 D |
ab 42,00 €
TP0463518
Artikelnummer: TGM-T5392-5mg
Description: TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O. References: Kato S, et al. TP0463518, a novel inhibitor for...
| Anwendung: | Pan HIF-PH inhibitor |
| CAS | 1558021-37-6 |
| MW: | 431.83 D |
ab 46,00 €
Daprodustat
Artikelnummer: TGM-T3197-10mg
Description: Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor. Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O. References: Brigandi RA, et al. Am J Kidney Dis. 2016. doi: 10.1053/j.ajkd.2015.11. 021.
| Schlagworte: | GSK1278863 |
| Anwendung: | Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH) |
| CAS | 960539-70-2 |
| MW: | 393.43 D |
ab 49,00 €
Molidustat
Artikelnummer: TGM-T2652-1mg
Description: Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells. Target: HIF/HIF Prolyl-Hydroxylase. Smiles: O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1. References: Flamme I, et...
| Schlagworte: | BAY 85-3934 |
| Anwendung: | Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH) |
| CAS | 1154028-82-6 |
| MW: | 314.3 D |
ab 45,00 €
MK-8617
Artikelnummer: TGM-T4106-100mg
Description: MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: COc1ccc(cc1)C(NC(=O)c1cnc([nH]c1=O)-c1cccnn1)c1ccc(OC)cc1. References: John S. Debenham, et al. J Med Chem. 2016, 59 (24):11039-11049.
| Schlagworte: | MK8617 |
| Anwendung: | Pan HIF-PH inhibitor |
| CAS | 1187990-87-9 |
| MW: | 443.45 D |
ab 31,00 €
Roxadustat-d5
Artikelnummer: TGM-T69966-1mg
Description: Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH, IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH...
| Anwendung: | GC-MS, LC-MS internal standard, quantification, HIF-PH inhibitor |
| CAS | 2043026-13-5 |
| MW: | 357.37 D |
1.140,00 €
EGLN1 Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01280-100ug
Description: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal,...
| Schlagworte: | HIF-prolyl hydroxylase 2, PHD2, SM-20, HIF-PH2, Egl nine homolog 1, C1orf12, EGLN1, HPH-2 |
| MW: | 35.3 kD |
ab 281,00 €
IOX2
Artikelnummer: TGM-T1823-10mg
Description: IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD), active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O. References: Murray...
| Schlagworte: | IOX 2, JICL38 |
| Anwendung: | PHD2 inhibitor |
| CAS | 931398-72-0 |
| MW: | 352.34 D |
ab 34,00 €
Prolyl Hydroxylase inhibitor 1
Artikelnummer: TGM-T12547-100mg
Description: Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM). Target: Others. Smiles: OC1=CC(=CN=C1C(NCC(O)=O)=O)C2=CN(CCCC3=CC=C(Cl)C=C3)N=N2. References: Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1...
| Anwendung: | Hypoxia-inducible factor prolyl hydroxylase (HPH) inhibitor |
| CAS | 2205125-60-4 |
| MW: | 415.83 D |
ab 1.820,00 €
Enarodustat
Artikelnummer: TGM-T15219-100mg
Description: Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 µM) and has the potential for renal anemia treatment. Target: HIF/HIF Prolyl-Hydroxylase, Others. Smiles: OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12. References: Ogoshi Y, et al. Discovery of JTZ-951: A HIF...
| Schlagworte: | JTZ-951 |
| Anwendung: | Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH) |
| CAS | 1262132-81-9 |
| MW: | 340.33 D |
ab 34,00 €
Egl nine homolog 2 (EGLN2), partial, human, recombinant
Artikelnummer: CSB-EP007482HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 283-407aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MVACYPGNGL GYVRHVDNPH GDGRCITCIY YLNQNWDVKV HGGLLQIFPE GRPVVANIEP LFDRLLIFWS DRRNPHEVKP AYATRYAITV WYFDAKERAA AKDKYQLASG QKGVQVPVSQ PPTPT. Purity: Greater...
| Schlagworte: | PHD1, HPH-3, HPH-1, EIT-6, HIF-PH1, Egl nine homolog 2, Estrogen-induced tag 6, Prolyl hydroxylase EGLN2, HIF-prolyl... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 18.1 kD |
ab 219,00 €