Zu "K09095" wurden 55 Artikel gefunden!
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ZG-2033
Artikelnummer: Cay41672-1
ZG-2033 is an agonist of hypoxia-inducible factor 2alpha (HIF-2alpha). It induces HIF-2alpha transcriptional activity in a reporter assay using 786-O cells expressing HIF-2alpha (EC50 = 0.49 µM). ZG-2033 (10 or 50 µM), in combination with the inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and...
| Schlagworte: | N-(3,5-dimethoxyphenyl)-1,2-benzisothiazol-3-amine |
| Anwendung: | HIF-2alpha (EPAS1) agonist |
| CAS | 2685739-28-8 |
| MW: | 286.3 D |
ab 67,00 €
M1001
Artikelnummer: TGM-T7802-100mg
Description: M1001 is a HIF-2alpha agonist. Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: O=S1(=O)N=C(Nc2ccccc2N2CCCC2)c2ccccc12. References: Bidirectional Modulation of HIF-2 Activity through Chemical Ligands[C]// 0.
| Anwendung: | HIF-2alpha (EPAS1) modulator |
| CAS | 874590-32-6 |
| MW: | 327.4 D |
ab 55,00 €
PT-2385
Artikelnummer: TGM-T7848-100mg
Description: PT-2385 is a selective inhibitor of HIF-2alpha with a dissociation constant (Kd) of less than 50 nM (Kd<50 nM). Target: HIF, HIF/HIF Prolyl-Hydroxylase. Smiles: CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12. References: Eli Wallace, Ph.D. PT2385: HIF-2alpha Antagonist for the Treatment of...
| Anwendung: | HIF-2alpha inhibitor |
| CAS | 1672665-49-4 |
| MW: | 383.34 D |
ab 60,00 €
TC-S 7009
Artikelnummer: TGM-T17009-100mg
Description: TC-S 7009 is a potent and selective HIF-2alpha inhibitor (Kd: 81 nM) with significantly higher affinity for HIF-2alpha than HIF-1alpha (Kd >> 5µM). TC-S 7009 disrupts HIF-2alpha heterodimerization, reduces HIF-2alpha target gene expression, and diminishes DNA binding activity. Target: HIF. Smiles:...
| Anwendung: | EPAS-1 PAS-B domain heterodimerization inhibitor |
| CAS | 1422955-31-4 |
| MW: | 308.65 D |
ab 63,00 €
Belzutifan
Artikelnummer: TGM-T16679-100mg
Description: Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2alpha inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2alpha inhibitor, increases potency and improves pharmacokinetic profile. Target: HIF....
| Schlagworte: | MK-6482, PT2977 |
| Anwendung: | Targets hypoxia-inducible factor 2 alpha (HIF2A, EPAS1) |
| CAS | 1672668-24-4 |
| MW: | 383.34 D |
ab 63,00 €
PT2385
Artikelnummer: Cay21325-10
PT2385 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha, IC50 = 12 nM). It inhibits HIF-2alpha-induced production of Vegfa mRNA and reduces tumor volume in a 786-O renal cell carcinoma mouse xenograft model when administered at a dose of 10 mg/kg. PT2385 (20 mg/kg) also inhibits the transcription of...
| Schlagworte: | 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-benzonitrile |
| Anwendung: | HIF-2alpha inhibitor |
| CAS | 1672665-49-4 |
| MW: | 383.3 D |
ab 136,00 €
Human EPAS1 / HIF-2 alpha ELISA Kit
Artikelnummer: ARG83442.96
Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems...
| Schlagworte: | HLF, HLF, EPAS1, EPAS-1, EPAS-1, BHLHE73, bHLHe73, bHLHe73, HIF2-alpha, HIF2-alpha, HIF-2-alpha, HIF-2-alpha,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.085,00 €
Rat EPAS1 / HIF-2 alpha ELISA Kit
Artikelnummer: ARG83448.96
Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems...
| Schlagworte: | HLF, HLF, EPAS1, EPAS-1, EPAS-1, BHLHE73, bHLHe73, bHLHe73, HIF2-alpha, HIF2-alpha, HIF-2-alpha, HIF-2-alpha,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
1.085,00 €
Anti-EPAS1
Artikelnummer: CSB-PA005478.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-HLF, Anti-EPAS1, Anti-EPAS-1, Anti-bHLHe73, Anti-BHLHE73, Anti-HIF2-alpha, Anti-HIF-2-alpha, Anti-HIF-1-alpha-like... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-EPAS1
Artikelnummer: CSB-PA244646.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-HLF, Anti-EPAS1, Anti-EPAS-1, Anti-bHLHe73, Anti-BHLHE73, Anti-HIF2-alpha, Anti-HIF-2-alpha, Anti-HIF-1-alpha-like... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Anti-HIF2-alpha Recombinant Monoclonal
Artikelnummer: A700-003
Protein function: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of...
| Schlagworte: | Anti-HLF, Anti-EPAS1, Anti-EPAS-1, Anti-BHLHE73, Anti-bHLHe73, Anti-HIF2-alpha, Anti-HIF-2-alpha, Anti-HIF-1-alpha-like... |
| Anwendung: | WB, IP, IHC, ICC, ICC-IF, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 185,00 €
HIF-2alpha Antagonist 2
Artikelnummer: Cay16971-5
HIF-2alpha antagonist 2 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) PAS-B domain heterodimerization. It binds to the HIF-2alpha PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at...
| Schlagworte: | N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine |
| Anwendung: | EPAS-1 PAS-B domain heterodimerization inhibitor |
| CAS | 1422955-31-4 |
| MW: | 308.7 D |
ab 53,00 €