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Zu "K08871" wurden 60 Artikel gefunden!
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Artikelnummer: A302-583A
Protein function: May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. [The UniProt Consortium]
Schlagworte: | Anti-BRD2, Anti-O27.1.1, Anti-KIAA9001, Anti-Bromodomain-containing protein 2, Anti-Really interesting new gene 3 protein |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Artikelnummer: Cay38777-5
RVX-297 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2). It inhibits BD2 in bromodomain-containing protein 2 (BRD2), BRD3, and BRD4, (IC50s = 0.08, 0.05, and 0.02 µM, respectively) and is selective for BD2 over BD1 (IC50s = 3.76, 2.34, and 1.16 µM for BRD2, BRD3,...
Schlagworte: | 2-[3,5-dimethyl-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5,7-dimethoxy-4(3H)-quinazolinone |
Anwendung: | BD2 bromodomain inhibitor |
CAS | 1044871-04-6 |
MW: | 423.5 D |
ab 101,00 €
Artikelnummer: BPS-27402
(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains. (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.
Schlagworte: | BET inhibitor, Bromodomain inhibitor, |
Anwendung: | BRD inhibitor |
MW: | 456.99 D |
202,00 €
Artikelnummer: Cay15947-1
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an...
Schlagworte: | (-)-OTX015, HY-15743,... |
Anwendung: | BRD2 / BRD3 / BRD4 inhibitor |
CAS | 202590-98-5 |
MW: | 492 D |
ab 66,00 €
Artikelnummer: LKT-J6400.1
JQ-1 is a triazolothienodiazepine compound that inhibits the BET bromodomain (BRD) family of proteins. Although it is a diazepine-like compound, JQ-1 exhibits no sedative or anxiolytic efficacy. JQ-1 was initially in development as a non-hormonal male contraceptive, inhibiting bromodomain testis-specific protein...
Anwendung: | Bromodomain Inhibitor |
CAS | 1268524-70-4 |
MW: | 456.99 D |
ab 112,00 €
Artikelnummer: A302-582A
Protein function: May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. [The UniProt Consortium]
Schlagworte: | Anti-BRD2, Anti-O27.1.1, Anti-KIAA9001, Anti-Bromodomain-containing protein 2, Anti-Really interesting new gene 3 protein |
Anwendung: | WB, IP, ICC-IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay11181-1
The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET151 is an...
Schlagworte: | GSK1210151A, 7,3,5-dimethyl-4-isoxazolyl-1,3-dihydro-8-methoxy-1-[1R-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one |
Anwendung: | pan-BET family inhibitor |
CAS | 1300031-49-5 |
MW: | 415.5 D |
ab 48,00 €
Artikelnummer: A300-204A
Protein function: May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. [The UniProt Consortium]
Schlagworte: | Anti-BRD2, Anti-O27.1.1, Anti-KIAA9001, Anti-Bromodomain-containing protein 2, Anti-Really interesting new gene 3 protein |
Anwendung: | WB, IP |
Wirt: | Goat |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: A700-008
Protein function: May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. [The UniProt Consortium]
Schlagworte: | Anti-BRD2, Anti-O27.1.1, Anti-KIAA9001, Anti-Bromodomain-containing protein 2, Anti-Really interesting new gene 3 protein |
Anwendung: | WB, IP, FC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 172,00 €
Artikelnummer: BPS-30021
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Schlagworte: | BRD2, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Really interesting new gene 3 protein, |
Anwendung: | Enzyme kinetics, dephosphorylation, inhibitor screening |
MW: | 95 kD |
481,00 €
Artikelnummer: Cay11155-5
Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples...
Schlagworte: | PF-06405761, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
Anwendung: | Bromodomain inhibitor |
CAS | 1403764-72-6 |
MW: | 347.4 D |
ab 52,00 €
Artikelnummer: BPS-27629-1
I-BET151(GSK1210151A) is a BET bromodomain inhibitor. I-BET151 displays potent binding affinity to BRD2, BRD3 and BRD4 with Kd of 0.02-0.1 µM. I-BET151 (0.5 or 5 µM) inhibits the binding of BETs (BRD2, BRD3, BRD4, and BRD9) but not the binding of 23 other bromodomain proteins. I-BET151 also blocks recruitment of BET...
Schlagworte: | I-BET151, GSK1210151A,... |
Anwendung: | BET bromodomain inhibitor |
MW: | 415.4 D |
ab 402,00 €