Zu "K08863" wurden 22 Artikel gefunden!
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Ocifisertib(CFI-400945 free base)
Artikelnummer: TGM-T7384-100mg
Description: CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4, Ki value of 0.26 nM). Target: PLK. Smiles: O=C1[C@]2([C@@H](C2)C=3C=C4C(=CC3)C(/C=C/C5=CC=C(CN6C[C@@H](C)O[C@@H](C)C6)C=C5)=NN4)C=7C(N1)=CC=C(OC)C7. References: Mason J , Lin D C , Wei X , et al. Functional...
| Anwendung: | PLK4 inhibitor |
| CAS | 1338806-73-7 |
| MW: | 534.65 D |
ab 38,00 €
BBT594
Artikelnummer: TGM-T7418-100mg
Description: BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer. Target: c-RET. Smiles: CN1CCN(Cc2ccc(NC(=O)N3CCc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1. References: Zhang Q , Shi C , Han L , et al. Inhibition of mTORC1/C2 signaling improves anti-leukemia...
| Schlagworte: | NVP-BBT594 |
| Anwendung: | Potent PLK4 inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.58 D |
ab 37,00 €
Centrinone
Artikelnummer: TGM-T14927-100mg
Description: Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4, Ki:0.16 nM). Target: Aurora Kinase, PLK. Smiles: COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCOCC1. References: Wong YL. et al. Cell biology. Reversible centriole depletion with an...
| Schlagworte: | LCR-263 |
| Anwendung: | Plk4 inhibitor |
| CAS | 1798871-30-3 |
| MW: | 633.65 D |
ab 55,00 €
PLK4, GST-tag
Artikelnummer: BPS-40236
Human polo-like kinase 4 (PLK4), also known as serine/threonine protein kinase 18 (STK18), SAK, GenBank Accession No. NM_014264, a.a. 1-836 with an N-terminal GST-tag, expressed in a baculovirus-infected Sf9 cell expression system. MW = 140 kDa.
| Schlagworte: | SAK, PLK-4, Polo-like kinase 4, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase Sak,... |
| Anwendung: | Studying enzyme kinetics, small molecule inhibitor screening |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 140 kD |
862,00 €
Centrinone
Artikelnummer: Cay24684-1
Centrinone is an inhibitor of polo-like kinase 4 (Plk4, Ki = 0.16 nM). It is greater than 1,100- and 2,800-fold selective for Plk4 over Aurora A and Aurora B kinases, respectively, and a panel of 442 kinases at 100 nM. Centrinone (125 nM) depletes centrosomes and induces apoptosis in HeLa cells.Formal Name:...
| Schlagworte: | LCR-263,... |
| Anwendung: | Plk4 inhibitor |
| CAS | 1798871-30-3 |
| MW: | 633.6 D |
ab 44,00 €
-30 %
Rabattaktion
Anti-Sak / STK18 / PLK4, N-terminal
Artikelnummer: ARG63489.100
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, EC=2.7.11.21, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
736,00 €
515,20 €
CFI-400437
Artikelnummer: SYN-1207-M001
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft...
| Schlagworte: | (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one... |
| Anwendung: | Potent PLK4 inhibitor |
| MW: | 565.5 D |
ab 250,00 €
-30 %
Rabattaktion
Anti-PLK4
Artikelnummer: ARG40139.100
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
624,00 €
436,80 €
Anti-PLK4
Artikelnummer: E-AB-18272.120
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Anti-PLK4
Artikelnummer: ATA-HPA017327.100
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-PLK4
Artikelnummer: ATA-HPA043198.100
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-PLK4
Artikelnummer: ATA-HPA035026.100
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...
| Schlagworte: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €