Zu "K08860" wurden 72 Artikel gefunden!
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Anti-EIF2AK3
Artikelnummer: ABS-KC-3246.100
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as...
| Schlagworte: | Anti-Eukaryotic translation initiation factor 2-alpha kinase 3, Anti-PRKR-like endoplasmic reticulum kinase,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
PERK-IN-4
Artikelnummer: TGM-T38732-100mg
Description: PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM, used in the study of cancer and neurological disorders. Target: PERK. Smiles: Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cc(F)cc(c2)C(F)(F)F)c2c(N)ncnc12. References: Axten JM, et al. Discovery of...
| Anwendung: | EIF2AK3 inhibitor |
| CAS | 1337531-89-1 |
| MW: | 469.43 D |
ab 60,00 €
ISRIB (trans-isomer)
Artikelnummer: TGM-T6183-100mg
Description: ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2alpha. Target: Apoptosis, Autophagy, PERK. Smiles: Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1. References: Sidrauski C, et al. Elife....
| Schlagworte: | trans-ISRIB, trans-isomer, ISRIB, ISRIB trans-isomer |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1597403-47-8 |
| MW: | 451.34 D |
ab 31,00 €
GSK2606414
Artikelnummer: TGM-T2614-10mg
Description: GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM). Target: Apoptosis, PERK, Autophagy. Smiles: NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4. References: Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.
| Anwendung: | EIF2AK3?/ PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451.44 D |
ab 60,00 €
CCT020312
Artikelnummer: TGM-T14902-100mg
Description: CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A. Target: PERK. Smiles: CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O. References: Stockwell SR, et al.Mechanism-based screen for G1/S...
| Anwendung: | EIF2AK3 activator |
| CAS | 324759-76-4 |
| MW: | 650.4 D |
ab 57,00 €
GSK2606414
Artikelnummer: Cay17376-1
GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC50 value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the...
| Schlagworte: | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]-ethanone |
| Anwendung: | EIF2AK3?/ PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451.4 D |
ab 49,00 €
Anti-EIF2AK3
Artikelnummer: CSB-PA003739.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
Anti-Phospho-EIF2AK3 (T981)
Artikelnummer: CSB-PA000746.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-PEK, Anti-phospho-HsPEK, Anti-phospho-EIF2AK3, EC=2.7.11.1, Anti-phospho-Pancreatic eIF2-alpha kinase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-EIF2AK3
Artikelnummer: CSB-PA071225.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: EIF2AK3. Antigen Species: Human
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-Phospho-EIF2AK3 (Thr981)
Artikelnummer: CSB-PA072558.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-PEK, Anti-phospho-HsPEK, Anti-phospho-EIF2AK3, EC=2.7.11.1, Anti-phospho-Pancreatic eIF2-alpha kinase,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
340,00 €
Anti-EIF2AK3
Artikelnummer: CSB-PA154507.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: EIF2AK3. Antigen Species: Human
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-EIF2AK3
Artikelnummer: CSB-PA590642.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €