Zu "K08852" wurden 67 Artikel gefunden!
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APY29
Artikelnummer: TGM-T3654-100mg
Description: APY29 is an allosteric modulator of IRE1alpha, inhibits IRE1alpha autophosphorylation (IC50 = 280 nM) and activates IRE1alpha RNase activity. Target: IRE1. Smiles: C1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1. References: Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al....
| Anwendung: | IRE1alpha modulator |
| CAS | 1216665-49-4 |
| MW: | 332.36 D |
ab 36,00 €
IXA4
Artikelnummer: TGM-T9349-100mg
Description: IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function. Target: IRE1. Smiles: CN(CCOc1ccc(C)cc1)C(=O)Cn1cc(NC(=O)CCOc2ccccc2)cn1. References: Grandjean JMD, et al. Pharmacologic...
| Anwendung: | IRE1 activator |
| CAS | 1185329-96-7 |
| MW: | 436.5 D |
ab 34,00 €
IRE1 Protein, Human, Recombinant (aa 465-977)
Artikelnummer: TGM-TMPY-04753-100ug
Description: IRE1 Protein, Human, Recombinant (aa 465-977) is expressed in Baculovirus insect cells. The predicted molecular weight is 58.3 kDa and the accession number is O75460-1.
| Schlagworte: | hIRE1p, IRE1P, endoplasmic reticulum to nucleus signaling 1, IRE1, IRE1a |
| MW: | 58.3 kD |
ab 313,00 €
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
Artikelnummer: TGM-TMPY-04413-100ug
Description: IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 86 kDa and the accession number is O75460-1.
| Schlagworte: | hIRE1p, endoplasmic reticulum to nucleus signaling 1, IRE1, IRE1a, IRE1P |
| MW: | 86 kD |
ab 313,00 €
MKC3946
Artikelnummer: TGM-TQ0101-100mg
Description: MKC3946 is an effective and soluble IRE1alpha inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. Target: IRE1. Smiles: CN1CCN(CC1)C(=O)c1ccc(s1)-c1ccc2c(C=O)c(O)ccc2c1. References: Sun H, et al. Inhibition of IRE1alpha-driven pro-survival pathways is a promising...
| Anwendung: | IRE1alpha inhibitor |
| CAS | 1093119-54-0 |
| MW: | 380.46 D |
ab 60,00 €
KIRA6
Artikelnummer: TGM-TQ0076-100mg
Description: KIRA6 is an effective inhibitor of IRE1alpha RNase kinase (IC50: 0.6 µM). It can trigger an apoptotic response. Target: IRE1. Smiles: CC(C)(C)c1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c3ccccc23)c2c(N)nccn12. References: Mahameed M,et al. The unfolded protein response modulators GSK2606414 and KIRA6 are...
| Anwendung: | ATP-competitive IRE1alpha kinase inhibiting RNase attenuator |
| CAS | 1589527-65-0 |
| MW: | 518.53 D |
ab 39,00 €
STF-083010
Artikelnummer: TGM-T6681-100mg
Description: STF-083010 is a selective inhibitor of the IRE1alpha endonuclease. Target: IRE1. Smiles: O=C1C=Cc2ccccc2\C1=C\NS(=O)(=O)c1cccs1. References: Papandreou l, et al. Blood. 2011, 117(4), 1311-1314.
| Schlagworte: | STF083010 |
| Anwendung: | ERN1 endonuclease inhibitor |
| CAS | 307543-71-1 |
| MW: | 317.38 D |
ab 47,00 €
MKC8866
Artikelnummer: TGM-T15594-100mg
Description: MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 µM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth. Target: IRE1. Smiles:...
| Anwendung: | IRE1alpha RNase activity inhibitor |
| CAS | 1338934-59-0 |
| MW: | 361.35 D |
ab 78,00 €
GSK2850163
Artikelnummer: Cay40917-10
GSK2850163 is an inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha, IC50s = 0.2 and 0.02 µM for RNase and kinase activity, respectively). It is selective for IRE1alpha over Ron and FGFR1 (IC50s = 4.4 and 17 µM), as well as a panel of 282 kinases at 10 µM. GSK2850163 (8 µM) inhibits endoplasmic reticulum (ER)...
| Schlagworte: | GSK163, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5R]decane-7-carboxamide |
| Anwendung: | IRE1alpha kinase / RNase inhibitor |
| CAS | 2121989-91-9 |
| MW: | 446.4 D |
ab 101,00 €
KIRA6
Artikelnummer: Cay19151-1
The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1alpha RNase, whose activity upregulates proteins that enhance ER protein...
| Schlagworte: | IRE1 Inhibitor IV, IRE1alpha Kinase Inhibiting RNase Attenuator 6,... |
| Anwendung: | ATP-competitive IRE1alpha kinase inhibiting RNase attenuator |
| CAS | 1589527-65-0 |
| MW: | 518.5 D |
ab 50,00 €
4µ8C
Artikelnummer: Cay22110-5
4µ8C is an inhibitor of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. 4µ8C inhibits IRE1alpha splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50...
| Schlagworte: | IRE1 Inhibitor III, 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
| CAS | 14003-96-4 |
| MW: | 204.2 D |
ab 50,00 €
STF-083010
Artikelnummer: Cay17370-5
STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Cay-10522), an ER stress inducer....
| Schlagworte: | IRE1 Inhibitor I, N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Anwendung: | ERN1 endonuclease inhibitor |
| CAS | 307543-71-1 |
| MW: | 317.4 D |
ab 60,00 €