Zu "K08844" wurden 89 Artikel gefunden!
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CZC-54252
Artikelnummer: TGM-T2022-1mg
Description: CZC-54252 is a potent inhibitor of LRRK2. Target: LRRK2. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1. References: Liu F, et al. J Pharmacol Exp Ther, 2008, 327(3), 827-839.
| Schlagworte: | CZC54252, CZC 54252 |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1191911-27-9 |
| MW: | 504.99 D |
ab 33,00 €
GNE0877
Artikelnummer: TGM-T6031-100mg
Description: GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). Target: LRRK2. Smiles: CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F. References: Estrada AA, et al. J Med Chem. 2014, 57(3), 921-936.
| Schlagworte: | GNE-0877, GNE 0877 |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1374828-69-9 |
| MW: | 339.32 D |
ab 40,00 €
JH-II-127
Artikelnummer: TGM-T7155-100mg
Description: JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively. Target: LRRK2. Smiles: CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12. References: Discovery of a...
| Anwendung: | LRRK2 inhibitor |
| CAS | 1700693-08-8 |
| MW: | 416.86 D |
ab 45,00 €
GNE-7915
Artikelnummer: TGM-T1945-100mg
Description: GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor. Target: LRRK2. Smiles: CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F. References: Estrada AA, et al. J Med Chem. 2012, 55(22), 9416-9433.
| Schlagworte: | GNE7915 |
| Anwendung: | LRRK2 kinase inhibitor |
| CAS | 1351761-44-8 |
| MW: | 443.4 D |
ab 40,00 €
GNE-9605
Artikelnummer: TGM-T1770-100mg
Description: GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM). Target: LRRK2. Smiles: CNc1nc(Nc2cnn([C@H]3CCN(C[C@@H]3F)C3COC3)c2Cl)ncc1C(F)(F)F. References: Estrada AA , et al. J Med Chem. 2014, 57(3), 921-936.
| Anwendung: | LRRK2 inhibitor |
| CAS | 1536200-31-3 |
| MW: | 449.83 D |
ab 33,00 €
LRRK2 inhibitor 1
Artikelnummer: TGM-T11878-100mg
Description: LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM. Target: CDK, LRRK2. Smiles: CCOc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]ccc12. References: Ding X, et al. Discovery of...
| Anwendung: | LRRK2 inhibitor |
| CAS | 1802525-61-6 |
| MW: | 397.43 D |
ab 67,00 €
MLi-2
Artikelnummer: TGM-T16115-100mg
Description: MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM),...
| Anwendung: | LRRK2 inhibitor |
| CAS | 1627091-47-7 |
| MW: | 379.46 D |
ab 60,00 €
PF-06447475
Artikelnummer: TGM-T2050-100mg
Description: PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively. Target: LRRK2. Smiles: N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12. References: Henderson JL, et al. J Med Chem. 2015, 58(1), 419-432.
| Anwendung: | LRRK2 inhibitor |
| CAS | 1527473-33-1 |
| MW: | 305.33 D |
ab 43,00 €
Leucine-rich repeat serine/threonine-protein kinase 2...
Artikelnummer: CSB-EP722493HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 904-1450aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: VKKKSNSISV GEFYRDAVLQ RCSPNLQRHS NSLGPIFDHE DLLKRKRKIL SSDDSLRSSK LQSHMRHSDS ISSLASEREY ITSLDLSANE LRDIDALSQK CCISVHLEHL EKLELHQNAL TSFPQQLCET LKSLTHLDLH...
| Schlagworte: | LRRK2, PARK8, Dardarin, Leucine-rich repeat serine/threonine-protein kinase 2, Recombinant Human Leucine-rich repeat... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 69.3 kD |
ab 292,00 €
Anti-LRRK2
Artikelnummer: CSB-PA444926.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: LRRK2. Antigen Species: Human
| Schlagworte: | Anti-PARK8, Anti-LRRK2, Anti-Dardarin, Anti-Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-LRRK2
Artikelnummer: CSB-PA902150.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: LRRK2. Antigen Species: Human
| Schlagworte: | Anti-PARK8, Anti-LRRK2, Anti-Dardarin, Anti-Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
GSK2578215A
Artikelnummer: Cay14603-5
GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC50 = 10.1 nM). It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type and G2019S LRRK2 in mouse spleen and...
| Schlagworte: | 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-benzamide |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1285515-21-0 |
| MW: | 399.4 D |
ab 78,00 €