Zu "K08557" wurden 329 Artikel gefunden!
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AR (human) Reporter Assay Kit
Artikelnummer: IB-IB03001
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO's reporter cells include the luciferase...
| Schlagworte: | AR, DHTR, Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.507,00 €
NEU
Anti-AR
Artikelnummer: ABS-KC-2488.100
Protein function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits...
| Schlagworte: | Anti-Androgen receptor, Anti-Dihydrotestosterone receptor, Anti-Nuclear receptor subfamily 3 group C member 4, AR Antibody |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Masofaniten
Artikelnummer: Cay41670-1
Masofaniten is an androgen receptor N-terminal transactivation domain inhibitor (ARTADI). It binds to the tryptophan residues in positions 397 (W397) and W433 in the AR TAD.Formal Name: N-[4-[[4-[1-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]-1-methylethyl]phenoxy]methyl]-2-pyrimidinyl]-methanesulfonamide. CAS...
| Schlagworte: | EPI-7386,... |
| Anwendung: | Androgen receptor N-terminal transactivation domain inhibitor (ARTADI) |
| CAS | 2416716-62-4 |
| MW: | 535.4 D |
ab 146,00 €
(R)-SKBG-1
Artikelnummer: Cay42091-1
(R)-SKBG-1 is a degrader of mRNA encoding the androgen receptor (AR). It decreases mRNA levels of AR and AR splice variant seven (AR-V7) and protein levels of AR and AR-V7 in 22Rv1 prostate cancer cells when used at a concentration of 20 µM. (R)-SKBG-1 (20 µM) reduces protein levels of AR and AR-V7 in wild-type...
| Schlagworte: | (2R)-4-(2-chloroacetyl)-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide |
| Anwendung: | Androgen receptor (AR) mRNA degrader |
| CAS | 2955634-67-8 |
| MW: | 496 D |
ab 272,00 €
(S)-SKBG-1
Artikelnummer: Cay42092-1
(S)-SKBG-1 is an inactive enantiomer of (R)-SKBG-1 (Cay-42091), a degrader of mRNA encoding the androgen receptor (AR).Formal Name: (2S)-4-(2-chloroacetyl)-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide. CAS Number: 2955618-24-1. Molecular Formula: C22H26ClN3O6S. Formula Weight:...
| Schlagworte: | (2S)-4-(2-chloroacetyl)-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide |
| Anwendung: | Inactive enantiomer |
| CAS | 2955618-24-1 |
| MW: | 496 D |
ab 239,00 €
5alpha-dihydro-11-keto Testosterone-d3
Artikelnummer: Cay9002761-1
5alpha-dihydro-11-keto Testosterone-d3 is intended for use as an internal standard for the quantification of 5alpha-dihydro-11-keto testosterone (Cay-20200) by GC- or LC-MS. 5alpha-dihydro-11-keto Testosterone is a metabolite of 11beta-hydroxyandrostenedione and 11beta-hydroxytestosterone that has been shown to act...
| Schlagworte: | 11-keto Dihydrotestosterone-d3, 17beta-hydroxy-5alpha-Androstane-3,11-dione-d3, 5alpha-Androstane-3,11-dione-17beta-ol-d3,... |
| Anwendung: | Analytical reference standard, GC-MS, LC-MS internal standard, quantification, metabolite, AR agonist |
| MW: | 307.4 D |
ab 100,00 €
Darolutamide
Artikelnummer: TGM-T6915-25mg
Description: Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM). Target: Androgen Receptor. Smiles: C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1)NC(=O)c1cc([nH]n1)C(C)O. References: Moilanen AM, et al. Sci Rep. 2015, 5:12007. doi: 10.1038/srep12007.
| Schlagworte: | ODM-201, BAY-1841788 |
| Anwendung: | Targets androgen receptor (AR, NR3C4) |
| CAS | 1297538-32-9 |
| MW: | 398.85 D |
ab 45,00 €
Topterone
Artikelnummer: TGM-T13187-1mg
Description: Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters. Target: Androgen Receptor. Smiles:...
| Schlagworte: | Win 17665 |
| Anwendung: | Targets androgen receptor (AR, NR3C4) |
| CAS | 60607-35-4 |
| MW: | 330.5 D |
ab 699,00 €
S-23
Artikelnummer: TGM-T20789-10mg
Description: S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. Target: Androgen Receptor....
| Schlagworte: | S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide |
| Anwendung: | Selective androgen receptor modulator (SARM) |
| CAS | 1010396-29-8 |
| MW: | 416.75 D |
ab 40,00 €