Zu "K08550" wurden 398 Artikel gefunden!
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Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 77,00 €
NEU
LSZ-102
Artikelnummer: Cay41834-1
LSZ-102 is an estrogen receptor alpha (ERalpha) degrader (IC50 = 0.2 nM). It reduces 17beta-estradiol-induced transcription in a reporter assay using MCF-7 breast cancer cells expressing ERalpha (IC50 = 6 nM). LSZ-102 decreases the proliferation of MCF-7 cells (IC50 = 1.7 nM). In vivo, LSZ-102 (20 mg/kg per day)...
| Schlagworte: | 3-[4-[[2E-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid |
| Anwendung: | ERalpha degrader |
| CAS | 2135600-76-7 |
| MW: | 470.5 D |
ab 62,00 €
NEU
Raloxifene
Artikelnummer: Cay41845-1
Raloxifene (Cay-41845) is an analytical reference standard categorized as a selective estrogen receptor modulator (SERM). It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for analytical forensic applications. This product is also available as a general...
| Schlagworte: | Keoxifene, LY156758, NSC 747974,... |
| Anwendung: | Analytical reference standard, selective estrogen receptor modulator (SERM) |
| CAS | 84449-90-1 |
| MW: | 473.6 D |
ab 150,00 €
17-Epiestriol
Artikelnummer: TGM-T36913-5mg
Description: 17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16alpha-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor alpha (ERalpha) and ERbeta with relative binding affinities of 29 and 80 compared with 17beta-estradiol .2. Target:...
| Anwendung: | Estrone metabolite |
| CAS | 1228-72-4 |
| MW: | 288.38 D |
1.275,00 €
AZD9496
Artikelnummer: TGM-T3975-100mg
Description: AZD9496 is an orally available selective estrogen receptor(ERalpha) antagonist, with potential antineoplastic activity. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: C(C(C)(C)F)N1[C@@H](C2=C(C=3C(N2)=CC=CC3)C[C@H]1C)C4=C(F)C=C(/C=C/C(O)=O)C=C4F. References: Weir HM, et al....
| Anwendung: | Estrogen receptor downregulator & antagonist |
| CAS | 1639042-08-2 |
| MW: | 442.47 D |
ab 51,00 €
Lasofoxifene
Artikelnummer: TGM-T62119-10mg
Description: Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic. Target: Others. Smiles: OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1
| Anwendung: | SERM |
| CAS | 180916-16-9 |
| MW: | 413.55 D |
ab 289,00 €
H3B-5942
Artikelnummer: TGM-T5633-100mg
Description: H3B-5942 belongs to a class of ERalpha antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CC\C(=C(\c1ccc(OCCNC\C=C\C(=O)N(C)C)cc1)c1ccc2[nH]ncc2c1)c1ccccc1. References: Discovery of Selective...
| Anwendung: | Selective estrogen receptor covalent antagonist (SERCA) |
| CAS | 2052128-15-9 |
| MW: | 494.63 D |
ab 77,00 €
Palazestrant
Artikelnummer: TGM-T72945-10mg
Description: Palazestrant (OP-1250) is an orally available and highly potent estrogen receptor antagonist and selective ER degrader with antitumor activity.Palazestrant inhibits 17b-estradiol (E2), inhibits MCF7 and CAMA-1 cell proliferation, and can be used in breast cancer research. Target: Estrogen/progestogen...
| Schlagworte: | OP1250, OP 1250, OP-1250 |
| Anwendung: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2092925-89-6 |
| MW: | 449.6 D |
ab 286,00 €
Glycitein
Artikelnummer: TGM-T6S0325-1mL
Description: 1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Target: Apoptosis, Others. Smiles: COc1cc2c(cc1O)occ(-c1ccc(O)cc1)c2=O. References: Pan W , Ikeda K , Takebe M , et al. Genistein, daidzein and...
| Schlagworte: | Glycetein |
| Anwendung: | Metabolic studies |
| CAS | 40957-83-3 |
| MW: | 284.26 D |
ab 50,00 €
10-Chloroestra-1,4-diene-3,17-dione
Artikelnummer: TGM-T83907-10mg
Description: 10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor alpha (ERalpha) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aromatase inhibitor, exhibiting an IC50 of 2.4 µM. Target: Others. Smiles:...
| Schlagworte: | 10-chloro-1,4-Estradiene |
| Anwendung: | Sterone ERalpha agonist |
| CAS | 91413-55-7 |
| MW: | 304.8 D |
ab 74,00 €
BE-26263
Artikelnummer: TGM-T85037-10mg
Description: BE-26263, an antiosteoporotic agent isolated from Scedosporium apiospermum, exhibits an estrogenic effect [1]. Target: Others. Smiles: OC1=C2C(=CC(O)=C1)CC(C)OC(=O)CC(C)OC(=O)CC(C)OC(=O)C=3C(CC(C)OC(=O)CC(C)OC2=O)=CC(O)=CC3O
| Anwendung: | Fungal metabolite |
| CAS | 147716-81-2 |
| MW: | 646.64 D |
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WAY-169916
Artikelnummer: TGM-T8981-100mg
Description: WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER), inhibiting NF-kB transcriptional activity while being devoid of conventional estrogenic activity. Target: NF-kappaB. Smiles: C(F)(F)(F)C1=C2C(C(=NN2CC=C)C3=C(O)C=C(O)C=C3)=CC=C1. References: Liu Z, Wang L, Tan H, Zhou S, Fu T, Xia Y,...
| Schlagworte: | WAY 169916, WAY169916 |
| Anwendung: | Pathway-selective estrogen receptor ligand |
| CAS | 669764-18-5 |
| MW: | 334.29 D |
ab 41,00 €