Zu "K08550" wurden 367 Artikel gefunden!
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Tamoxifen
Artikelnummer: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 78,00 €
LSZ-102
Artikelnummer: Cay41834-1
LSZ-102 is an estrogen receptor alpha (ERalpha) degrader (IC50 = 0.2 nM). It reduces 17beta-estradiol-induced transcription in a reporter assay using MCF-7 breast cancer cells expressing ERalpha (IC50 = 6 nM). LSZ-102 decreases the proliferation of MCF-7 cells (IC50 = 1.7 nM). In vivo, LSZ-102 (20 mg/kg per day)...
| Schlagworte: | 3-[4-[[2E-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid |
| Anwendung: | ERalpha degrader |
| CAS | 2135600-76-7 |
| MW: | 470.5 D |
ab 62,00 €
Raloxifene
Artikelnummer: Cay41845-1
Raloxifene (Cay-41845) is an analytical reference standard categorized as a selective estrogen receptor modulator (SERM). It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for analytical forensic applications. This product is also available as a general...
| Schlagworte: | Keoxifene, LY156758, NSC 747974,... |
| Anwendung: | Analytical reference standard, selective estrogen receptor modulator (SERM) |
| CAS | 84449-90-1 |
| MW: | 473.6 D |
ab 150,00 €
Tamoxifen (citrate)
Artikelnummer: Cay11629-10
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide,... |
| Anwendung: | Estrogen receptor (ER) modulator, Apoptosis inducer |
| CAS | 54965-24-1 |
| MW: | 563.6 D |
ab 60,00 €
17-Epiestriol
Artikelnummer: TGM-T36913-5mg
Description: 17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16alpha-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor alpha (ERalpha) and ERbeta with relative binding affinities of 29 and 80 compared with 17beta-estradiol .2. Target:...
| Anwendung: | Estrone metabolite |
| CAS | 1228-72-4 |
| MW: | 288.38 D |
1.300,00 €
ARV-471
Artikelnummer: TGM-T39710-10mg
Description: ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. Target: Estrogen Receptor/ERR, PROTACs. Smiles:...
| Schlagworte: | Vepdegestrant |
| Anwendung: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2229711-68-4 |
| MW: | 723.9 D |
ab 264,00 €
AZD9496
Artikelnummer: TGM-T3975-100mg
Description: AZD9496 is an orally available selective estrogen receptor(ERalpha) antagonist, with potential antineoplastic activity. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: C(C(C)(C)F)N1[C@@H](C2=C(C=3C(N2)=CC=CC3)C[C@H]1C)C4=C(F)C=C(/C=C/C(O)=O)C=C4F. References: Weir HM, et al....
| Anwendung: | Estrogen receptor downregulator & antagonist |
| CAS | 1639042-08-2 |
| MW: | 442.47 D |
ab 52,00 €
Tibolone
Artikelnummer: TGM-T4549-1mL
Description: Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis. Target: Estrogen/progestogen Receptor. Smiles:...
| Schlagworte: | tibolona, tibolonum |
| Anwendung: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 5630-53-5 |
| MW: | 312.45 D |
ab 42,00 €
Lasofoxifene
Artikelnummer: TGM-T62119-10mg
Description: Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic. Target: Others. Smiles: OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1
| Anwendung: | SERM |
| CAS | 180916-16-9 |
| MW: | 413.55 D |
ab 295,00 €
H3B-5942
Artikelnummer: TGM-T5633-100mg
Description: H3B-5942 belongs to a class of ERalpha antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CC\C(=C(\c1ccc(OCCNC\C=C\C(=O)N(C)C)cc1)c1ccc2[nH]ncc2c1)c1ccccc1. References: Discovery of Selective...
| Anwendung: | Selective estrogen receptor covalent antagonist (SERCA) |
| CAS | 2052128-15-9 |
| MW: | 494.63 D |
ab 46,00 €
Palazestrant
Artikelnummer: TGM-T72945-10mg
Description: Palazestrant (OP-1250) is an orally available and highly potent estrogen receptor antagonist and selective ER degrader with antitumor activity.Palazestrant inhibits 17b-estradiol (E2), inhibits MCF7 and CAMA-1 cell proliferation, and can be used in breast cancer research. Target: Estrogen/progestogen...
| Schlagworte: | OP1250, OP 1250, OP-1250 |
| Anwendung: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2092925-89-6 |
| MW: | 449.6 D |
ab 292,00 €
Glycitein
Artikelnummer: TGM-T6S0325-1mL
Description: 1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Target: Apoptosis, Others. Smiles: COc1cc2c(cc1O)occ(-c1ccc(O)cc1)c2=O. References: Pan W , Ikeda K , Takebe M , et al. Genistein, daidzein and...
| Schlagworte: | Glycetein |
| Anwendung: | Metabolic studies |
| CAS | 40957-83-3 |
| MW: | 284.26 D |
ab 49,00 €