Zu "K08540" wurden 49 Artikel gefunden!
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Desmethyl Bosentan
Artikelnummer: TGM-T37351-1mg
Description: Desmethyl bosentan, an active metabolite of the endothelin receptor antagonist bosentan, activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 µM. Target: Others. Smiles:...
| Anwendung: | Bosentan active metabolite |
| CAS | 253688-61-8 |
| MW: | 537.59 D |
ab 289,00 €
Specific PXR antagonist 70
Artikelnummer: TGM-T41255-100mg
Description: Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells. Target: Others. Smiles: COC1=CC=C(OC)C(=C1)N1N=NC(=C1C)S(=O)(=O)C1=CC=C(C=C1)C(C)(C)C. References: Chai SC, Lin W, Li Y,...
| Anwendung: | PXR antagonist |
| CAS | 931314-31-7 |
| MW: | 415.51 D |
ab 48,00 €
beta-Acids colupulone
Artikelnummer: TGM-T80696-1mg
Description: Colupulone, a bitter beta-acid, can be isolated from hops [1]. Smiles: O=C(C=1C(O)=C(C(=O)C(C1O)(CC=C(C)C)CC=C(C)C)CC=C(C)C)C(C)C
| Anwendung: | Bioactive hop beta-acid |
| CAS | 468-27-9 |
| MW: | 400.55 D |
ab 330,00 €
NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
Artikelnummer: TGM-TMPH-01793-100ug
Description: NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
| Schlagworte: | Pregnane X receptor, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| MW: | 69.8 kD |
ab 193,00 €
12-Ketodeoxycholic acid
Artikelnummer: TGM-T14002-100mg
Description: 12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1]. Target: Endogenous Metabolite. Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@H](O)CC[C@]4(C)[C@H]3CC(=O)[C@]12C. References: Chen H, et al. Metabolomics insights into activated redox...
| Anwendung: | DCA metabolite, human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.56 D |
ab 56,00 €
Nuclear receptor subfamily 1 group I member 2 (NR1I2),...
Artikelnummer: CSB-EP016048HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-434aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Target Protein Sequence: MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE...
| Schlagworte: | PXR, SXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 69.8 kD |
ab 213,00 €
Anti-NR1I2 / PXR
Artikelnummer: NSJ-RQ5593
0.5mg/ml if reconstituted with 0.2ml sterile DI water. In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear...
| Schlagworte: | Anti-PXR, Anti-SXR, Anti-NR1I2, Anti-Pregnane X receptor, Anti-Orphan nuclear receptor PXR, Anti-Orphan nuclear receptor... |
| Anwendung: | WB, IHC (paraffin), FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Rat PXR (Pregnane X Receptor) ELISA Kit
Artikelnummer: ELK-ELK6436.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PXR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PXR. Next, Avidin...
| Schlagworte: | Pxr, Nr1i2, Pregnane X receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Human PXR (Pregnane X Receptor) ELISA Kit
Artikelnummer: ELK-ELK3247.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PXR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PXR. Next,...
| Schlagworte: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
12-keto Lithocholic Acid
Artikelnummer: Cay29547-5
12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA, Cay-20756, Cay-18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Cay-20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol...
| Schlagworte: | 12-keto-LCA, 12-Oxolithocholic Acid, (3alpha,5beta)-3-hydroxy-12-oxo-cholan-24-oic acid |
| Anwendung: | DCA metabolite, Human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.6 D |
ab 105,00 €
Pregnenolone Carbonitrile
Artikelnummer: Cay16343-25
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...
| Schlagworte: | PCN, Pregnenolone 16alpha-carbonitrile, SC-4674, 3beta-hydroxy-20-oxo-pregn-5-ene-16alpha-carbonitrile |
| Anwendung: | Rodent pregnane X receptor (PXR) agonist |
| CAS | 1434-54-4 |
| MW: | 341.5 D |
ab 54,00 €
PXR (human) Reporter Assay Kit
Artikelnummer: IB-IB07001-32
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Schlagworte: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €