Zu "K08537" wurden 73 Artikel gefunden!
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HPG1860
Artikelnummer: Cay39481-1
HPG1860 is a farnesoid X receptor (FXR) agonist. It induces luminescence in a reporter assay using HEK293T cells expressing human FXR (EC50 = 18 nM). In vivo, HPG1860 (1, 3, or 10 mg/kg per day) decreases the serum levels of alanine transaminase (ALT) and total cholesterol, as well as hepatic inflammation, fat...
| Schlagworte: | 2-[(2R)-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methyl]-2-methyl-1-piperazinyl]-4-methoxy-6-benzothiazolecar... |
| Anwendung: | FXR agonist |
| CAS | 2226133-29-3 |
| MW: | 573.5 D |
ab 35,00 €
(Z)-Guggulsterone
Artikelnummer: TGM-T17280-100mg
Description: (Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis. Target: Apoptosis, Akt, VEGFR. Smiles: C\C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C. References: Xiao...
| Anwendung: | FXR antagonist |
| CAS | 39025-23-5 |
| MW: | 312.45 D |
ab 89,00 €
LY2562175
Artikelnummer: TGM-T15806-100mg
Description: LY2562175 is an effective and selective FXR agonist (EC50: 193 nM). Target: FXR, Autophagy. Smiles: Cn1cc(C(O)=O)c2ccc(cc12)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1. References: Genin MJ, et al. Discovery of...
| Anwendung: | Bile acid receptor (FXR) agonist |
| CAS | 1103500-20-4 |
| MW: | 540.44 D |
ab 159,00 €
Stigmasterol
Artikelnummer: TGM-T2967-100mg
Description: Stigmasterol (Stigmasterin) is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk. Stigmasterol has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy...
| Schlagworte: | Stigmasterin, beta-Stigmasterol |
| Anwendung: | Chemopreventive compound |
| CAS | 83-48-7 |
| MW: | 412.69 D |
54,00 €
DY268
Artikelnummer: TGM-T31587-100mg
Description: DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM). Target: FXR. Smiles: C(NC1=CC(S(=O)(=O)N2CCOCC2)=C(C)C=C1)(=O)C=3C(=NN(CC4=CC(OC)=CC=C4)C3)C5=CC=C(C)C=C5. References: Roman-Lopez J,...
| Schlagworte: | DY-268, DY 268 |
| Anwendung: | Farnesoid X receptor (FXR) antagonist |
| CAS | 1609564-75-1 |
| MW: | 560.66 D |
ab 34,00 €
(E)-Guggulsterone
Artikelnummer: TGM-T36563-1mL
Description: Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as...
| Anwendung: | FXR antagonist |
| CAS | 39025-24-6 |
| MW: | 312.45 D |
ab 58,00 €
CAY10771
Artikelnummer: TGM-T37414-10mg
Description: CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor delta (PPARdelta).1It activates FXR and PPARdelta in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor alpha...
| Anwendung: | FXR / PPARdelta dual agonist |
| CAS | 2522599-79-5 |
| MW: | 559.87 D |
ab 237,00 €
Tauro-alpha-muricholic Acid (sodium salt)
Artikelnummer: TGM-T37416-1mg
Description: Tauro-alpha-muricholic acid (TalphaMCA) is an antagonist of the farnesoid X receptor (FXR, IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid alpha-muricholic acid . TalphaMCA is common in rodents but has also been found in small amounts in human serum. Target: Others....
| Anwendung: | Farnesoid X receptor (FXR) antagonist |
| CAS | 2260905-08-4 |
| MW: | 538.7 D |
386,00 €
Tropifexor
Artikelnummer: TGM-T4379-100mg
Description: Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. Target: Autophagy, FXR. Smiles: OC(=O)c1cc(F)c2nc(sc2c1)N1[C@H]2CC[C@@H]1C[C@@H](C2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1. References: Tully DC,etal.Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR...
| Schlagworte: | LJN452 |
| Anwendung: | Targets farnesoid X receptor (NR1H4, FXR) |
| CAS | 1383816-29-2 |
| MW: | 603.58 D |
ab 87,00 €
Cilofexor
Artikelnummer: TGM-T7436-100mg
Description: Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. Target: Autophagy, FXR. Smiles: OC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
| Anwendung: | Farnesoid X receptor (FXR) agonist |
| CAS | 1418274-28-8 |
| MW: | 586.85 D |
ab 46,00 €
Nidufexor
Artikelnummer: TGM-T7886-100mg
Description: Nidufexor is an agonist for the farnesoid X receptor (FXR). Target: FXR, Autophagy. Smiles: Cn1nc(C(=O)N(Cc2ccccc2)Cc2ccc(cc2)C(O)=O)c2COc3ccc(Cl)cc3-c12. References: Chianelli D, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr...
| Anwendung: | FXR partial agonist |
| CAS | 1773489-72-7 |
| MW: | 487.93 D |
ab 51,00 €
Tauro-Obeticholic Acid sodium
Artikelnummer: TGM-T83858-1mg
Description: Tauro-obeticholic acid, a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid, is an active metabolite of obeticholic acid. This compound undergoes taurine conjugation in the liver to form from obeticholic acid and can be reconverted to its original form by...
| Schlagworte: | T-ECDCA, Tauro-OCA, Tauro-6-Ethylchenodeoxycholic Acid, Obeticholic Acid Taurine Conjugate, Tauro-6-Ethyl-CDCA |
| Anwendung: | Obeticholic acid active metabolite, choleretic |
| CAS | 2278141-79-8 |
| MW: | 549.74 D |
ab 388,00 €