Zu "K08536" wurden 66 Artikel gefunden!
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LXR-alpha Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01819-100ug
Description: LXR-alpha Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q13133.
| Schlagworte: | Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3 |
| MW: | 53.1 kD |
ab 198,00 €
LXR-623
Artikelnummer: TGM-T1783-100mg
Description: LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. Target: Liver X Receptor. Smiles: Fc1ccc(cc1)-c1n(Cc2ccc(F)cc2Cl)nc2c(cccc12)C(F)(F)F. References: Katz A, et al. J Clin Pharmacol. 2009, 49(6):643-9.
| Schlagworte: | WAY 252623, LXR623 |
| Anwendung: | LXR agonist |
| CAS | 875787-07-8 |
| MW: | 422.78 D |
ab 46,00 €
T0901317
Artikelnummer: TGM-T6690-100mg
Description: T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 µM, respectively, it inhibits nuclear factor/kappaB (NF/kappaB). Target: Apoptosis, FXR, ROR, Liver X Receptor. Smiles: C(C(F)(F)F)(C(F)(F)F)(O)C1=CC=C(N(S(=O)(=O)C2=CC=CC=C2)CC(F)(F)F)C=C1. References: Repa...
| Anwendung: | Potent, cell permeable, selective LXRalpha / LXRbeta agonist |
| CAS | 293754-55-9 |
| MW: | 481.33 D |
ab 33,00 €
SR9238
Artikelnummer: TGM-T16930-10mg
Description: SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRalpha and LXRbeta, respectively). Target: Liver X Receptor. Smiles: CCOC(=O)c1ccc(CN(Cc2ccc(cc2)-c2cccc(c2)S(C)(=O)=O)S(=O)(=O)c2c(C)cc(C)cc2C)o1. References: Griffett K, et al. A liver-selective LXR inverse...
| Anwendung: | LXRA / LXRB inverse agonist |
| CAS | 1416153-62-2 |
| MW: | 595.73 D |
ab 42,00 €
GSK2033
Artikelnummer: TGM-T15427-100mg
Description: GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRalpha or LXRbeta, respectively). Target: Liver X Receptor. Smiles: Cc1cc(C)c(c(C)c1)S(=O)(=O)N(Cc1ccc(o1)C(F)(F)F)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O. References: Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor...
| Anwendung: | LXRalpha / LXRbeta antagonist |
| CAS | 1221277-90-2 |
| MW: | 591.66 D |
ab 45,00 €
GSK3987
Artikelnummer: TGM-T27478-100mg
Description: GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. Target: Liver X Receptor. Smiles: COc1ccc(NC2=C(C(=O)N(Cc3ccccc3)C2=O)c2ccccc2)cc1. References: Ranganathan PV, et al. Netrin-1-treated macrophages protect the kidney against...
| Anwendung: | LXRalpha / LXRbeta dual agonist |
| CAS | 264206-85-1 |
| MW: | 384.43 D |
ab 97,00 €
GW3965 hydrochloride
Artikelnummer: TGM-T6310-100mg
Description: GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRalpha/beta (EC50: 190/30 nM). Target: Liver X Receptor. Smiles: c1ccc(cc1)C(CN(CCCOc1cccc(c1)CC(=O)O)Cc1c(c(ccc1)C(F)(F)F)Cl)c1ccccc1.Cl. References: Collins JL, et al. J Med Chem. 2002, 45(10), 1963-1966.
| Schlagworte: | GW3965 HCl |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 405911-17-3 |
| MW: | 618.51 D |
ab 37,00 €
Anti-NR1H3
Artikelnummer: CSB-PA004906.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-LXRA, Anti-NR1H3, Anti-Liver X receptor alpha, Anti-Oxysterols receptor LXR-alpha, Anti-Nuclear receptor subfamily 1... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
126,00 €
Oxysterols receptor LXR-alpha (NR1H3), human, recombinant
Artikelnummer: CSB-EP619753HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-402aa. Protein Length: Full Length of Isoform 3. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MPHSAGGTAG VGLEAAEPTA LLTRAEPPSE PTEIRPQKRK KGPAPKMLGN ELCSVCGDKA SGFHYNVLSC EGCKGFFRRS VIKGAHYICH SGGHCPMDTY MRRKCQECRL RKCRQAGMRE...
| Schlagworte: | LXRA, NR1H3, Liver X receptor alpha, Oxysterols receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 61.7 kD |
ab 219,00 €
Oxysterols receptor LXR-alpha (NR1H3), human, recombinant
Artikelnummer: CSB-EP619753HUb1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-402aa. Protein Length: Full Length of Isoform 3. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MPHSAGGTAG VGLEAAEPTA LLTRAEPPSE PTEIRPQKRK KGPAPKMLGN ELCSVCGDKA SGFHYNVLSC EGCKGFFRRS VIKGAHYICH SGGHCPMDTY...
| Schlagworte: | LXRA, NR1H3, Liver X receptor alpha, Oxysterols receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 53.1 kD |
ab 219,00 €
GW 3965 (hydrochloride)
Artikelnummer: Cay10054-1
The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
| Schlagworte: | 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 405911-17-3 |
| MW: | 618.5 D |
ab 35,00 €
25(S)-27-hydroxy Cholesterol
Artikelnummer: Cay14791-1
The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 56845-83-1 |
| MW: | 402.7 D |
ab 78,00 €