Zu "K08535" wurden 61 Artikel gefunden!
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27-Hydroxycholesterol
Artikelnummer: TGM-TQ0274-1mg
Description: 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. Target: Estrogen/progestogen Receptor, Liver X Receptor. Smiles: [H][C@@]12CC[C@H]([C@H](C)CCC[C@@H](C)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C....
| Schlagworte: | 25(R)-27-hydroxy Cholesterol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 20380-11-4 |
| MW: | 402.65 D |
ab 46,00 €
Dendrogenin A
Artikelnummer: TGM-T83765-10mg
Description: Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6alpha-epoxy cholesterol through histamine conjugation via DDA synthase. This compound is present in...
| Schlagworte: | DDA |
| Anwendung: | Selective liver X receptor (LXR) modulator (SLiM), ChEH inhibitor |
| CAS | 1191043-85-2 |
| MW: | 513.8 D |
ab 77,00 €
SR9243
Artikelnummer: TGM-T1801-100mg
Description: SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction, shows anticancer activity and selectively targets the lipogenesis and Warburg effect. Target: Liver X Receptor. Smiles: Cc1cc(C)c(c(C)c1)S(=O)(=O)N(CCc1cccc(Br)c1)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O. References: Flaveny CA, et al....
| Anwendung: | Cell-permeable LXR inverse agonist |
| CAS | 1613028-81-1 |
| MW: | 626.62 D |
ab 33,00 €
SR 1903
Artikelnummer: TGM-T35638-10mg
Description: SR 1903 is a modulator of retinoic acid receptor-related orphan receptor gamma (RORgamma) and liver X receptor (LXR).1 It is an inverse agonist of RORgamma (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor gamma (PPARgamma,...
| Anwendung: | RORgamma / LXR modulator |
| CAS | 1414248-06-8 |
| MW: | 523.51 D |
ab 93,00 €
BMS-779788
Artikelnummer: TGM-T3970-100mg
Description: BMS-779788 (XL-652) is an LXRalpha/beta partial agonist (IC50: 68/14 nM). Target: Liver X Receptor. Smiles: CC(C)(O)c1cn(c(n1)C(C)(C)c1ccccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O. References: Kick, E., Martin, R., Xie, Y., Flatt, B., Schweiger, E., & Wang, T. et al. (2015). Liver X Receptor (LXR) partial...
| Schlagworte: | XL-652, BMS-788, XL652, XL 652, EXEL04286652 |
| Anwendung: | LXR alpha & beta partial agonist |
| CAS | 918348-67-1 |
| MW: | 509.06 D |
ab 33,00 €
AZ876
Artikelnummer: TGM-T5178-100mg
Description: AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRalpha and hLXRbeta respectively. Target: Liver X Receptor. Smiles: CC(C)(C)N1C(=O)C(Nc2ccc(cc2)N2CCCCC2)=C(c2ccccc2)S1(=O)=O. References: van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876,...
| Anwendung: | LXR agonist |
| CAS | 898800-26-5 |
| MW: | 439.57 D |
ab 45,00 €
24(S),25-Epoxycholesterol
Artikelnummer: TGM-T71756-1mg
Description: 24(S),25-Epoxycholesterol is an oxysterol agonist of the liver X receptor. Target: Others. Smiles: CC(CCC1OC1(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
| Anwendung: | Oxysterol, LXR activator |
| CAS | 77058-74-3 |
| MW: | 400.64 D |
492,00 €
RGX-104
Artikelnummer: TGM-T7768-100mg
Description: RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR). Target: Liver X Receptor. Smiles: C[C@H](CCOc1cccc(CC(O)=O)c1)N(CC(c1ccccc1)c1ccccc1)Cc1cccc(c1Cl)C(F)(F)F. References: Tavazoie M F , Pollack I , Tanqueco R , et al. LXR/ApoE Activation Restricts...
| Schlagworte: | RGX-104 free Acid |
| Anwendung: | Targets liver X receptor beta (NR1H2, LXRB) |
| CAS | 610318-54-2 |
| MW: | 596.08 D |
ab 34,00 €
T0901317
Artikelnummer: Cay71810-10
The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
| Schlagworte: | N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
| Anwendung: | LXRalpha agonist, LXRbeta agonist |
| CAS | 293754-55-9 |
| MW: | 481.3 D |
ab 55,00 €
Oxysterols receptor LXR-beta (NR1H2), partial, human,...
Artikelnummer: CSB-EP016045HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 212-460aa. Protein Length: Partial. Tag Info: Tag-Free. Target Protein Sequence: GEGEGVQLTA AQELMIQQLV AAQLQCNKRS FSDQPKVTPW PLGADPQSRD ARQQRFAHFT ELAIISVQEI VDFAKQVPGF LQLGREDQIA LLKASTIEIM LLETARRYNH ETECITFLKD FTYSKDDFHR AGLQVEFINP IFEFSRAMRR...
| Schlagworte: | LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 28.7 kD |
ab 439,00 €
Oxysterols receptor LXR-beta (NR1H2), partial, human,...
Artikelnummer: CSB-EP016045HU1a0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 212-460aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GEGEGVQLTA AQELMIQQLV AAQLQCNKRS FSDQPKVTPW PLGADPQSRD ARQQRFAHFT ELAIISVQEI VDFAKQVPGF LQLGREDQIA LLKASTIEIM LLETARRYNH ETECITFLKD FTYSKDDFHR AGLQVEFINP...
| Schlagworte: | LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 32.7 kD |
ab 292,00 €
25(R)-27-hydroxy Cholesterol
Artikelnummer: Cay14790-1
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 20380-11-4 |
| MW: | 402.7 D |
ab 78,00 €