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Zu "K08528" wurden 53 Artikel gefunden!
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Artikelnummer: Cay11017-50
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...
Schlagworte: | atRA, NSC 122578, NSC 122758, RA, Vitamin A Acid,... |
Anwendung: | RAR / RXR ligand |
CAS | 302-79-4 |
MW: | 300.4 D |
ab 48,00 €
Artikelnummer: ELK-ELK4436.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RARb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RARb. Next,...
Schlagworte: | HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay20853-10
Acitretin is a retinoid and an active metabolite of the retinoid etretinate (Cay-19878) that has antiproliferative activities. It binds to cellular retinoic acid binding protein I (CRABP-I) and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant...
Schlagworte: | all-trans Acitretin, Ro 10-1670, Ro 10-1670/000,... |
Anwendung: | Etretinate metabolite, Antiproliferative agent, RAR agonist |
CAS | 55079-83-9 |
MW: | 326.4 D |
ab 43,00 €
Artikelnummer: Cay25415-500
all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid (Cay-11017) by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and...
Schlagworte: | atRA-d5, RA-d5, Vitamin A Acid-d5,... |
Anwendung: | RAR / RXR ligand, protein synthesis inhibitor, GC-MS, LC-MS, internal standard |
MW: | 305.5 D |
ab 287,00 €
Artikelnummer: IB-IB02101
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
Schlagworte: | HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B... |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | human |
ab 1.448,00 €
Artikelnummer: LKT-R1877.25
All-trans retinol is a diterpenoid component of vitamin A. This compound is an essential vitamin and is necessary for effective vision, skin health, and bone growth. Retinol and its metabolites bind retinoic acid receptors (RARs) and retinoid X receptors (RXRs), both of which have multiple isotypes and isoforms....
Schlagworte: | Alphasterol, Retinol, Avitol, Vitamin A |
Anwendung: | Retinoic acid receptor (RAR) agonist |
CAS | 68-26-8 |
MW: | 286.45 D |
ab 113,00 €
Artikelnummer: Cay16031-1
CD2665 is a selective retinoic acid receptor (RAR)beta and RARgamma antagonist (Kds = 110, 306, and > 2,250 nM for RARgamma, RARbeta, and RARalpha, respectively, with no binding at RXRalpha). At 10-7 M, it has been used to abrogate retinoic acid (Cay-11017)-induced antiproliferative and antidifferentiative effects...
Schlagworte: | 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-benzoic acid |
Anwendung: | RAR beta / gamma antagonist |
CAS | 170355-78-9 |
MW: | 486.6 D |
ab 50,00 €
Artikelnummer: BPS-60603
The RAR beta Reporter (Luc)-HEK293 cell line is designed for monitoring the activity of RARbeta. The RAR beta Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARbeta (accession...
Schlagworte: | RAR beta, Retinoic acid receptor beta, RARB, |
Anwendung: | RARbeta reporter assays |
2.719,00 €
Artikelnummer: Cay16144-10
TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR...
Schlagworte: | AGN 191183, Arotinoid Acid, Ro 13-7410,... |
Anwendung: | Retinoic acid receptor agonist |
CAS | 71441-28-6 |
MW: | 348.5 D |
ab 60,00 €
Artikelnummer: Cay19076-5
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARbeta and an antagonist of RARalpha and RARgamma. It has been shown to inhibit the proliferation of normal breast cells via the...
Schlagworte: | BMS 189453, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid |
Anwendung: | RARbeta agonist, RARalpha / RARgamma antagonist |
CAS | 166977-43-1 |
MW: | 380.5 D |
ab 50,00 €
Artikelnummer: Cay22124-500
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR, EC50s = 77, 35, and 4 nM for RARalpha, RARbeta, and RARgamma, respectively). 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of...
Schlagworte: | 5,6-epoxy RA, 5,6-epoxy-atRA, 5,6-epoxy-5,6-dihydro-retinoic acid |
Anwendung: | RAR agonist |
CAS | 13100-69-1 |
MW: | 316.4 D |
ab 246,00 €
Artikelnummer: Cay23975-500
AGN 193109 is a potent antagonist of retinoic acid receptors (RARs, Kd = 2, 2, and 3 nM for RARalpha, beta, and gamma, respectively). It is selective for RARs over retinoid X receptors (RXRs, Kd = >10,000 nM for human RXRalpha, beta, and gamma receptors). AGN 193109 reverses changes in cell morphology induced by the...
Schlagworte: | CD3106, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoic acid, monosodium salt |
Anwendung: | Retinoic acid receptor antagonist |
CAS | 2319838-82-7 |
MW: | 414.5 D |
ab 163,00 €